Tachykinin neurokinin 3 receptor antagonists: a patent review (2005 – 2010)

Discovery of potent, balanced and orally active dual NK1/NK3 receptor ligands

(2010) Jens-Uwe Peters et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Rational design of novel pyrrolidine derivatives as orally active neurokinin-3 receptor antagonists

(2010) Hassen Ratni et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Neurokinin B and the hypothalamic regulation of reproduction

(2010) Naomi E. Rance et al.   BRAIN RESEARCH

Neurokinin B Stimulates GnRH Release in the Male Monkey (Macaca mulatta) and Is Colocalized with Kisspeptin in the Arcuate Nucleus

(2010) Suresh Ramaswamy et al.   ENDOCRINOLOGY

Future Prospects for Luteinizing Hormone-Releasing Hormone Analogues in Prostate Cancer Treatment

(2010) Hideyuki Akaza   PHARMACOLOGY

Characterization of species-related differences in the pharmacology of tachykinin NK receptors 1, 2 and 3

(2009) Agnes Leffler et al.   BIOCHEMICAL PHARMACOLOGY

Therapeutic Utility of NK3 Receptor Antagonists for the Treatment of Schizophrenia

(2009) Lee Dawson et al.   CURRENT PHARMACEUTICAL DESIGN

In vitro and in vivo comparison of two non-peptide tachykinin NK3 receptor antagonists: Improvements in efficacy achieved through enhanced brain penetration or altered pharmacological characteristics

(2009) Lee A. Dawson et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Luteinizing hormone-releasing hormone (LHRH) agonists in the treatment of breast cancer

(2009) Allan Hackshaw   EXPERT OPINION ON PHARMACOTHERAPY

Identification of a Critical Residue in the Transmembrane Domain 2 of Tachykinin Neurokinin 3 Receptor Affecting the Dissociation Kinetics and Antagonism Mode of Osanetant (SR 142801) and Piperidine-Based Structures

(2009) Pari Malherbe et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ligand binding and micro-switches in 7TM receptor structures

(2009) Rie Nygaard et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

New quinoline NK3 receptor antagonists with CNS activity

(2008) Paul W. Smith et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Guide to Receptors and Channels (GRAC), 3rd edition

(2008) S P H Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Psychomotor and cognitive effects of a single oral dose of talnetant (SB223412) in healthy volunteers compared with placebo or haloperidol

(2008) M. Liem-Moolenaar et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Me-Talnetant and Osanetant Interact within Overlapping but Not Identical Binding Pockets in the Human Tachykinin Neurokinin 3 Receptor Transmembrane Domains

(2008) P. Malherbe et al.   MOLECULAR PHARMACOLOGY

TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokinin B in the central control of reproduction

(2008) A Kemal Topaloglu et al.   NATURE GENETICS

Cognitive performance in neurokinin 3 receptor knockout mice

(2008) R. E. Nordquist et al.   PSYCHOPHARMACOLOGY