Sirtuin modulators: an updated patent review (2012 – 2014)

Metformin modulates hyperglycaemia-induced endothelial senescence and apoptosis through SIRT1

(2013) Gnanapragasam Arunachalam et al.   BRITISH JOURNAL OF PHARMACOLOGY

SIRT2: Tumour suppressor or tumour promoter in operable breast cancer?

(2013) Liane M. McGlynn et al.   EUROPEAN JOURNAL OF CANCER

SIRT4 Coordinates the Balance between Lipid Synthesis and Catabolism by Repressing Malonyl CoA Decarboxylase

(2013) Gaëlle Laurent et al.   MOLECULAR CELL

SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine

(2013) Hong Jiang et al.   NATURE

Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators

(2013) B. P. Hubbard et al.   SCIENCE

Forever young: SIRT3 a shield against mitochondrial meltdown, aging, and neurodegeneration

(2013) Brad Kincaid et al.   Frontiers in Aging Neuroscience

Janus-faced role of SIRT1 in tumorigenesis

(2012) Na-Young Song et al.   Annals of the New York Academy of Sciences

SIRT6 Puts Cancer Metabolism in the Driver’s Seat

(2012) Costas A. Lyssiotis et al.   CELL

The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism

(2012) Carlos Sebastián et al.   CELL

The guardian: metabolic and tumour-suppressive effects of SIRT6

(2012) Batya Lerrer et al.   EMBO JOURNAL

SIRT3 Functions in the Nucleus in the Control of Stress-Related Gene Expression

(2012) T. Iwahara et al.   MOLECULAR AND CELLULAR BIOLOGY

SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation

(2012) Matthew F. Barber et al.   NATURE

Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway

(2011) Hyunkyung Jeong et al.   NATURE MEDICINE

Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase

(2011) J. Du et al.   SCIENCE

SIRT1 Activation by Small Molecules

(2010) Han Dai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1

(2010) Michelle Pacholec et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Viral genome silencing by neuronal sirtuin 1

(2010) Kelly E. Picchione et al.   JOURNAL OF NEUROVIROLOGY

SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis

(2010) Ruth Luthi-Carter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Critical Role of the Class III Histone Deacetylase SIRT1 in Cancer

(2009) T. Liu et al.   CANCER RESEARCH

Resveratrol inhibited Tat-induced HIV-1 LTR transactivation via NAD+-dependent SIRT1 activity

(2009) Hong-Sheng Zhang et al.   LIFE SCIENCES