Journal
EXPERT OPINION ON THERAPEUTIC TARGETS
Volume 13, Issue 3, Pages 363-379Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1517/14728220902762910
Keywords
metastatic colorectal cancer; phage display; targeted therapy
Categories
Funding
- Italian Association for Cancer Research (AIRC)
- National Cancer Institute and the Department of Defense
Ask authors/readers for more resources
Background: Colorectal cancer is a leading cause of tumor death, a consequence primarily of the spreading of malignant cells to liver and lung. Despite a range of interventions for liver metastases, the present knowledge of few specific molecular targets may contribute to late diagnosis and poorly effective therapy. Objective: To review the most innovative methodology employed to profile the signature(s) of metastatic colorectal cancer (mCRC) and to address diagnostic/therapeutic agents. Methods: A broad range Medline search was conducted, with particular attention to the search terms 'liver metastasis signature', in combination with 'targeting' and 'nanotechnology'. Results/conclusions: Studies aimed at the discovery of molecular signatures of cancers and metastasis are ongoing; the future of cancer/metastasis targeting is nanoparticle-mediated drug delivery.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available