Modulation of neuropeptide Y receptors for the treatment of obesity

Identification of novel and orally active spiroindoline NPY Y5 receptor antagonists

(2009) Toshihiro Sakamoto et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Optimization of a series of 2,4-diaminopyridines as neuropeptide Y Y1 receptor antagonists with reduced hERG activity

(2009) Minoru Kameda et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

NPY Signalling Pathway in Bone Homeostasis: Y1 Receptor as a Potential Drug Target

(2009) D. Sousa et al.   CURRENT DRUG TARGETS

Synergistic interaction between neuropeptide Y1 and Y5 receptor pathways in regulation of energy homeostasis

(2009) Satoshi Mashiko et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Comparison of independent and combined chronic anti-obese effects of NPY Y2 receptor agonist, PYY(3-36), and NPY Y5 receptor antagonist in diet-induced obese mice

(2009) Ryuichi Moriya et al.   PEPTIDES

Effects of different intermittent peptide YY (3-36) dosing strategies on food intake, body weight, and adiposity in diet-induced obese rats

(2008) Roger D. Reidelberger et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Pharmacological characterization and appetite suppressive properties of BMS-193885, a novel and selective neuropeptide Y1 receptor antagonist

(2008) Ildiko Antal-Zimanyi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Neuropeptide Y is produced in visceral adipose tissue and promotes proliferation of adipocyte precursor cells via the Y1 receptor

(2008) Kaiping Yang et al.   FASEB JOURNAL

PYY transgenic mice are protected against diet-induced and genetic obesity

(2008) Dana Boey et al.   NEUROPEPTIDES

Effects of a Novel Y5 Antagonist in Obese Mice: Combination With Food Restriction or Sibutramine

(2008) Satoshi Mashiko et al.   Obesity

Modulation of intracellular calcium changes and glutamate release by neuropeptide Y1 and Y2 receptors in the rat hippocampus: differential effects in CA1, CA3 and dentate gyrus

(2003) Ana P. Silva et al.   JOURNAL OF NEUROCHEMISTRY