Targeting oxidative stress in cancer

Abnormal iron uptake and liver cancer

(2010) Juxing Chen et al.   CANCER BIOLOGY & THERAPY

Antioxidant activities of oleanolic acid in vitro: Possible role of Nrf2 and MAP kinases

(2010) Xin Wang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Hepatitis C virus induces oxidative stress, DNA damage and modulates the DNA repair enzyme NEIL1

(2010) Sampa Pal et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Hydroxytyrosol induces antioxidant/detoxificant enzymes and Nrf2 translocation via extracellular regulated kinases and phosphatidylinositol-3-kinase/protein kinase B pathways in HepG2 cells

(2010) María Angeles Martín et al.   MOLECULAR NUTRITION & FOOD RESEARCH

High levels of oxidative stress in patients with advanced lung cancer

(2010) Hidir ESME et al.   RESPIROLOGY

Global Levels of Histone Modifications Predict Prognosis in Different Cancers

(2009) David B. Seligson et al.   AMERICAN JOURNAL OF PATHOLOGY

Elevated hepatic iron: A confounding factor in chronic hepatitis C

(2009) Harriet C. Isom et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The role of oxidative stress in the biological responses of lung epithelial cells to cigarette smoke

(2009) Stephen P. Faux et al.   BIOMARKERS

Synthesis, cytotoxic and combined cDDP activity of new stable curcumin derivatives

(2009) Erika Ferrari et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Cancer Statistics, 2009

(2009) A. Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Repeated intake of broccoli does not lead to higher plasma levels of sulforaphane in human volunteers

(2009) Natalya Hanlon et al.   CANCER LETTERS

Global Histone Modifications in Breast Cancer Correlate with Tumor Phenotypes, Prognostic Factors, and Patient Outcome

(2009) S. E. Elsheikh et al.   CANCER RESEARCH

Epigenetics in cancer

(2009) S. Sharma et al.   CARCINOGENESIS

Altered Surfactant Protein-A Expression in Type II Pneumocytes in COPD

(2009) Eleni M. Vlachaki et al.   CHEST

Circadian rhythm transcription factor CLOCK regulates the transcriptional activity of the glucocorticoid receptor by acetylating its hinge region lysine cluster: potential physiological implications

(2009) Nancy Nader et al.   FASEB JOURNAL

A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9

(2009) Yuji Nakamaru et al.   FASEB JOURNAL

Prolonged cigarette smoke exposure decreases heme oxygenase-1 and alters Nrf2 and Bach1 expression in human macrophages: Roles of the MAP kinases ERK1/2and JNK

(2009) D. Goven et al.   FEBS LETTERS

Genetic ablation of the Bach1 gene reduces hyperoxic lung injury in mice: Role of IL-6

(2009) Takuya Tanimoto et al.   FREE RADICAL BIOLOGY AND MEDICINE

Patt1, a novel protein acetyltransferase that is highly expressed in liver and downregulated in hepatocellular carcinoma, enhances apoptosis of hepatoma cells

(2009) Zhen Liu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Hemochromatosis: As a conformational disorder

(2009) Steven G. Gray et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

NF-κB regulation: the nuclear response

(2009) Arun K. Mankan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Oxidative stress induced lung cancer and COPD: opportunities for epigenetic therapy

(2009) Matthew W. Lawless et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The epidemiology of hepatocellular cancer: from the perspectives of public health problem to tumor biology

(2009) Stephen Caldwell et al.   JOURNAL OF GASTROENTEROLOGY

Overexpression of metastasis-associated protein 2 is associated with hepatocellular carcinoma size and differentiation

(2009) Hyunseung Lee et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Activation of transcription factor Nrf2 by hepatitis C virus induces the cell-survival pathway

(2009) D. Burdette et al.   JOURNAL OF GENERAL VIROLOGY

Dietary Sulforaphane, a Histone Deacetylase Inhibitor for Cancer Prevention

(2009) Emily Ho et al.   JOURNAL OF NUTRITION

Acetylation of Nrf2 by p300/CBP Augments Promoter-Specific DNA Binding of Nrf2 during the Antioxidant Response

(2009) Z. Sun et al.   MOLECULAR AND CELLULAR BIOLOGY

Effect of Broccoli Intake on Markers Related to Oxidative Stress and Cancer Risk in Healthy Smokers and Nonsmokers

(2009) Patrizia Riso et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Bach1 Modulates Heme Oxygenase-1 Expression in the Neonatal Mouse Lung

(2009) Sacha Kassovska-Bratinova et al.   PEDIATRIC RESEARCH

Global levels of histone modifications predict prostate cancer recurrence

(2009) Jörg Ellinger et al.   PROSTATE

Regulation of Hypoxia-Inducible Factor 2  Signaling by the Stress-Responsive Deacetylase Sirtuin 1

(2009) E. M. Dioum et al.   SCIENCE

Bach1 Deficiency Ameliorates Hepatic Injury in a Mouse Model

(2009) Akio Iida et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Current management strategy of hepatocellular carcinoma

(2009) Bernardino Rampone et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Metabolism-related liabilities of a potent histone deacetylase (HDAC) inhibitor and relevance of the route of administration on its metabolic fate

(2009) M. Fonsi et al.   XENOBIOTICA

Targeting Histone Deacetylases for the Treatment of Immune, Endocrine & Metabolic Disorders

(2009) M. Lawless et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

The Global Histone Modification Pattern Correlates with Cancer Recurrence and Overall Survival in Gastric Adenocarcinoma

(2008) Young Soo Park et al.   ANNALS OF SURGICAL ONCOLOGY

Alcohol alters hepatic FoxO1, p53, and mitochondrial SIRT5 deacetylation function

(2008) Charles S. Lieber et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Effect of chronic alcohol consumption on Hepatic SIRT1 and PGC-1α in rats

(2008) Charles S. Lieber et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hypermethylation of the Keap1 gene in human lung cancer cell lines and lung cancer tissues

(2008) Rui Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Deregulation of histone lysine methyltransferases contributes to oncogenic transformation of human bronchoepithelial cells

(2008) Hideo Watanabe et al.   Cancer Cell International

Multi-targeted prevention of cancer by sulforaphane

(2008) John D. Clarke et al.   CANCER LETTERS

Phase II Trial of Curcumin in Patients with Advanced Pancreatic Cancer

(2008) N. Dhillon et al.   CLINICAL CANCER RESEARCH

Organ-specific requirements for Hdac1 in liver and pancreas formation

(2008) Emily S. Noël et al.   DEVELOPMENTAL BIOLOGY

Histone deacetylase 3 (hdac3) is specifically required for liver development in zebrafish

(2008) Muhammad Farooq et al.   DEVELOPMENTAL BIOLOGY

Liver-specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks

(2008) Sarah K Knutson et al.   EMBO JOURNAL

Multifaceted mechanisms in COPD: inflammation, immunity, and tissue repair and destruction

(2008) K. F. Chung et al.   EUROPEAN RESPIRATORY JOURNAL

Hepatitis C virus-induced oxidative stress suppresses hepcidin expression through increased histone deacetylase activity

(2008) Kouichi Miura et al.   HEPATOLOGY

Bioavailability and Kinetics of Sulforaphane in Humans after Consumption of Cooked versus Raw Broccoli

(2008) Martijn Vermeulen et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

HDAC1 Cooperates with C/EBPα in the Inhibition of Liver Proliferation in Old Mice

(2008) Guo-Li Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nrf1 and Nrf2 Play Distinct Roles in Activation of Antioxidant Response Element-dependent Genes

(2008) Makiko Ohtsuji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HDAC1 Promotes Liver Proliferation in Young Mice via Interactions with C/EBPβ

(2008) Guo-Li Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prognostic role of global DNA-methylation and histone acetylation in pT1a clear cell renal carcinoma in partial nephrectomy specimens

(2008) D. Minardi et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Targeting histone deacetylases for the treatment of disease

(2008) M. W. Lawless et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Proteomics of Human Lung Tissue Identifies Surfactant Protein A as a Marker of Chronic Obstructive Pulmonary Disease

(2008) Steffen Ohlmeier et al.   JOURNAL OF PROTEOME RESEARCH

Prognostic significance of global histone modifications in resected squamous cell carcinoma of the esophagus

(2008) Ching Tzao et al.   MODERN PATHOLOGY

Viral infection and iron metabolism

(2008) Hal Drakesmith et al.   NATURE REVIEWS MICROBIOLOGY

The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men

(2008) Xiang-Jiao Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hepatitis B virus X protein induces the expression of MTA1 and HDAC1, which enhances hypoxia signaling in hepatocellular carcinoma cells

(2008) Y-G Yoo et al.   ONCOGENE

Inhaled corticosteroids and risk of lung cancer among COPD patients who quit smoking

(2008) Victor A. Kiri et al.   RESPIRATORY MEDICINE

Altered Nrf2/Keap1-Bach1 equilibrium in pulmonary emphysema

(2008) D Goven et al.   THORAX

A pervasive role of histone acetyltransferases and deacetylases in an NF-κB-signaling code

(2008) Miriam Calao et al.   TRENDS IN BIOCHEMICAL SCIENCES

Hepatitis B virus-X protein recruits histone deacetylase 1 to repress insulin-like growth factor binding protein 3 transcription

(2008) Jin Kyung Shon et al.   VIRUS RESEARCH

Cellular DNA repair cofactors affecting hepatitis B virus infection and replication

(2008) Fan Zhao et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Hypoxia, angiogenesis, and lung cancer

(2008) Ranjit K. Goudar et al.   Current Oncology Reports

Hepatitis C Virus–Induced Reactive Oxygen Species Raise Hepatic Iron Level in Mice by Reducing Hepcidin Transcription

(2007) Sohji Nishina et al.   GASTROENTEROLOGY