Small molecule c-Met kinase inhibitors: a review of recent patents

From Concept to Reality: The Long Road to c-Met and RON Receptor Tyrosine Kinase Inhibitors for the Treatment of Cancer

(2012) Isabelle Dussault et al.   Anti-Cancer Agents in Medicinal Chemistry

Enzymatic Characterization of c-Met Receptor Tyrosine Kinase Oncogenic Mutants and Kinetic Studies with Aminopyridine and Triazolopyrazine Inhibitors

(2009) Sergei L. Timofeevski et al.   BIOCHEMISTRY

Discovery of 4-azaindoles as novel inhibitors of c-Met kinase

(2009) John Porter et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

N-(3-fluoro-4-(2-arylthieno[3,2-b]pyridin-7-yloxy)phenyl)-2-oxo-3-phenylimidazolidine-1-carboxamides: A novel series of dual c-Met/VEGFR2 receptor tyrosine kinase inhibitors

(2009) Stéphane Raeppel et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The MET Receptor Tyrosine Kinase Is a Potential Novel Therapeutic Target for Head and Neck Squamous Cell Carcinoma

(2009) T. Y. Seiwert et al.   CANCER RESEARCH

Discovery ofN-(4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a Selective and Orally Efficacious Inhibitor of the Met Kinase Superfamily

(2009) Gretchen M. Schroeder et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of pyrrolo[2,1-f][1,2,4]triazine-based inhibitors of Met kinase

(2008) Gretchen M. Schroeder et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of orally active pyrrolopyridine- and aminopyridine-based Met kinase inhibitors

(2008) Zhen-Wei Cai et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of a novel and potent series of thieno[3,2-b]pyridine-based inhibitors of c-Met and VEGFR2 tyrosine kinases

(2008) Stephen Claridge et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of a novel series of quinoxalines as inhibitors of c-Met kinase

(2008) John Porter et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Chemical Reactivity of Methoxy 4-O-Aryl Quinolines: Identification of Glutathione Displacement Products in Vitro and in Vivo

(2008) Yohannes Teffera et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Small-molecule inhibitors binding to protein kinase. Part II: the novel pharmacophore approach of type II and type III inhibition

(2008) AC Backes et al.   Expert Opinion on Drug Discovery

Small-molecule inhibitors binding to protein kinases. Part I: exceptions from the traditional pharmacophore approach of type I inhibition

(2008) AC Backes et al.   Expert Opinion on Drug Discovery

Targeting the c-MET signaling pathway for cancer therapy

(2008) Xiangdong Liu et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Prevalence of Secondary Causes of Bone Loss Among Breast Cancer Patients With Osteopenia and Osteoporosis

(2008) Pauline M. Camacho et al.   JOURNAL OF CLINICAL ONCOLOGY

Discovery and Optimization of Triazolopyridazines as Potent and Selective Inhibitors of the c-Met Kinase†

(2008) Brian K. Albrecht et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Pyrrolopyridine−Pyridone Based Inhibitors of Met Kinase: Synthesis, X-ray Crystallographic Analysis, and Biological Activities

(2008) Kyoung Soon Kim et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of a Potent, Selective, and Orally Bioavailable c-Met Inhibitor: 1-(2-Hydroxy-2-methylpropyl)-N-(5-(7-methoxyquinolin-4-yloxy)pyridin-2-yl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide (AMG 458)

(2008) Longbin Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Biological Evaluation of Potent c-Met Inhibitors

(2008) Noel D. D’Angelo et al.   JOURNAL OF MEDICINAL CHEMISTRY

HER kinase activation confers resistance to MET tyrosine kinase inhibition in MET oncogene-addicted gastric cancer cells

(2008) T. Bachleitner-Hofmann et al.   MOLECULAR CANCER THERAPEUTICS

Drug development of MET inhibitors: targeting oncogene addiction and expedience

(2008) Paolo M. Comoglio et al.   NATURE REVIEWS DRUG DISCOVERY