4.4 Article

Measurement of peritoneal fluid urea nitrogen and creatinine levels is useful to detect iatrogenic urinary tract leakage in colorectal surgery

Journal

JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
Volume 78, Issue 5, Pages 283-286

Publisher

ELSEVIER TAIWAN
DOI: 10.1016/j.jcma.2015.01.006

Keywords

creatinine; peritoneal fluid; urea nitrogen; urinary tract leakage

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Background: Increased peritoneal drainage after colorectal surgery is a common problem. Measurement of peritoneal fluid urea nitrogen (UN) and creatinine (Cr) is a diagnostic tool to detect the urinary tract leakage (UTL). We evaluated its application in colorectal surgery. Methods: We conducted a retrospective chart review study. We enrolled patients with iatrogenic UTL, and measured their UN and Cr levels in peritoneal fluid and compared them with those in blood and urine. Meanwhile, we assigned patients without UTL to a control group and compared clinical parameters of both groups. Results: Twenty-three patients with iatrogenic UTL were recruited. The overall incidence was 0.5%. UN level in peritoneal fluid (322 +/- 56 mg/dL) was significantly higher than that in blood (18.7 +/- 4.0 mg/dL, p < 0.001); Cr level in peritoneal fluid (69.7 +/- 14.3 mg/dL) was also significantly higher than that in blood (1.5 +/- 0.5 mg/dL, p < 0.001). UN level in peritoneal fluid was significantly higher in the iatrogenic UTL group than in the control group (322 mL/dL vs. 9.3 mL/dL, p < 0.001); Cr level in peritoneal fluid was also significantly higher (69.7 mg/dL vs. 0.98 mg/dL, p < 0.001). Conclusion: When increased peritoneal drainage is found postoperatively in colorectal surgery, measurement of UN and Cr levels in peritoneal fluid can be a useful diagnostic tool to determine intraperitoneal iatrogenic UTL. Copyright (C) 2015 Elsevier Taiwan LLC and the Chinese Medical Association. All rights reserved.

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