Basal cell carcinoma: a paradigm for targeted therapies

Single and multiple dose intravenous and oral pharmacokinetics of the hedgehog pathway inhibitor vismodegib in healthy female subjects

(2012) Richard A. Graham et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Hedgehog inhibitor decreases chemosensitivity to 5-fluorouracil and gemcitabine under hypoxic conditions in pancreatic cancer

(2012) Hideya Onishi et al.   CANCER SCIENCE

Basal cell carcinoma — molecular biology and potential new therapies

(2012) Maria Kasper et al.   JOURNAL OF CLINICAL INVESTIGATION

Hedgehog-GLI Pathway in Medulloblastoma

(2012) Tenley C. Archer et al.   JOURNAL OF CLINICAL ONCOLOGY

Inhibiting the Hedgehog Pathway in Patients with the Basal-Cell Nevus Syndrome

(2012) Jean Y. Tang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Efficacy and Safety of Vismodegib in Advanced Basal-Cell Carcinoma

(2012) Aleksandar Sekulic et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hedgehog Fights Back: Mechanisms of Acquired Resistance against Smoothened Antagonists

(2011) C. Metcalfe et al.   CANCER RESEARCH

A Single Dose Mass Balance Study of the Hedgehog Pathway Inhibitor Vismodegib (GDC-0449) in Humans Using Accelerator Mass Spectrometry

(2011) R. A. Graham et al.   DRUG METABOLISM AND DISPOSITION

Mommy — where do tumors come from?

(2011) Ervin H. Epstein   JOURNAL OF CLINICAL INVESTIGATION

Basal cell carcinomas in mice arise from hair follicle stem cells and multiple epithelial progenitor populations

(2011) Marina Grachtchouk et al.   JOURNAL OF CLINICAL INVESTIGATION

Topical Treatment of Basal Cell Carcinomas in Nevoid Basal Cell Carcinoma Syndrome with a Smoothened Inhibitor

(2011) Hans Skvara et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

A germline variant in the TP53 polyadenylation signal confers cancer susceptibility

(2011) Simon N Stacey et al.   NATURE GENETICS

Emerging Treatments and Signaling Pathway Inhibitors

(2011) Jean Y. Tang et al.   SEMINARS IN CUTANEOUS MEDICINE AND SURGERY

Itraconazole, a Commonly Used Antifungal that Inhibits Hedgehog Pathway Activity and Cancer Growth

(2010) James Kim et al.   CANCER CELL

Small Molecule Inhibition of GDC-0449 Refractory Smoothened Mutants and Downstream Mechanisms of Drug Resistance

(2010) Gerrit J. P. Dijkgraaf et al.   CANCER RESEARCH

Role of high-dose chemotherapy for recurrent medulloblastoma and other CNS primitive neuroectodermal tumors

(2010) Amar Gajjar et al.   PEDIATRIC BLOOD & CANCER

Interfering with Resistance to Smoothened Antagonists by Inhibition of the PI3K Pathway in Medulloblastoma

(2010) S. Buonamici et al.   Science Translational Medicine

GDC-0449—A potent inhibitor of the hedgehog pathway

(2009) Kirk D. Robarge et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Treatment of Medulloblastoma with Hedgehog Pathway Inhibitor GDC-0449

(2009) Charles M. Rudin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inhibition of the Hedgehog Pathway in Advanced Basal-Cell Carcinoma

(2009) Daniel D. Von Hoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Smoothened Mutation Confers Resistance to a Hedgehog Pathway Inhibitor in Medulloblastoma

(2009) R. L. Yauch et al.   SCIENCE

Guidelines for the management of basal cell carcinoma

(2008) N.R. Telfer et al.   BRITISH JOURNAL OF DERMATOLOGY

Acquired resistance to tyrosine kinase inhibitors during cancer therapy

(2008) Jeffrey A Engelman et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Bazex–Dupré–Christol syndrome: An ectodermal dysplasia with skin appendage neoplasms

(2008) Marco Castori et al.   European Journal of Medical Genetics

Short German guidelines: Basal cell carcinoma

(2008) Axel Hauschild et al.   JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT

Pediatric basal cell carcinoma: case reports and literature review

(2008) Philip A. Efron et al.   JOURNAL OF PEDIATRIC SURGERY

A clinical study comparing methyl aminolevulinate photodynamic therapy and surgery in small superficial basal cell carcinoma (8-20 mm), with a 12-month follow-up.

(2008) RM Szeimies et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

A paracrine requirement for hedgehog signalling in cancer

(2008) Robert L. Yauch et al.   NATURE

Nevoid basal cell carcinoma syndrome (Gorlin syndrome)

(2008) Lorenzo Lo Muzio   Orphanet Journal of Rare Diseases

Multiple Basal Cell Carcinomas in Xeroderma Pigmentosum Treated with Imiquimod 5% Cream

(2008) AMIT KUMAR MALHOTRA et al.   PEDIATRIC DERMATOLOGY

Early Events in UV Carcinogenesis—DNA Damage, Target Cells and Mutant p53 Foci

(2008) Frank R. de Gruijl et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Chronic Diseases Requiring Hospitalization and Risk of Non-Melanoma Skin Cancers—A Population Based Study from Denmark

(2007) Annette Ø. Jensen et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY