Article
Pharmacology & Pharmacy
Abdullah A. Alamoudi, Osama A. A. Ahmed, Khalid M. El-Say
Summary: This study successfully enhanced the transdermal delivery and bioavailability of avanafil using optimized TPGS-based mixed micelle-loaded film design.
Article
Urology & Nephrology
Taymour Mostafa, Moheiddin F. Alghobary
Summary: Oral phosphodiesterase type 5 inhibitors (PDE5Is) are widely used for the treatment of erectile dysfunction (ED). However, some men abuse these drugs for recreational use to enhance their sexual performance. This literature review reveals a high prevalence of recreational use of oral PDE5Is, highlighting the need for increased awareness and regulation to protect consumers from potential adverse effects.
SEXUAL MEDICINE REVIEWS
(2022)
Article
Medicine, Research & Experimental
Jin Wang, Yan-li Wang, Yao He, Sen Li, You-peng Zhang, Yong-biao Cheng, Jia-lun Guo, Lin Sun, Yu Xin, Yong Tang, Zhao-hui Zhu, Han-qing Zeng
Summary: This study found that a history of drinking, spousal noncooperation, number of fixed sex partners, long duration of ED, and depression could be influencing factors for ED patients' non-response to PDE5 inhibitors.
CURRENT MEDICAL SCIENCE
(2021)
Article
Andrology
Ahmed S. Zaghloul, Abdelrahman M. El-Nashaar, Shady Z. Said, Ihab A. Osman, Taymour Mostafa
Summary: This study evaluated the effectiveness of platelet-rich plasma (PRP) combined with oral tadalafil in diabetic patients with erectile dysfunction (ED) who did not respond to PDE5 inhibitors. The results showed that PRP therapy significantly improved erectile function and erection hardness in these patients. Furthermore, the level of diabetic control was associated with treatment outcomes.
Article
Biochemistry & Molecular Biology
Abhinandan D. Hudwekar, Pankul Kotwal, Mohd. Ishaq Dar, Shilpi Balgotra, Ashish Dogra, Jaspreet Kour, Santosh S. Chobe, Utpal Nandi, Sajad Hussain Syed, Sanghapal D. Sawant
Summary: Continuing our research on sildenafil analogs as inhibitors of PDE5 for erectile dysfunction, we found that modifications at the N-methylpiperazine ring with hydrophobic region followed by hydrogen bond donor or acceptor region have potential. However, previously identified leads had limitations such as poor pharmacokinetic profile, low aqueous solubility, and poor bioavailability. Therefore, we designed, synthesized, and screened a new series of sildenafil based analogs. Compound 18 showed excellent in vitro activity with selectivity towards PDE5 isozyme, as well as excellent in vivo activity and pharmacokinetic profile. The compound also exhibited excellent cyp inhibition and CaCO2 permeability.
CHEMISTRY & BIODIVERSITY
(2023)
Review
Endocrinology & Metabolism
Giuseppe Defeudis, Rossella Mazzilli, Marta Tenuta, Giovanni Rossini, Virginia Zamponi, Soraya Olana, Antongiulio Faggiano, Paolo Pozzilli, Andrea M. Isidori, Daniele Gianfrilli
Summary: This study reviews the definition and prevalence of erectile dysfunction in diabetes mellitus, the impact of diabetes complications and treatment on erectile dysfunction, and current and emerging therapies for erectile dysfunction in patients with diabetes mellitus.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2022)
Article
Physiology
Pamela da Silva Pereira, Dalila Andrade Pereira, Fabiano Beraldi Calmasini, Leonardo O. Reis, Nathan Brinkman, Arthur L. Burnett, Fernando Ferreira Costa, Fabio Henrique Silva
Summary: This study found that in sickle cell disease, decreased haptoglobin levels contribute to abnormal erectile function. Treatment with haptoglobin can improve erectile function by regulating the expression of key proteins involved in the control of penile erection. This suggests that haptoglobin treatment may be an additional strategy to prevent priapism in sickle cell disease.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Chemistry, Applied
Alberto Ongaro, Giuseppe Zagotto, Maurizio Memo, Alessandra Gianoncelli, Giovanni Ribaudo
Summary: In 1998, sildenafil was introduced as the first FDA-approved oral drug for treating erectile dysfunction (ED). Over the past two decades, the development of other synthetic PDE5 inhibitors has been accompanied by the increasing popularity of natural remedies from various chemical classes. In this study, in silico tools were used to evaluate the efficacy of 30 natural compounds claimed to be effective against ED, focusing on pharmacokinetic properties, binding energies for PDE5, and comparison with sildenafil's interaction pattern with PDE.
NATURAL PRODUCT RESEARCH
(2021)
Article
Cell Biology
Michael H. Bourne Jr, Theodore J. Kottom, Deanne M. Hebrink, Malay Choudhury, Edward B. Leof, Andrew H. Limper
Summary: Phosphodiesterase type 5 inhibitor (PDE5-I) vardenafil shows potential in the treatment of idiopathic pulmonary fibrosis (IPF) by suppressing extracellular matrix (ECM) generation and exhibiting significant synergistic effects when used in combination with nintedanib.
Review
Plant Sciences
A. Anand Ganapathy, V. M. Hari Priya, Alaganandam Kumaran
Summary: This paper reviewed 97 medicinal plants with PDE5 inhibitory effect, of which 77 were selected based on their traditional use as aphrodisiacs. Isoflavones and biflavones were identified as the major active constituents responsible for action, while Icariin and Icariside II were found to be the most effective inhibitors from natural sources. Traditional medicines containing extracts of Ginkgo biloba, Kaempferia parviflora, Clerodendrum colebrookianum, Eurycoma longifolia, and Vitis vinifera were also found to inhibit the PDE5 enzyme.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Medicine, Research & Experimental
Hai Wang, Boda Guo, Zhongming Huang, Xin Zhao, Zhigang Ji
Summary: This study found that vardenafil showed significant efficacy in the treatment of erectile dysfunction in men, significantly improving multiple evaluation indicators. However, further research is needed to determine the optimal dosage and course of vardenafil.
ADVANCES IN THERAPY
(2021)
Article
Cardiac & Cardiovascular Systems
Zheng Wang, Yunyun Wang, Jiachao Xiong, Xinxin Gan, Yewei Bao, Aimin Jiang, Ye Zhou, Huangfu Zhao, Yiren Yang, Zhiyong Liu, Demeng Xia, Linhui Wang
Summary: A two-sample Mendelian randomization (MR) study revealed a positive causal link between hypertension and the risk of erectile dysfunction. Various MR methods consistently showed that hypertension is associated with an increased risk of erectile dysfunction. Therefore, more attention should be given to prevent or improve erectile function in the management of hypertension.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Mattia Longoni, Alessandro Bertini, Nicolo Schifano, Emanuele Zaffuto, Paolo Maggio, Rossi Piercarlo, Sara Baldini, Giulio Carcano, Gabriele Antonini, Andrea Salonia, Francesco Montorsi, Federico Deho, Paolo Capogrosso
Summary: Erectile dysfunction (ED) affects a significant percentage of men worldwide, with a strong correlation to aging. Various pharmacological treatments, including oral, injection, and topical/intraurethral therapies, are available for ED. This study provides a comprehensive overview of these treatment options, including available drugs and formulations, their effectiveness, common adverse events, and prescription guidelines. Future directions in ED pharmacotherapy are also discussed.
EXPERT OPINION ON PHARMACOTHERAPY
(2023)
Article
Medicine, General & Internal
Bingbing Zhu, Yangjiu Niu, Lipan Niu, Xijia Zhang, Fengxia Liu
Summary: Sildenafil improves erectile dysfunction by inhibiting inflammation. Intervention with sildenafil can alleviate IL-18-induced inflammation in high-fat diet-induced ED rats, enhancing erectile function through modulation of the NLRP3/caspase-1 pyroptosis pathway.
Article
Polymer Science
Soad A. Mohamed, Remon Roshdy Rofaeil, Hesham Salem, Mahmoud Elrehany, Yahya I. Asiri, Adel Al Fatease, Hamdy Abdelkader
Summary: Oral phosphodiesterase inhibitors have revolutionized the treatment of erectile dysfunction, and topical penile therapy could be a potential replacement for oral medication. This study focuses on developing proniosomal gels for selected members and evaluating their effectiveness on a rodent model. The results show that tadalafil-loaded proniosomal gel has superior skin permeability and improvement in sexual performance compared to the untreated control.
Article
Urology & Nephrology
Eric Chung, Ross Cartmill
Review
Urology & Nephrology
Marianna Zukiwskyj, Padraig Daly, Eric Chung
Review
Urology & Nephrology
Eric Chung, Ross Cartmill
Review
Biotechnology & Applied Microbiology
Eric Chung
EXPERT OPINION ON BIOLOGICAL THERAPY
(2015)
Article
Urology & Nephrology
Eric Chung, Gerald Brock
JOURNAL OF SEXUAL MEDICINE
(2013)
Article
Urology & Nephrology
Eric Chung, Matthew Solomon, Ling DeYoung, Gerald B. Brock
JOURNAL OF SEXUAL MEDICINE
(2013)
Article
Urology & Nephrology
Eric Chung, Ling De Young, Matthew Solomon, Gerald B. Brock
JOURNAL OF SEXUAL MEDICINE
(2013)
Article
Medicine, General & Internal
Eric Chung, Michael Gillman
MEDICAL JOURNAL OF AUSTRALIA
(2014)
Article
Urology & Nephrology
E. Chung, C. T. Van, I. Wilson, R. A. Cartmill
WORLD JOURNAL OF UROLOGY
(2013)
Article
Urology & Nephrology
Eric Chung, Matt Solomon, Ling DeYoung, Gerald B. Brock
WORLD JOURNAL OF UROLOGY
(2014)
Review
Medicine, General & Internal
Matheesha Ranaweera, Eric Chung
WORLD JOURNAL OF CLINICAL CASES
(2014)
Article
Urology & Nephrology
Eric Chung, Sun Yang, Louise White, Simon Wood, David Nicol
KOREAN JOURNAL OF UROLOGY
(2015)
Article
Urology & Nephrology
Jason R. Kovac, Ling DeYoung, Kyle J. Lehmann, Eric Chung, Gerald B. Brock
Meeting Abstract
Urology & Nephrology
Eric Chung, Greg Malone, Ross Cartmill
JOURNAL OF SEXUAL MEDICINE
(2013)
Review
Urology & Nephrology
Eric Chung, Gerald Brock
THERAPEUTIC ADVANCES IN UROLOGY
(2013)