Therapeutic targeting of tumor–stroma interactions

The PI3K/Akt pathway upregulates Id1 and integrin α4 to enhance recruitment of human ovarian cancer endothelial progenitor cells

(2010) Yajuan Su et al.   BMC CANCER

Inhibition of focal adhesion kinase suppresses the adverse phenotype of endocrine-resistant breast cancer cells and improves endocrine response in endocrine-sensitive cells

(2010) Stephen Hiscox et al.   BREAST CANCER RESEARCH AND TREATMENT

A randomized phase 2 study of etaracizumab, a monoclonal antibody against integrin αvβ3, ± dacarbazine in patients with stage IV metastatic melanoma

(2010) Peter Hersey et al.   CANCER

Hypoxia, inflammation, and the tumor microenvironment in metastatic disease

(2010) Elizabeth C. Finger et al.   CANCER AND METASTASIS REVIEWS

3D collagen type I matrix inhibits the antimigratory effect of doxorubicin

(2010) Emilie Millerot-Serrurot et al.   Cancer Cell International

Survivin Enhances Motility of Melanoma Cells by Supporting Akt Activation and  5 Integrin Upregulation

(2010) J. A. McKenzie et al.   CANCER RESEARCH

Macrophage Expression of Hypoxia-Inducible Factor-1  Suppresses T-Cell Function and Promotes Tumor Progression

(2010) A. L. Doedens et al.   CANCER RESEARCH

Breast Cancer Cells in Three-dimensional Culture Display an Enhanced Radioresponse after Coordinate Targeting of Integrin  5 1 and Fibronectin

(2010) J.-M. Nam et al.   CANCER RESEARCH

Cancer Exosomes Trigger Fibroblast to Myofibroblast Differentiation

(2010) J. Webber et al.   CANCER RESEARCH

Significance of integrin αvβ5 and erbB3 in enhanced cell migration and liver metastasis of colon carcinomas stimulated by hepatocyte-derived heregulin

(2010) Toshiaki Yoshioka et al.   CANCER SCIENCE

Dietary and Genetic Obesity Promote Liver Inflammation and Tumorigenesis by Enhancing IL-6 and TNF Expression

(2010) Eek Joong Park et al.   CELL

Mechanisms by which inflammation may increase intestinal cancer risk in inflammatory bowel disease

(2010) Pamela M. OʼConnor et al.   INFLAMMATORY BOWEL DISEASES

Phase I/IIa Study of Cilengitide and Temozolomide With Concomitant Radiotherapy Followed by Cilengitide and Temozolomide Maintenance Therapy in Patients With Newly Diagnosed Glioblastoma

(2010) Roger Stupp et al.   JOURNAL OF CLINICAL ONCOLOGY

In Aged Mice, Outgrowth of Intraocular Melanoma Depends on Proangiogenic M2-Type Macrophages

(2010) L. V. Ly et al.   JOURNAL OF IMMUNOLOGY

Pharmacodynamic (Phase 0) Study Using Etaracizumab in Advanced Melanoma

(2010) Stergios J. Moschos et al.   JOURNAL OF IMMUNOTHERAPY

Integrins as Target: First Phase III Trial Launches, but Questions Remain

(2010) Andrea Carter   JNCI-Journal of the National Cancer Institute

Imatinib Upregulates Compensatory Integrin Signaling in a Mouse Model of Gastrointestinal Stromal Tumor and Is More Effective When Combined with Dasatinib

(2010) F. Rossi et al.   MOLECULAR CANCER RESEARCH

Culture of human breast cancer cell line (MDA-MB-231) on fibronectin-coated surface induces pro-matrix metalloproteinase-9 expression and activity

(2010) Gargi Maity et al.   TUMOR BIOLOGY

High-Density Gene Expression Analysis of Tumor-Associated Macrophages from Mouse Mammary Tumors

(2009) Laureen S. Ojalvo et al.   AMERICAN JOURNAL OF PATHOLOGY

β 3 -Integrin Expression on Tumor Cells Inhibits Tumor Progression, Reduces Metastasis, and Is Associated with a Favorable Prognosis in Patients with Ovarian Cancer

(2009) Swayamjot Kaur et al.   AMERICAN JOURNAL OF PATHOLOGY

External validation suggests Integrin beta 3 as prognostic biomarker in serous ovarian adenocarcinomas

(2009) Karolina Partheen et al.   BMC CANCER

E-cadherin, β-catenin, and ZEB1 in malignant progression of cancer

(2009) Otto Schmalhofer et al.   CANCER AND METASTASIS REVIEWS

Targeting Focal Adhesion Kinase with Dominant-Negative FRNK or Hsp90 Inhibitor 17-DMAG Suppresses Tumor Growth and Metastasis of SiHa Cervical Xenografts

(2009) J. Schwock et al.   CANCER RESEARCH

Rapamycin inhibits lung metastasis of B16 melanoma cells through down-regulating alphav integrin expression and up-regulating apoptosis signaling

(2009) Zhuoshun Yang et al.   CANCER SCIENCE

β1 integrin targeting to enhance radiation therapy

(2009) Jin-Min Nam et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Oscillatory Flow-induced Proliferation of Osteoblast-like Cells Is Mediated by αvβ3and β1Integrins through Synergistic Interactions of Focal Adhesion Kinase and Shc with Phosphatidylinositol 3-Kinase and the Akt/mTOR/p70S6K Pathway

(2009) Ding-Yu Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Src with AZD0530 Reveals the Src-Focal Adhesion Kinase Complex as a Novel Therapeutic Target in Papillary and Anaplastic Thyroid Cancer

(2009) Rebecca E. Schweppe et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Serum Vascular Endothelial Growth Factor and Fibronectin Predict Clinical Response to High-Dose Interleukin-2 Therapy

(2009) Marianna Sabatino et al.   JOURNAL OF CLINICAL ONCOLOGY

Stromal Expression of MMP-13 Is Required for Melanoma Invasion and Metastasis

(2009) Paola Zigrino et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation

(2009) G. Solinas et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Integrin ( 6 4) Signals Through Src to Increase Expression of S100A4, a Metastasis-Promoting Factor: Implications for Cancer Cell Invasion

(2009) T. H. Kim et al.   MOLECULAR CANCER RESEARCH

Preclinical anticancer activity of the potent, oral Src inhibitor AZD0530

(2009) Tim P. Green et al.   Molecular Oncology

An integrin αvβ3–c-Src oncogenic unit promotes anchorage-independence and tumor progression

(2009) Jay S Desgrosellier et al.   NATURE MEDICINE

Hepatic tumor–stroma crosstalk guides epithelial to mesenchymal transition at the tumor edge

(2009) F van Zijl et al.   ONCOGENE

3D cell cultures of human head and neck squamous cell carcinoma cells are radiosensitized by the focal adhesion kinase inhibitor TAE226

(2009) Stephanie Hehlgans et al.   RADIOTHERAPY AND ONCOLOGY

Carcinoma-associated fibroblasts are a rate-limiting determinant for tumour progression

(2009) Masayuki Shimoda et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Stroma–epithelium crosstalk in prostate cancer

(2008) Yi-Nong Niu et al.   ASIAN JOURNAL OF ANDROLOGY

 1 Integrin Inhibition Dramatically Enhances Radiotherapy Efficacy in Human Breast Cancer Xenografts

(2008) C. C. Park et al.   CANCER RESEARCH

Targeting Src Family Kinases Inhibits Growth and Lymph Node Metastases of Prostate Cancer in an Orthotopic Nude Mouse Model

(2008) S. I. Park et al.   CANCER RESEARCH

Inhibition of bone and muscle metastases of lung cancer cells by a decrease in the number of monocytes/macrophages

(2008) Koji Hiraoka et al.   CANCER SCIENCE

Focal Adhesion Kinase: Targeting Adhesion Signaling Pathways for Therapeutic Intervention

(2008) J. T. Parsons et al.   CLINICAL CANCER RESEARCH

Volociximab, a Chimeric Monoclonal Antibody that Specifically Binds  5 1 Integrin: A Phase I, Pharmacokinetic, and Biological Correlative Study

(2008) A. D. Ricart et al.   CLINICAL CANCER RESEARCH

Endothelial???stromal interactions in angiogenesis

(2008) Christopher CW Hughes   CURRENT OPINION IN HEMATOLOGY

The Yin-Yang of tumor-associated macrophages in neoplastic progression and immune surveillance

(2008) Paola Allavena et al.   IMMUNOLOGICAL REVIEWS

Stromal myofibroblasts are drivers of invasive cancer growth

(2008) Olivier De Wever et al.   INTERNATIONAL JOURNAL OF CANCER

“Re-educating” tumor-associated macrophages by targeting NF-κB

(2008) Thorsten Hagemann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Macrophages define the invasive microenvironment in breast cancer

(2008) Jeffrey W. Pollard   JOURNAL OF LEUKOCYTE BIOLOGY

Macrophage polarization in tumour progression

(2008) Antonio Sica et al.   SEMINARS IN CANCER BIOLOGY

Antitumor Activity of Liposomal Prednisolone Phosphate Depends on the Presence of Functional Tumor-Associated Macrophages in Tumor Tissue

(2008) Manuela Banciu et al.   NEOPLASIA