Non-peptidic δ opioid receptor agonists and antagonists (2000 – 2012)

Identification of a dual δ OR antagonist/μ OR agonist as a potential therapeutic for diarrhea-predominant Irritable Bowel Syndrome (IBS-d)

(2012) Henry J. Breslin et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Modulation of gastrointestinal function by MuDelta, a mixed µ opioid receptor agonist/ µ opioid receptor antagonist

(2012) PR Wade et al.   BRITISH JOURNAL OF PHARMACOLOGY

Current Research on Opioid Receptor Function

(2012) Yuan Feng et al.   CURRENT DRUG TARGETS

14-Alkoxy- and 14-Acyloxypyridomorphinans: μ Agonist/δ Antagonist Opioid Analgesics with Diminished Tolerance and Dependence Side Effects

(2012) Subramaniam Ananthan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure of the δ-opioid receptor bound to naltrindole

(2012) Sébastien Granier et al.   NATURE

Structure of the human κ-opioid receptor in complex with JDTic

(2012) Huixian Wu et al.   NATURE

Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic

(2012) Aaron A. Thompson et al.   NATURE

Crystal structure of the µ-opioid receptor bound to a morphinan antagonist

(2012) Aashish Manglik et al.   NATURE

The novel δ opioid receptor agonist KNT-127 produces antidepressant-like and antinociceptive effects in mice without producing convulsions

(2011) Akiyoshi Saitoh et al.   BEHAVIOURAL BRAIN RESEARCH

Opioid δ1 receptor antagonist 7-benzylidenenaltrexone as an effective resistance reverser for chloroquine-resistant Plasmodium chabaudi

(2011) Yoshinori Miyata et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Multiparameter exploration of piperazine derivatives as δ-opioid receptor agonists for CNS indications

(2011) John P. McCauley et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

4-Piperidin-4-ylidenemethyl-benzamides as δ-opioid receptor agonists for CNS indications: Identifying clinical candidates

(2011) Cathy L. Dantzman et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Delta opioid peptide [d-Ala2, d-Leu5] enkephalin (DADLE) triggers postconditioning against transient forebrain ischemia

(2011) Shuyan Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Preclinical Pharmacology of AZD2327: A Highly Selective Agonist of the  -Opioid Receptor

(2011) T. J. Hudzik et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Spinal activation of delta opioid receptors alleviates cancer-related bone pain

(2011) V. Otis et al.   NEUROSCIENCE

The delta opioid receptor: an evolving target for the treatment of brain disorders

(2011) Amynah A. Pradhan et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Design and synthesis of KNT-127, a δ-opioid receptor agonist effective by systemic administration

(2010) Hiroshi Nagase et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A Bastadin with Potent and Selective δ-Opioid Receptor Binding Affinity from the Australian SpongeIanthella flabelliformis

(2010) Anthony R. Carroll et al.   JOURNAL OF NATURAL PRODUCTS

Hasubanan Alkaloids with δ-Opioid Binding Affinity from the Aerial Parts ofStephania japonica

(2010) Anthony R. Carroll et al.   JOURNAL OF NATURAL PRODUCTS

Ex vivo delta opioid receptor autoradiography: CNS receptor occupancy of two novel compounds over their antihyperalgesic dose range

(2010) Ellen E. Codd et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Novel delta opioid receptor agonists exhibit differential stimulation of signaling pathways

(2009) Youyi Peng et al.   BIOORGANIC & MEDICINAL CHEMISTRY

N,N-Diethyl-4-[(3-hydroxyphenyl)(piperidin-4-yl)amino] benzamide derivatives: The development of diaryl amino piperidines as potent δ opioid receptor agonists with in vivo anti-nociceptive activity in rodent models

(2009) Paul Jones et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design and synthesis of novel delta opioid receptor agonists and their pharmacologies

(2009) Hiroshi Nagase et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Biaryl piperidines as potent and selective delta opioid receptor ligands

(2009) Spiros Liras et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and Pharmacological Evaluation of SNC80 Analogues with a Bridged Piperazine Ring

(2009) Ralph Holl et al.   ChemMedChem

Opiates as Antidepressants

(2009) Esther Berrocoso et al.   CURRENT PHARMACEUTICAL DESIGN

Spirocyclic Delta Opioid Receptor Agonists for the Treatment of Pain: Discovery ofN,N-Diethyl-3-hydroxy-4-(spiro[chromene-2,4′-piperidine]-4-yl) Benzamide (ADL5747)

(2009) Bertrand Le Bourdonnec et al.   JOURNAL OF MEDICINAL CHEMISTRY

JNJ-20788560 [9-(8-Azabicyclo[3.2.1]oct-3-ylidene)-9H-xanthene-3-carboxylic Acid Diethylamide], a Selective Delta Opioid Receptor Agonist, Is a Potent and Efficacious Antihyperalgesic Agent That Does Not Produce Respiratory Depression, Pharmacologic Tolerance, or Physical Dependence

(2009) E. E. Codd et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Synthesis and pharmacological evaluation of bicyclic SNC80 analogues with separated benzhydryl moiety

(2008) Bettina Jung et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design and synthesis of a metabolically stable and potent antitussive agent, a novel δ opioid receptor antagonist, TRK-851

(2008) Satoshi Sakami et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Structure−Antitussive Activity Relationships of Naltrindole Derivatives. Identification of Novel and Potent Antitussive Agents

(2008) Satoshi Sakami et al.   JOURNAL OF MEDICINAL CHEMISTRY

Potent, Orally Bioavailable Delta Opioid Receptor Agonists for the Treatment of Pain: Discovery ofN,N-Diethyl-4-(5-hydroxyspiro[chromene-2,4′-piperidine]-4-yl)benzamide (ADL5859)

(2008) Bertrand Le Bourdonnec et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mechanistic Investigation of N,N-Diethyl-4-(phenyl-piperidin-4-ylidenemethyl)-benzamide–Induced Insulin Depletion in the Rat and RINm5F Cells

(2008) Monicah A. Otieno et al.   TOXICOLOGICAL SCIENCES

Antidepressant-like effects of the delta-opioid receptor agonist SNC80 ([(+)-4-[(alphaR)-alpha-[(2S,5R)-2,5-dimethyl-4-(2-propenyl)-1-piperazinyl]-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide) in an olfactory bulbectomized rat model

(2007) Akiyoshi Saitoh et al.   BRAIN RESEARCH