Non-cell-autonomous signaling by Shh in tumors: challenges and opportunities for therapeutic targets

Patched regulates Smoothened trafficking using lipoprotein-derived lipids

(2009) H. Khaliullina et al.   DEVELOPMENT

Hedgehog-Gli Signaling Pathway Inhibitors as Anticancer Agents

(2009) Neeraj Mahindroo et al.   JOURNAL OF MEDICINAL CHEMISTRY

A small molecule that binds Hedgehog and blocks its signaling in human cells

(2009) Benjamin Z Stanton et al.   Nature Chemical Biology

Dual and opposing roles of primary cilia in medulloblastoma development

(2009) Young-Goo Han et al.   NATURE MEDICINE

Primary cilia can both mediate and suppress Hedgehog pathway–dependent tumorigenesis

(2009) Sunny Y Wong et al.   NATURE MEDICINE

Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP

(2009) Benjamin Bishop et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling

(2009) Ivan Bosanac et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Treatment of Medulloblastoma with Hedgehog Pathway Inhibitor GDC-0449

(2009) Charles M. Rudin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inhibition of the Hedgehog Pathway in Advanced Basal-Cell Carcinoma

(2009) Daniel D. Von Hoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Sonic Hedgehog pathway stimulates prostate tumor growth by paracrine signaling and recapitulates embryonic gene expression in tumor myofibroblasts

(2009) A Shaw et al.   ONCOGENE

Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus

(2009) J. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Smoothened Mutation Confers Resistance to a Hedgehog Pathway Inhibitor in Medulloblastoma

(2009) R. L. Yauch et al.   SCIENCE

The decoupling of Smoothened from Gαi proteins has little effect on Gli3 protein processing and Hedgehog-regulated chick neural tube patterning

(2008) Wee-Chuang Low et al.   DEVELOPMENTAL BIOLOGY

Hhat Is a Palmitoylacyltransferase with Specificity forN-Palmitoylation of Sonic Hedgehog

(2008) John A. Buglino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A paracrine requirement for hedgehog signalling in cancer

(2008) Robert L. Yauch et al.   NATURE

Leukotriene Synthesis Is Required for Hedgehog-Dependent Neurite Projection in Neuralized Embryoid Bodies but Not for Motor Neuron Differentiation

(2008) Maarten F. Bijlsma et al.   STEM CELLS