BACE2 as a new diabetes target: a patent review (2010 – 2012)

Correction: Rare Variants in APP, PSEN1 and PSEN2 Increase Risk for AD in Late-Onset Alzheimer's Disease Families

(2014) Carlos Cruchaga et al.   PLoS One

The worldwide diabetes epidemic

(2013) David W. Lam et al.   Current Opinion in Endocrinology Diabetes and Obesity

InChI in the wild: an assessment of InChIKey searching in Google

(2013) Christopher Southan   Journal of Cheminformatics

Tmem27 dimerization, deglycosylation, plasma membrane depletion, and the extracellular Phe-Phe motif are negative regulators of cleavage by Bace2

(2012) Daria Esterházy et al.   BIOLOGICAL CHEMISTRY

BACE1 Dependent Neuregulin Processing: Review

(2012) Daniel Fleck et al.   Current Alzheimer Research

Small-molecule BACE1 inhibitors: a patent literature review (2006 – 2011)

(2012) Gary Probst et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Identification of BACE2 as an avid ß-amyloid-degrading protease

(2012) Samer O Abdul-Hay et al.   Molecular Neurodegeneration

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

(2012) Thorlakur Jonsson et al.   NATURE

Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice

(2011) Paul J. Meakin et al.   BIOCHEMICAL JOURNAL

Bace2 Is a β Cell-Enriched Protease that Regulates Pancreatic β Cell Function and Mass

(2011) Daria Esterházy et al.   Cell Metabolism

Developing β-secretase inhibitors for treatment of Alzheimer’s disease

(2011) Arun K. Ghosh et al.   JOURNAL OF NEUROCHEMISTRY

Analysis of in vitro bioactivity data extracted from drug discovery literature and patents: Ranking 1654 human protein targets by assayed compounds and molecular scaffolds

(2011) Christopher Southan et al.   Journal of Cheminformatics

BACE2 plays a role in the insulin receptor trafficking in pancreatic β-cells

(2010) Silvia Casas et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

BACE2 is Stored in Secretory Granules of Mouse and Rat Pancreatic β Cells

(2009) Giovanna Finzi et al.   ULTRASTRUCTURAL PATHOLOGY