Manipulation of indoleamine 2,3 dioxygenase; a novel therapeutic target for treatment of diseases

Cutting Edge: Autocrine TGF-  Sustains Default Tolerogenesis by IDO-Competent Dendritic Cells

(2014) M. L. Belladonna et al.   JOURNAL OF IMMUNOLOGY

MUC1 Enhances Tumor Progression and Contributes Toward Immunosuppression in a Mouse Model of Spontaneous Pancreatic Adenocarcinoma

(2014) T. L. Tinder et al.   JOURNAL OF IMMUNOLOGY

IL-17 and Therapeutic Kynurenines in Pathogenic Inflammation to Fungi

(2014) L. Romani et al.   JOURNAL OF IMMUNOLOGY

The Indoleamine 2,3-Dioxygenase Pathway Is Essential for Human Plasmacytoid Dendritic Cell-Induced Adaptive T Regulatory Cell Generation

(2014) W. Chen et al.   JOURNAL OF IMMUNOLOGY

Therapeutic effect of exosomes from indoleamine 2,3-dioxygenase-positive dendritic cells in collagen-induced arthritis and delayed-type hypersensitivity disease models

(2009) Nicole R. Bianco et al.   ARTHRITIS AND RHEUMATISM

Chronic granulomatous disease

(2009) B. H. Segal et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A Novel Cancer Therapy by Skin Delivery of Indoleamine 2,3-Dioxygenase siRNA

(2009) M.-C. Yen et al.   CLINICAL CANCER RESEARCH

Intralesional Regulatory T-Cell Suppressive Function during Human Acute and Chronic Cutaneous Leishmaniasis Due to Leishmania guyanensis

(2009) E. Bourreau et al.   INFECTION AND IMMUNITY

Overexpression of indoleamine dioxygenase in rat liver allografts using a high-efficiency adeno-associated virus vector does not prevent acute rejection

(2009) Jerome M. Laurence et al.   LIVER TRANSPLANTATION

TGF-β and kynurenines as the key to infectious tolerance

(2009) Maria L. Belladonna et al.   TRENDS IN MOLECULAR MEDICINE

Overexpression of Indoleamine 2,3-Dioxygenase in Human Endometrial Carcinoma Cells Induces Rapid Tumor Growth in a Mouse Xenograft Model

(2008) N. Yoshida et al.   CLINICAL CANCER RESEARCH

Inverse Correlation between Tumoral Indoleamine 2,3-Dioxygenase Expression and Tumor-Infiltrating Lymphocytes in Endometrial Cancer: Its Association with Disease Progression and Survival

(2008) K. Ino et al.   CLINICAL CANCER RESEARCH

The role of tryptophan catabolism in acquisition and effector function of memory T cells

(2008) Hehua Dai et al.   Current Opinion in Organ Transplantation

Expression of Immunoregulatory Molecules by Thyrocytes Protects Nonobese Diabetic-H2h4Mice from Developing Autoimmune Thyroiditis

(2008) Mami Nakahara et al.   ENDOCRINOLOGY

High expression of indoleamine 2,3-dioxygenase gene in prostate cancer

(2008) Chantal Feder-Mengus et al.   EUROPEAN JOURNAL OF CANCER

Manipulation of indoleamine 2,3-dioxygenase (IDO) for clinical transplantation: promises and challenges

(2008) Jianchao Quan et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

More trouble ahead; is gene therapy coming of age?

(2008) PH Tan et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Interaction of current cancer treatments and the immune system: implications for breast cancer therapeutics

(2008) Peng H Tan et al.   EXPERT OPINION ON PHARMACOTHERAPY

Antimicrobial and immunoregulatory effects mediated by human lung cells: role of IFN-γ-induced tryptophan degradation

(2008) Kathrin Heseler et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Immunosuppressive effect of IDO on T cells in patients with chronic hepatitis B

(2008) Yong-bing Chen et al.   HEPATOLOGY RESEARCH

Immunomodulatory effects of Turkish propolis: Changes in neopterin release and tryptophan degradation

(2008) Gozde Girgin et al.   IMMUNOBIOLOGY

Indoleamine 2,3-dioxygenase in T-cell tolerance and tumoral immune escape

(2008) Jessica B. Katz et al.   IMMUNOLOGICAL REVIEWS

Modulation of invariant natural killer T cell cytokine responses by indoleamine 2,3-dioxygenase

(2008) Alberto Molano et al.   IMMUNOLOGY LETTERS

Effect of 3-hydroxyanthranilic acid in the immunosuppressive molecules indoleamine dioxygenase and HLA-G in macrophages

(2008) Ana S. López et al.   IMMUNOLOGY LETTERS

Indoleamine 2,3-dioxygenase–dependent tryptophan metabolites contribute to tolerance induction during allergen immunotherapy in a mouse model

(2008) Yousef A. Taher et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Der p 1 suppresses indoleamine 2, 3-dioxygenase in dendritic cells from house dust mite–sensitive patients with asthma

(2008) Kittipong Maneechotesuwan et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Cytochromeb5, Not Superoxide Anion Radical, Is a Major Reductant of Indoleamine 2,3-Dioxygenase in Human Cells

(2008) Ghassan J. Maghzal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Curcumin Suppresses the Induction of Indoleamine 2,3-Dioxygenase by Blocking the Janus-activated Kinase-Protein Kinase Cδ-STAT1 Signaling Pathway in Interferon-γ-stimulated Murine Dendritic Cells

(2008) Young-Il Jeong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Indoleamine 2,3-Dioxygenase Is the Anticancer Target for a Novel Series of Potent Naphthoquinone-Based Inhibitors

(2008) Sanjeev Kumar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure Based Development of Phenylimidazole-Derived Inhibitors of Indoleamine 2,3-Dioxygenase

(2008) Sanjeev Kumar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Expression of Indoleamine 2,3-Dioxygenase in Metastatic Pancreatic Ductal Adenocarcinoma Recruits Regulatory T Cells to Avoid Immune Detection

(2008) Agnes Witkiewicz et al.   JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS

Potenzieller endogener, immunologischer Schutzmechanismus uvealer Melanome durch Indoleamine 2,3-Dioxygenase

(2008) S Beutelspacher et al.   KLINISCHE MONATSBLATTER FUR AUGENHEILKUNDE

Indoleamine 2,3-dioxygenase activity of acute myeloid leukemia cells can be measured from patients’ sera by HPLC and is inducible by IFN-γ

(2008) Selim Corm et al.   LEUKEMIA RESEARCH

Indoleamine 2,3-dioxygenase is highly expressed in human adult T-cell leukemia/lymphoma and chemotherapy changes tryptophan catabolism in serum and reduced activity

(2008) Masato Hoshi et al.   LEUKEMIA RESEARCH

Critical role of indoleamine 2,3-dioxygenase in tumor resistance to repeated treatments with targeted IFN 

(2008) A. M. Gasparri et al.   MOLECULAR CANCER THERAPEUTICS

Evolving immunosuppressive microenvironment during human cervical carcinogenesis

(2008) A Kobayashi et al.   Mucosal Immunology

Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease

(2008) Luigina Romani et al.   NATURE

Biomimetic synthesis of the IDO inhibitors exiguamine A and B

(2008) Matthew Volgraf et al.   Nature Chemical Biology

SOCS3 drives proteasomal degradation of indoleamine 2,3-dioxygenase (IDO) and antagonizes IDO-dependent tolerogenesis

(2008) C. Orabona et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chronic inflammation that facilitates tumor progression creates local immune suppression by inducing indoleamine 2,3 dioxygenase

(2008) A. J. Muller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Generation of T cell regulatory activity by plasmacytoid dendritic cells and tryptophan catabolism

(2007) Paolo Puccetti et al.   BLOOD CELLS MOLECULES AND DISEASES