Article
Behavioral Sciences
Jivago Ropke, Talita H. Ferreira-Vieira, Lia P. Iglesias, Laila Asth, Fabiola M. Ribeiro, Fabricio A. Moreira
Summary: The study demonstrated that increasing endocannabinoid levels can protect rats against haloperidol-induced TD through CB1 receptor mediation. High-VCM rats showed increased CB1 receptor expression, which was positively correlated with the number of VCMs.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2021)
Article
Pharmacology & Pharmacy
N. Zareifopoulos, M. Katsaraki, P. Stratos, V. Villiotou, M. Skaltsa, A. Dimitriou, M. Karveli, P. Efthimiou, M. Lagadinou, D. Velissaris
Summary: Akathisia is a troubling side effect of psychiatric drugs, commonly presenting as severe restlessness and purposeless movements, with a potential for chronic persistence even after discontinuation of the causative drug. Various pharmacological interventions, such as propranolol and low-dose mirtazapine, can provide symptomatic relief for akathisia, but management may be challenging in chronic cases. Rotation between different pharmacological strategies may be optimal for treatment in resistant cases.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Pharmacology & Pharmacy
N. Zareifopoulos, M. Skaltsa, A. Dimitriou, M. Karveli, P. Efthimiou, M. Lagadinou, A. Tsigkou, D. Velissaris
Summary: Drugs affecting dopaminergic neurotransmission can have long-term effects that may reverse slowly upon discontinuation. Dopaminergic neurotoxins promote oxidative stress and inhibit mitochondrial function, while stimulants increase intracellular dopamine concentrations and enable dopamine autooxidation. Antipsychotics increase dopamine release and turnover, while dopamine agonists may slow down Parkinson's disease progression but may have behavioral toxicity due to D2 receptor downregulation.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Rohit Singh, Sankha Shubhra Chakrabarti, Upinder Kaur
Summary: The study highlights the atypical manifestation of antipsychotic-associated Rabbit syndrome in the presence of a serotonergic antidepressant. The syndrome is characterized by vertical rhythmic movements of the perioral region, has a late onset, and typically spares the tongue.
DARU-JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Review
Clinical Neurology
Michel Saenz-Farret, Marina A. J. Tijssen, Dawn Eliashiv, Robert S. Fisher, Kapil Sethi, Alfonso Fasano
Summary: The relationship between antiseizure drugs and movement disorders is complex and not adequately reviewed so far. Antiseizure drugs can both treat and induce movement disorders, and this review aims to describe the different effects and proposed mechanisms between 15 movement disorders and 24 antiseizure drugs.
Article
Pharmacology & Pharmacy
Esther S. Kim Bullet, Young-A Heo
Summary: Preventing antipsychotic-induced akathisia involves administering the minimal effective dosage of the medication, avoiding rapid dose escalation, and avoiding polypharmacy; if AIA occurs, adjusting the drug regimen is the first step, with propranolol considered as the first-choice anti-akathisia agent for further intervention.
DRUGS & THERAPY PERSPECTIVES
(2021)
Article
Clinical Neurology
Carmen Gasca-Salas, Sarah Duff-Canning, Melissa J. Armstrong, Paul J. Eslinger, Ruth B. Schneider, Nancy Kennedy, Kelvin L. Chou, Carol Persad, Irene Litvan, Sandra Weintraub, Connie Marras
ACTA NEUROLOGICA SCANDINAVICA
(2020)
Article
Clinical Neurology
Charles W. Lu, Kelvin L. Chou, Parag G. Patil
PARKINSONISM & RELATED DISORDERS
(2020)
Article
Clinical Neurology
Eric Jackowiak, Amanda Cook Maher, Carol Persad, Vikas Kotagal, Kara Wyant, Amelia Heston, Parag G. Patil, Kelvin L. Chou
PARKINSONISM & RELATED DISORDERS
(2020)
Article
Clinical Neurology
Galit Kleiner, Hubert H. Fernandez, Kelvin L. Chou, Alfonso Fasano, Kevin R. Duque, Diana Hengartner, Albie Law, Adam Margolius, Yu-Yan Poon, Michel Saenz Farret, Philip Saleh, Joaquin A. Vizcarra, Glenn T. Stebbins, Alberto J. Espay
Summary: The study validated a final version of a 27-item self-administered NoMoFA questionnaire, capable of effectively capturing both static and fluctuating non-motor symptoms in Parkinson's disease patients. The questionnaire showed good internal consistency, test-retest reliability, and concurrent validity, and underwent item reduction through a Delphi process, resulting in high acceptability.
MOVEMENT DISORDERS
(2021)
Article
Clinical Neurology
Connie Marras, Kelly A. Mills, Shirley Eberly, David Oakes, Kelvin L. Chou, Matthew Halverson, Sotirios A. Parashos, Christopher G. Tarolli, Jin-Shei Lai, Cindy J. Nowinsky, Oksana Suchowersky, Eric S. Farbman, Lisa M. Shulman, Tanya Simuni
Summary: The Neuro-QoL item banks showed limited utility as outcome measures in clinical trials for Parkinson's disease, indicating the need for more sensitive tools.
MOVEMENT DISORDERS
(2021)
Article
Clinical Neurology
Kelvin L. Chou, Justin Martello, Juliana Atem, Matt Elrod, Erin R. Foster, Karen Freshwater, Steven A. Gunzler, Hojoong Kim, Abhimanyu Mahajan, Harini Sarva, Glenn T. Stebbins, Erin Lee, Laurice Yang
Summary: Parkinson disease is the second most common neurodegenerative disorder globally, with increasing number of cases. Both motor and nonmotor symptoms contribute to decreased quality of life and neurologic disability.
Editorial Material
Clinical Neurology
Kelvin L. Chou, David Charles
Article
Clinical Neurology
Asra Askari, Brandon J. Zhu, Xiru Lyu, Kelvin L. Chou, Parag G. Patil
Summary: The study found that STN DBS has differential effects on rigidity in upper and lower extremities in patients with Parkinson's disease. However, there was no significant difference in tremor or bradykinesia between the upper and lower extremities. Even though there were slight differences in the maximal-effect loci for stimulation between the upper and lower extremities, they were not statistically resolved.
PARKINSONISM & RELATED DISORDERS
(2022)
Article
Engineering, Biomedical
Akshay T. Rao, Charles W. Lu, Asra Askari, Karlo A. Malaga, Kelvin L. Chou, Parag G. Patil
Summary: This study derived a data-driven electrophysiological biomarker that predicts clinical DBS location and parameters, and consolidated this information into a quantitative score. The results suggest that biomarker-based trajectory selection and programming may lead to improved motor outcomes for patients undergoing STN DBS surgery.
JOURNAL OF NEURAL ENGINEERING
(2022)
Article
Neurosciences
Marit F. L. Ruitenberg, Vincent Koppelmans, Tina Wu, Bruno B. Averbeck, Kelvin L. Chou, Rachael D. Seidler
Summary: This study aimed to investigate the neural basis of impulsive, risky decision making in Parkinson's disease patients. Using an information-gathering task and fMRI, we found that impulse control disorders in Parkinson's disease are associated with differences in neural processing of risk-related information and outcomes.
EXPERIMENTAL BRAIN RESEARCH
(2022)
Article
Clinical Neurology
Sydney Spagna, Asra Askari, Kara J. Wyant, Laura Zeitlin, Taylor R. Schmitt, Carol C. Persad, Xiru Lyu, Parag G. Patil, Kelvin L. Chou
Summary: This study examined the change in perceived social support in PD patients before and after STN DBS surgery and its impact on clinical outcomes. The results showed that PD patients experienced a decrease in perceived social support after STN DBS, but baseline perceived social support did not affect clinical outcomes. Further research is needed to identify factors that may contribute to this perception of worsened social support.
JOURNAL OF NEURAL TRANSMISSION
(2022)
Article
Clinical Neurology
Kelvin L. Chou, Praveen Dayalu, Robert A. Koeppe, Sid Gilman, C. Chauncey Spears, Roger L. Albin, Vikas Kotagal
Summary: This study compared the serotoninergic innervation in patients with multiple system atrophy (MSA) and Parkinson's disease (PD) using serotonin transporter [C-11]3-amino-4-(2-dimethylaminomethyl-phenylsulfaryl)-benzonitrile positron emission tomography (PET). The results showed that MSA patients exhibited more severe deficits in brainstem and some forebrain subcortical regions compared to PD patients, and these deficits correlated with the severity of motor impairments in MSA.
MOVEMENT DISORDERS
(2022)
Article
Engineering, Biomedical
Akshay T. Rao, Kelvin L. Chou, Parag G. Patil
Summary: This study presents a computer algorithm that can accurately localize intraoperative microelectrode recording (MER) tracks on preoperative magnetic resonance imaging (MRI) in real-time, thereby predicting deviation between the surgical plan and the MER trajectories. The algorithm integrates a random forest model that can distinguish between gray and white matter regions along MER trajectories. It improves the accuracy of electrode position estimation during subthalamic nucleus deep brain stimulation (STN DBS) surgery.
JOURNAL OF NEURAL ENGINEERING
(2023)
Article
Clinical Neurology
Karen J. Kluin, James M. Mossner, Joseph T. Costello, Kelvin L. Chou, Parag G. Patil
Summary: This study investigated the effects of STN DBS on motor speech in PD patients and the potential of intraoperative testing to predict outcomes. Intraoperative motor speech testing was found to strongly predict postoperative outcomes, and distinct stimulation sites were identified for motor speech deterioration and motor improvement as measured by MDS-UPDRS.
JOURNAL OF NEUROSURGERY
(2021)
Article
Neuroimaging
Karlo A. Malaga, Joseph T. Costello, Kelvin L. Chou, Parag G. Patil
Summary: The optimal regions for STN DBS treatment in Parkinson's disease were found to be located medial, posterior, and dorsal to the STN centroid, extending towards the caudal zona incerta (cZI). Therapeutic stimulation spread notably more in the dorsal and posterior directions, with significant linear relationships between the amount of dorsal and posterior stimulation and motor improvement. The variability in STN anatomy, active contact position, and VTA location among patients highlights the importance of individualized modeling techniques for optimizing DBS outcomes.
NEUROIMAGE-CLINICAL
(2021)
