Hypoxia-inducible factor inhibitors: a survey of recent patented compounds (2004 – 2010)

LW6, a novel HIF-1 inhibitor, promotes proteasomal degradation of HIF-1α via upregulation of VHL in a colon cancer cell line

(2010) Kyeong Lee et al.   BIOCHEMICAL PHARMACOLOGY

A novel steroidal inhibitor of estrogen-related receptor α (ERRα)

(2010) Sarah J. Duellman et al.   BIOCHEMICAL PHARMACOLOGY

Development of novel inhibitors targeting HIF-1α towards anticancer drug discovery

(2010) Nilambari Yewalkar et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Boron-containing phenoxyacetanilide derivatives as hypoxia-inducible factor (HIF)-1α inhibitors

(2010) Kazuki Shimizu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

FM19G11: A new modulator of HIF that links mTOR activation with the DNA damage checkpoint pathways

(2010) Francisco Javier Rodríguez-Jiménez et al.   CELL CYCLE

Safety, Efficacy, Pharmacokinetics, and Pharmacodynamics of the Combination of Sorafenib and Tanespimycin

(2010) U. N. Vaishampayan et al.   CLINICAL CANCER RESEARCH

Prolyl hydroxylase domain-containing protein inhibitors as stabilizers of hypoxia-inducible factor: small molecule-based therapeutics for anemia

(2010) Lin Yan et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Neratinib, an Irreversible Pan-ErbB Receptor Tyrosine Kinase Inhibitor: Results of a Phase II Trial in Patients With Advanced Non–Small-Cell Lung Cancer

(2010) Lecia V. Sequist et al.   JOURNAL OF CLINICAL ONCOLOGY

Identification of HSP60 as a Primary Target ofo-Carboranylphenoxyacetanilide, an HIF-1α Inhibitor

(2010) Hyun Seung Ban et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inhibition of PI3K by PX-866 Prevents Transforming Growth Factor-α–Induced Pulmonary Fibrosis

(2009) Timothy D. Le Cras et al.   AMERICAN JOURNAL OF PATHOLOGY

A novel benzimidazole analogue inhibits the hypoxia-inducible factor (HIF)-1 pathway

(2009) Mi-Sun Won et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

FM19G11, a New Hypoxia-inducible Factor (HIF) Modulator, Affects Stem Cell Differentiation Status

(2009) Victoria Moreno-Manzano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The selective hypoxia inducible factor-1 inhibitor PX-478 provides in vivo radiosensitization through tumor stromal effects

(2009) D. L. Schwartz et al.   MOLECULAR CANCER THERAPEUTICS

Targeting the phosphoinositide 3-kinase pathway in cancer

(2009) Pixu Liu et al.   NATURE REVIEWS DRUG DISCOVERY

A RNA antagonist of hypoxia-inducible factor-1 , EZN-2968, inhibits tumor cell growth

(2008) L. M. Greenberger et al.   MOLECULAR CANCER THERAPEUTICS