Article
Cardiac & Cardiovascular Systems
Jules Mesnier, Gregory Ducrocq, Nicolas Danchin, Roberto Ferrari, Ian Ford, Jean-Claude Tardif, Michal Tendera, Kim M. Fox, Philippe Gabriel Steg
Summary: The study found that angina affects almost one-quarter of stable coronary artery disease patients, but resolves without events or coronary revascularization in most cases. Patients whose angina resolved within one year with conservative management had outcomes similar to those without angina, while persistence or occurrence of angina was associated with worse outcomes.
Article
Cardiac & Cardiovascular Systems
Weijing Liu, Ximin Fan, Jianying Shen, Mengyun Zhu, Xuehua Fan, Yawei Xu, Liqiong Hong
Summary: Cardiac shock wave therapy (CSWT) is a non-invasive and safe treatment option for chronic refractory angina pectoris (CRAP) patients, which can improve myocardial perfusion and reduce clinical symptoms without increasing adverse effects.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Panagiotis Theofilis, Evangelos Oikonomou, Marios Sagris, Nikolaos Papageorgiou, Konstantinos Tsioufis, Dimitris Tousoulis
Summary: Coronary artery disease is a prevalent condition with detrimental effects on affected individuals. Stable angina pectoris, its most frequent manifestation, can be challenging to manage despite available treatments. Various approaches have been developed for refractory angina pectoris, with enhanced external counterpulsation and coronary sinus reduction being recognized techniques. Clinical trial results for these techniques are encouraging but limited in sample size. Other intervention methods, such as transmyocardial laser revascularization and spinal cord stimulation, have controversial or negative results. Angiogenic therapy with targeted intramyocardial vascular endothelial growth factor injection or CD34+ cell therapy may be beneficial but further investigation is needed.
CURRENT PHARMACEUTICAL DESIGN
(2023)
Article
Multidisciplinary Sciences
Alyaa Ajabnoor, Amnah Mukhtar
Summary: This study aimed to explore the effect of adding trimetazidine to other anti-anginal drugs on the functional capacity of ischemic heart disease (IHD) patients not suitable for revascularization. The analysis of six randomized controlled trials showed that trimetazidine can improve walking time and severity of angina in these patients.
Editorial Material
Cardiac & Cardiovascular Systems
Dimitrios Farmakis, Andrew Xanthopoulos, Filippos Triposkiadis
Summary: The traditional plaque-centric model of CAD pathophysiology and management has been questioned, leading to a paradigm shift considering the multifactorial aspect of CAD. An alternative medical management approach based on drug properties in relation to myocardial ischemia pathophysiology has been proposed for chronic CAD and stable angina patients, organized into disease-modifying therapy, pathophysiology-based anti-ischaemic therapy, and symptomatic therapy.
HELLENIC JOURNAL OF CARDIOLOGY
(2021)
Review
Medicine, General & Internal
Shuwen Pang, Yajuan Lv, Wenfang Zhong, Jing Qian, Yueli Zhao, Jiahui Zhong, Weiyi Huang
Summary: This study systematically evaluated the clinical effectiveness and safety of electroacupuncture combined with conventional drugs in the treatment of stable angina pectoris. The results showed that compared with drug therapy alone, the combination of electroacupuncture and drug therapy was more effective in improving clinical symptoms, electrocardiography, visual analog score, and Seattle Angina Scale, with a lower incidence of adverse events. However, the limited number of high-quality literature with rigorous study design protocols may introduce bias to the study results, and further clinical trials are needed to verify the conclusions.
Article
Cardiac & Cardiovascular Systems
Tetsuji Morishita, Daisuke Takada, Jung-ho Shin, Susumu Kunisawa, Kiyohide Fushimi, Yuichi Imanaka
Summary: The revision of reimbursement policy in Japan in 2018 led to a significant reduction in elective PCI procedures per month, highlighting the importance of documenting ischaemia in patients with stable angina prior to the procedure.
Review
Cardiac & Cardiovascular Systems
Divaka Perera, Colin Berry, Stephen P. Hoole, Aish Sinha, Haseeb Rahman, Paul D. Morris, Rajesh K. Kharbanda, Ricardo Petraco, Keith Channon
Summary: Nearly half of patients with angina have non-obstructive coronary artery disease (ANOCA), with two-thirds of these patients having coronary microvascular disease (CMD). Impaired coronary flow reserve (CFR) is associated with myocardial ischemia and adverse cardiovascular outcomes. The CMD workstream aims to improve accuracy of diagnosis and treatment through standardized procedures and various assessment methods.
Review
Cardiac & Cardiovascular Systems
Huikai Shao, Yang Huang, Dongsheng Xu, Shengfeng Huang, Rongsheng Tong
Summary: This meta-analysis indicates that puerarin injection is more effective than using conventional Western medicine alone in the treatment of unstable angina pectoris (UAP). However, more evidence is still needed to verify the efficacy of puerarin injection due to the low methodological quality of the included randomized controlled trials (RCTs).
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Dennis Christoph Harrer, Jan Doerrie, Niels Schaft
Summary: The development of CAR-T cells has revolutionized cancer immunotherapy, but there are challenges such as relapse or refractory disease in some patients, especially those with solid tumors. Obstacles to successful CAR-T cell therapy include antigen shutdown and CAR-T cell dysfunctionality. This review highlights different approaches, including combining CAR-T cells with drugs, to overcome these obstacles and improve the efficacy of CAR-T cell therapy in both hematological malignancies and solid tumors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Samer Noaman, David M. Kaye, Shane Nanayakkara, Anthony M. Dart, Andy S. C. Yong, Martin Ng, Donna Vizi, Stephen J. Duffy, Nicholas Cox, William Chan
Summary: This study aimed to evaluate microcirculatory resistance (MR) and myocardial metabolic adaptations in patients with suspected coronary microvascular dysfunction (CMD) at rest and in response to increased cardiac workload. Microcirculatory assessment and transcardiac blood sampling were conducted during graded exercise with adenosine-mediated hyperaemia in patients with objective ischaemia and/or myocardial injury and non-obstructive coronary artery disease. The results showed that patients with suspected CMD exhibited distinct microcirculatory resistive and myocardial metabolic profiles at rest and in response to exercise.
Article
Medicine, General & Internal
Francesco Radico, Augusto Di Castelnuovo, Alberto Aimo, Marco Zimarino, Juhani Knuuti, Serena Rossi, Luigi Emilio Pastormerlo, Luc Zyw, Enrico Orsini, Licia Iacoviello, Danilo Neglia, Michele Emdin, Giovanni de Gaetano, Raffaele De Caterina
Summary: The prognosis of angina patients without obstructive coronary artery disease (CAD) is heterogeneous, with non-obstructive CAD and myocardial ischemia at imaging tests both conferring a higher risk of cardiovascular events.
JOURNAL OF INTERNAL MEDICINE
(2022)
Review
Medicine, General & Internal
Vruti Vithani, Bansi Sutariya, Diana M. Montenegro, Michael Chukwu, Paghunda Ehsan, Rawia N. Aburumman, Shivani Ishwarya Muthanna, Swathi Radhakrishnan Menon, Sai Sri Penumetcha
Summary: Cell therapy using autologous CD34+ stem cells has shown promising results in the treatment of refractory angina, with improvements in coronary blood flow and reduction in nitroglycerin use. Once approved, this treatment has the potential to revolutionize the management and prognosis of refractory angina.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Clinical Neurology
Baijia Li, Yajuan Fan, Binbin Zhao, Lihong Yang, Jian Yang, Xiancang Ma, Bin Yan
Summary: The study found that later bedtimes on both weekdays and weekends were significantly associated with an increased prevalence of angina pectoris (AP), suggesting that early bedtimes may help reduce the risk of AP.
Article
Cardiac & Cardiovascular Systems
Alberto Polimeni, Carmen Spaccarotella, Jessica Ielapi, Giovanni Esposito, Amelia Ravera, Eugenio Martuscelli, Vincenzo Ciconte, Maurizio Menichelli, Ferdinando Varbella, Massimo Imazio, Alessandro Navazio, Gianfranco Sinagra, Rainer Oberhollenzer, Gerolamo Sibilio, Luisa Cacciavillani, Luigi Meloni, Marcello Dominici, Fabrizio Tomai, Francesco Amico, Marco Corda, Giuseppe Musumeci, Alessandro Lupi, Luigi Zezza, Raffaele De Caterina, Carlo Cernetti, Marco Metra, Lidia Rossi, Paolo Calabro, Adriano Murrone, Massimo Volpe, Pasquale Caldarola, Stefano Carugo, Bernardo Cortese, Renato Valenti, Giuseppe Boriani, Francesco Fedele, Giorgio Ventura, Maria Teresa Manes, Angela Rita Colavita, Mauro Feola, Francesco Versaci, Pasquale Assennato, Giuseppe Arena, Roberto Ceravolo, Vincenzo Amodeo, Gianfranco Tortorici, Daniele Nassiacos, Roberto Antonicelli, Nicolino Esposito, Stefano Favale, Giovanni Licciardello, Luigi Tedesco, Ciro Indolfi
Summary: This study examines the relationship between emotional stress and the occurrence of acute cardiovascular events (ACE) during the UEFA 2020 European Football Championship. The results show a significant increase in the incidence of Takotsubo Syndrome (TTS) during the semifinal and final matches, indicating that positive emotions such as winning can trigger TTS.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Colin Berry, Andrew J. Morrow, Mario Marzilli, Carl J. Pepine
Summary: Ischemic heart disease is a leading global health issue, with major subtypes including coronary heart disease and vasomotor disorders. Men are more likely to have coronary heart disease, while women are more likely to have vasomotor disorders. The diagnostic accuracy of tests differs for different subtypes, emphasizing the need for personalized clinical management.
CARDIOVASCULAR DRUGS AND THERAPY
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Davide Cao, Carl J. Pepine, Roxana Mehran
EUROPEAN HEART JOURNAL
(2022)
Article
Public, Environmental & Occupational Health
Scott M. Vouri, Earl J. Morris, Silken A. Usmani, Rachel Reise, Xinyi Jiang, Carl J. Pepine, Todd M. Manini, Daniel C. Malone, Almut G. Winterstein
Summary: The study evaluated the balance between initiation rates of marker drug before and after initiation of an index drug in the absence of prescribing cascades. The results confirmed the prescription sequence symmetry analysis assumption, as loop diuretic initiation rates before and after DH CCB initiation were similar when not influenced by prescribing cascades.
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2022)
Article
Cardiac & Cardiovascular Systems
Ellen C. Keeley, Han J. Li, Christopher R. Cogle, Eileen M. Handberg, C. Noel Bairey Merz, Carl J. Pepine
Summary: This study found that in female patients with CMD, plasma levels of resolvin D1 and maresin 1 were significantly lower, while levels of docosahexaenoic acid and 18-hydroxyeicosapentaenoic acid were significantly higher. This suggests that insufficient or ineffective production of SPM may play a role in the pathophysiology of CMD.
AMERICAN JOURNAL OF CARDIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Elaine M. Richards, Jing Li, Bruce R. Stevens, Carl J. Pepine, Mohan K. Raizada
Summary: Hypertension is a global health problem with significant impacts on morbidity, mortality, and healthcare resource utilization. The prevalence of hypertension is increasing, affecting nearly 50% of American adults. Despite the availability of multiple antihypertensive drugs and lifestyle modifications, blood pressure control remains inadequate in about 1 in 5 hypertensive individuals. This review discusses the hypothesis of the gut-brain axis in hypertension, highlighting the involvement of gut physiology, gut microbiota, and neuroinflammation. The dysfunction of this axis contributes to hypertension through inflammatory mediators, metabolites, gut bacteria, and altered afferent information, leading to neuroinflammation and dysregulated autonomic nervous system activity. Understanding these mechanisms could potentially lead to more effective treatments for hypertension.
CIRCULATION RESEARCH
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Carl J. Pepine, C. Noel Bairey Merz
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Steven M. M. Smith, Almut G. G. Winterstein, Matthew J. J. Gurka, Marta G. G. Walsh, Shailina Keshwani, Anne M. M. Libby, William R. R. Hogan, Carl J. J. Pepine, Rhonda M. M. Cooper-DeHoff
Summary: This study reveals significant variation in initial antihypertensive prescribing among new users, highlighting a gap between current guideline recommendations and real-world implementation in early hypertension care.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Letter
Cardiac & Cardiovascular Systems
Judy M. Luu, Pankaj Malhotra, Galen Cook-Wiens, Carl J. Pepine, Eileen M. Handberg, Steven E. Reis, Nathaniel Reichek, Vera Bittner, Janet Wei, Sheryl F. Kelsey, Reddy Sailaja Marpuri, George Sopko, C. Noel Bairey Merz
Article
Public, Environmental & Occupational Health
Scott M. Vouri, Earl J. Morris, Marta Walsh, Jessica Agalliu, Alyssa Dempsey, Leonie Hochleitner, Matthew R. Muschett, Stephan Schmidt, Carl J. Pepine, Steven M. Smith
Summary: This study aimed to comprehensively assess prescribing cascades related to statin medications. The results identified potential prescribing cascades, including laxatives, analgesics, and cephalosporins. These findings are important for reducing the occurrence of prescribing cascades.
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2023)
Article
Cardiac & Cardiovascular Systems
Jing Li, Elaine M. Richards, Ramakumar Tummala, Carl J. Pepine, Mohan K. Raizada, Tao Yang
Summary: Hypertension is associated with gut dysbiosis and altered intestinal immunity. Using sorting techniques and gene sequencing, we found significant differences in IgA(+) and IgA(-) bacteria between hypertensive and normotensive rats. We also identified several IgA-coated bacteria that were negatively correlated with various pathways involved in immune response and epithelium development.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
David L. DeRemer, Nam K. Nguyen, Avirup Guha, Faraz S. Ahmad, Rhonda M. Cooper-DeHoff, Carl J. Pepine, Michael G. Fradley, Yan Gong
Summary: This study evaluated the differences in cardiac surveillance among different racial and ethnic groups among survivors of cancer after exposure to anthracycline-based treatment. The study found that African American and Hispanic patients had lower participation rates in cardiac surveillance. These results suggest that healthcare providers need to be aware of social inequities and take measures to ensure recommended cardiac surveillance after anthracycline therapy.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Review
Cardiac & Cardiovascular Systems
Teja Chakrala, Roshni Prakash, Carlos Valdes, Carl J. J. Pepine, Ellen C. C. Keeley
Summary: Coronary microvascular dysfunction is often unrecognized but has significant clinical implications. Circulating biomarkers can provide valuable information for the diagnosis and management of this condition, reflecting key pathological processes like inflammation, endothelial dysfunction, oxidative stress, coagulation, and others.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Robert F. Hamburger, Yasmeen Taha, Mohammed Ruzieh, James R. Clugston, Eileen M. Handberg, Fred Reifsteck, Matthew W. Martinez, Carl J. Pepine, Katherine M. Edenfield
Summary: This study investigated the effects of intense training on cardiac remodeling in American collegiate football players. The findings showed that training was associated with increases in chamber sizes, left atrial size, and aortic root diameter.
CLINICAL CARDIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Grace Hsin-Min Wang, Earl Morris, Scott M. Vouri, Shailina Keshwani, Stephan Schmidt, Carl J. Pepine, Steven M. Smith
Summary: This study aims to identify modifiable statin characteristics associated with lower risk of prescribing cascades. The results show that compared to low-intensity statins, moderate- or high-intensity statins and the choice of individual statin agents are associated with increased risk of prescribing cascades.
Article
Medicine, General & Internal
Yasmeen K. Taha, Jennifer R. Dungan, Michael T. Weaver, Ke Xu, Eileen M. Handberg, Carl J. Pepine, C. Noel Bairey Merz
Summary: Identifying ischemic heart disease (IHD) in women based on symptoms is challenging, as women are more likely to experience non-cardiac symptoms. More than 50% of women with suspected ischemia have no obstructive coronary disease, leading to impaired outcomes during follow-up. A study aimed to identify symptoms that can predict non-obstructive coronary artery disease (INOCA) in women with clinical evidence of coronary ischemia. The study found that age, left side chest pain, chest discomfort, neck pain, and palpitations had a positive relationship with INOCA, while impending doom and pain in the jaw, left or bilateral arm, and right hand were inversely related to INOCA. The best-fit model accurately predicted INOCA based on age and symptom presentation about 72% of the time.
JOURNAL OF CLINICAL MEDICINE
(2023)
