Review
Clinical Neurology
Mehmet Kemal Arikan, Reyhan Ilhan, Oliver Pogarell, Baris Metin
Summary: Currently, there is no clear answer regarding the duration of antidepressant use or when it can be safely discontinued. A systematic review of 37 double-blind, randomized placebo-controlled trials found that antidepressants were superior to placebo in preventing relapse during the follow-up phase. However, the duration of treatment was not related to the effect size, suggesting that long-term use may not be justified and may pose risks of adverse effects.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Immunology
Marta Kubera, Beatriz Arteta, Beata Grygier, Katarzyna Curzytek, Stanislaw Malicki, Michael Maes
Summary: This study found that fluoxetine and desipramine can increase the number and volume of liver metastases, while mirtazapine does not have this effect. Additionally, fluoxetine and desipramine can suppress immune defense response, unlike mirtazapine.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Neurosciences
Ole Christian Sylte, Jesper Solheim Johansen, Indrek Heinla, Danielle J. Houwing, Jocelien D. A. Olivier, Roy Heijkoop, Eelke M. S. Snoeren
Summary: The study found that perinatal exposure to fluoxetine affects non-social investigation behaviors of adult rat offspring, particularly leading to a quicker and less detailed investigation strategy in novel environments, with this alteration being more pronounced in females.
PSYCHOPHARMACOLOGY
(2021)
Article
Psychiatry
Mehmet Sarier, Meltem Demir, Mestan Emek, Ali Ozgen, Hasan Turgut, Candan Ozdemir
Summary: The aim of this study was to determine the frequency of hematuria in patients using SSRI/SNRIs and to compare with a control group. The results showed that the prevalence of hematuria was significantly higher in the SSRI/SNRI group compared to the control group.
NORDIC JOURNAL OF PSYCHIATRY
(2023)
Article
Psychiatry
Erum Khan, Ishan Jani, Mainak Bardhan, Mohammad Mehedi Hasan
Summary: The global pandemic of COVID-19 is expanding, and efforts are being made to understand its pathophysiology and discover effective drugs. Recent findings suggest that antidepressant drugs like fluvoxamine and clomipramine, which target excessive inflammation and replication-related proteins, may hold promise in reducing mortality and morbidity in severe COVID patients.
PSYCHIATRIA DANUBINA
(2022)
Review
Medicine, Research & Experimental
Soraya Mouffak, Qamar Shubbar, Ekram Saleh, Raafat El-Awady
Summary: The global COVID-19 pandemic has led to significant mortality and economic consequences. Different stages of the viral life cycle require distinct pharmacological treatments, with drugs targeting viral entry, replication, and inflammation showing promise in ongoing clinical trials. This study aims to summarize current findings and identify gaps in knowledge to shape future COVID-19 treatment research.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Chemistry, Physical
Cristina Trujillo, Pilar Goya, Isabel Rozas
JOURNAL OF PHYSICAL CHEMISTRY A
(2018)
Article
Biochemistry & Molecular Biology
Viola Previtali, Cristina Trujillo, Rebecca Amet, Daniela M. Zisterer, Isabel Rozas
Article
Chemistry, Inorganic & Nuclear
Khalid Mahmood, Waleed Hashmi, Hammad Ismail, Bushra Mirza, Brendan Twamley, Zareen Akhter, Isabel Rozas, Robert J. Baker
Article
Chemistry, Medicinal
Hussain Ullah, Viola Previtali, Helene B. Mihigo, Brendan Twamley, Muhammad Khawar Rauf, Fatima Laved, Amir Waseem, Robert J. Baker, Isabel Rozas
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2019)
Article
Chemistry, Organic
Ranjana Aggarwal, Shilpa Sharma, Mona Hooda, Dionisia Sanz, Rosa M. Claramunt, Brendan Twamley, Isabel Rozas
Article
Chemistry, Medicinal
Michela McMullan, Brendan Kelly, Helene B. Mihigo, Aaron P. Keogh, Fernando Rodriguez, Iria Brocos-Mosquera, Aintzane Garcia-Bea, Patricia Miranda-Azpiazu, Luis F. Callado, Isabel Rozas
Summary: Compounds with excellent receptor engagement and alpha(2)-AR antagonist activity were prepared and tested, leading to the identification of both partial agonists and potent antagonists. Structural studies suggested that antagonism may be achieved by interaction of substituents in the compounds with specific amino acids in the receptor.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Viola Previtali, Helene B. Mihigo, Rebecca Amet, Anthony M. McElligott, Daniela M. Zisterer, Isabel Rozas
Article
Chemistry, Organic
Adeyemi Rahman, Nikolina Stipanicev, Aaron P. Keogh, Brendan Twamley, Isabel Rozas
Summary: The reactivity of carbamates has been studied for producing differently substituted guanidines without the use of strong bases or catalysts. Reactions with alcohols or amines allow for the synthesis of various substituted amidinoureas.
TETRAHEDRON LETTERS
(2021)
Article
Chemistry, Multidisciplinary
Ranjana Aggarwal, Mona Hooda, Naman Jain, Dionisia Sanz, Rosa M. Claramunt, Brendan Twamley, Isabel Rozas
Summary: This article presents an efficient and environmentally friendly method for the synthesis of 2-aryl/hetaryl-4-methyl-5-acylthiazoles under solvent-free conditions, with high functional group tolerance and admirable yields. The structure of the synthesized thiazoles was confirmed using multinuclear NMR and X-ray crystallographic studies.
JOURNAL OF SULFUR CHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Rebecca Amet, Viola Previtali, Helene B. Mihigo, Emily Sheridan, Sarah Brophy, Nadhim Kamil Hante, Maria Jose Santos-Martinez, Patrick J. Hayden, Paul Browne, Isabel Rozas, Anthony M. McElligott, Daniela M. Zisterer
Summary: VP79s is a novel guanidinium-based compound that exhibits cytotoxicity in multiple myeloma cells. It inhibits the IL-6/STAT3 signaling pathway and downregulates MCL-1 expression, resulting in selective anti-tumor activity.
Article
Chemistry, Medicinal
Maria Carmen Costas-Lago, Noemi Vila, Adeyemi Rahman, Pedro Besada, Isabel Rozas, Jose Brea, Maria Isabel Loza, Elisa Gonzalez-Romero, Carmen Teran
Summary: Novel aryl guanidinium analogues containing the pyridazin-3(2H)-one core were proposed as minor groove binders (MGBs) and their potential as DNA binders and anti-cancer agents were investigated. Compounds with a bis-guanidinium structure showed weak DNA binding affinity and exhibited a reasonable inhibitory effect on cancer cell viability.
ACS MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Microbiology
Filippo Prencipe, Aishah Alsibaee, Zainab Khaddem, Padraig Norton, Aisling M. Towell, Afnan F. M. Ali, Gerard Reid, Orla M. Fleury, Timothy J. Foster, Joan A. Geoghegan, Isabel Rozas, Marian P. Brennan
Summary: Colonization of S. aureus can lead to systemic infections, which are difficult to treat due to antibiotic resistance. We have identified a small molecule inhibitor of the S. aureus clumping factors that has potential as a colonization inhibitor.
MICROBIOLOGY SPECTRUM
(2022)
Article
Chemistry, Medicinal
Nikolina Stipanicev, Konstantin Raabe, Isabel Rozas
Summary: Computational studies and biophysical experiments were conducted to improve the binding to guanine quadruplexes of different topologies using porphyrin diphenyl guanidine conjugates with an O or S bridge and a newly designed derivative with an SO2 bridge. The results showed that the new derivative had poor binding to any of the guanine quadruplexes studied, possibly due to the size of the SO2 bridge.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Chemistry, Physical
Cristina Trujillo, Isabel Rozas, Jose Elguero, Ibon Alkorta, Goar Sanchez-Sanz
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2019)
Review
Biochemistry & Molecular Biology
Adeyemi Rahman, Patrick O'Sullivan, Isabel Rozas