Are we moving in the right direction with osteoarthritis drug discovery?

Unknown

(2016)   ARTHRITIS AND RHEUMATISM

Chondroitin sulphate reduces both cartilage volume loss and bone marrow lesions in knee osteoarthritis patients starting as early as 6 months after initiation of therapy: a randomised, double-blind, placebo-controlled pilot study using MRI

(2011) L. M. Wildi et al.   ANNALS OF THE RHEUMATIC DISEASES

Osteoarthritis year 2010 in review: pathomechanisms

(2011) W.B. van den Berg   OSTEOARTHRITIS AND CARTILAGE

The role of synovial macrophages and macrophage-produced mediators in driving inflammatory and destructive responses in osteoarthritis

(2010) Jan Bondeson et al.   ARTHRITIS AND RHEUMATISM

Activated Synovial Macrophages as Targets for Osteoarthritis Drug Therapy

(2010) Jan Bondeson   CURRENT DRUG TARGETS

Novel Therapies in OA

(2010) Carl R. Flannery   CURRENT DRUG TARGETS

To Seek Shelter from the Wnt in Osteoarthritis? Wnt-Signaling as a Target for Osteoarthritis Therapy

(2010) Arjen B. Blom et al.   CURRENT DRUG TARGETS

Intraarticular Treatments for Osteoarthritis: New Perspectives

(2010) Xavier Chevalier   CURRENT DRUG TARGETS

A Pathway and Approach to Biomarker Validation and Qualification for Osteoarthritis Clinical Trials

(2010) David J. Hunter et al.   CURRENT DRUG TARGETS

Disease Modifying Osteoarthritis Drugs: Facing Development Challenges and Choosing Molecular Targets

(2010) Marie-Pierre Hellio Le Graverand-Gastineau   CURRENT DRUG TARGETS

Advances in the development of novel aggrecanase inhibitors

(2010) Adam M Gilbert et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Pharmacologic therapy for osteoarthritis—the era of disease modification

(2010) David J. Hunter   Nature Reviews Rheumatology

Treatment with TNF-α inhibitor infliximab might reduce hand osteoarthritis in patients with rheumatoid arthritis

(2010) M. Güler-Yüksel et al.   OSTEOARTHRITIS AND CARTILAGE

Varus malalignment negates the structure-modifying benefits of doxycycline in obese women with knee osteoarthritis

(2010) S.A. Mazzuca et al.   OSTEOARTHRITIS AND CARTILAGE

Involvement of the Wnt signaling pathway in experimental and human osteoarthritis: Prominent role of Wnt-induced signaling protein 1

(2009) Arjen B. Blom et al.   ARTHRITIS AND RHEUMATISM

Intraarticular injection of anakinra in osteoarthritis of the knee: A multicenter, randomized, double-blind, placebo-controlled study

(2009) X. Chevalier et al.   ARTHRITIS AND RHEUMATISM

Prevention of cartilage degeneration in a rat model of osteoarthritis by intraarticular treatment with recombinant lubricin

(2009) Carl R. Flannery et al.   ARTHRITIS AND RHEUMATISM

ADAMTS Metalloproteases Generate Active Versican Fragments that Regulate Interdigital Web Regression

(2009) Daniel R. McCulloch et al.   DEVELOPMENTAL CELL

Structural and Inhibition Analysis Reveals the Mechanism of Selectivity of a Series of Aggrecanase Inhibitors

(2009) Micky D. Tortorella et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Periodic knee injections of BMP-7 delay cartilage degeneration induced by excessive running in rats

(2009) Ichiro Sekiya et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

OA clinical trials: current targets and trials for OA. Choosing molecular targets: what have we learned and where we are headed?

(2009) M.-P. Hellio Le Graverand-Gastineau   OSTEOARTHRITIS AND CARTILAGE

Treatment of erosive osteoarthritis of the hands by intra-articular infliximab injections: a pilot study

(2009) Antonella Fioravanti et al.   RHEUMATOLOGY INTERNATIONAL

Protective effects of licofelone, a 5-lipoxygenase and cyclo-oxygenase inhibitor, versus naproxen on cartilage loss in knee osteoarthritis: a first multicentre clinical trial using quantitative MRI

(2008) J-P Raynauld et al.   ANNALS OF THE RHEUMATIC DISEASES

Translating Molecular Insights in Autoimmunity into Effective Therapy

(2008) Marc Feldmann   Annual Review of Immunology

Decreased lubricin concentrations and markers of joint inflammation in the synovial fluid of patients with anterior cruciate ligament injury

(2008) K. A. Elsaid et al.   ARTHRITIS AND RHEUMATISM

The future of the IL-1 receptor antagonist anakinra: from rheumatoid arthritis to adult-onset Still's disease and systemic-onset juvenile idiopathic arthritis

(2008) George D Kalliolias et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

537 INFLIXIMAB (IFX) MIGHT BE PROTECTIVE AGAINST PROGRESSIVE RADIOGRAPHIC INTERPHALANGEAL OSTEOARTHRITIS (OA)

(2008) M. Güler-Yüksel et al.   OSTEOARTHRITIS AND CARTILAGE

The disease modifying osteoarthritis drug (DMOAD): Is it in the horizon?☆

(2008) P QVIST et al.   PHARMACOLOGICAL RESEARCH

Biomarkers in osteoarthritis

(2008) Frances MK Williams et al.   ARTHRITIS RESEARCH & THERAPY

The protective effect of OP-1 on articular cartilage in the development of osteoarthritis

(2007) N. Badlani et al.   OSTEOARTHRITIS AND CARTILAGE

Suppression of early experimental osteoarthritis by in vivo delivery of the adenoviral vector-mediated NF-κBp65-specific siRNA

(2007) L.X. Chen et al.   OSTEOARTHRITIS AND CARTILAGE