Orexin receptor antagonists: a review of promising compounds patented since 2006

Discovery of a Potent, CNS-Penetrant Orexin Receptor Antagonist Based on anN,N-Disubstituted-1,4-diazepane Scaffold that Promotes Sleep in Rats

(2009) David B. Whitman et al.   ChemMedChem

Biomedical Application of Orexin/Hypocretin Receptor Ligands in Neuroscience

(2009) Christoph Boss et al.   JOURNAL OF MEDICINAL CHEMISTRY

Blockade of Orexin-1 Receptors Attenuates Orexin-2 Receptor Antagonism-Induced Sleep Promotion in the Rat

(2009) C. Dugovic et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Proline bis-amides as potent dual orexin receptor antagonists

(2008) Jeffrey M. Bergman et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The signalling profile of recombinant human orexin-2 receptor

(2008) Jiyou Tang et al.   CELLULAR SIGNALLING

Orexin Receptor Antagonism: A New Principle in Neuroscience

(2008) Christoph Boss et al.   CHIMIA

Orexin Receptor Antagonists: Medicinal Chemistry and Therapeutic Potential

(2008) Anthony Roecker et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Role of lateral hypothalamic orexin neurons in reward processing and addiction

(2008) Gary Aston-Jones et al.   NEUROPHARMACOLOGY