Review
Rheumatology
Mayara Santos, Flavia L. Gabani, Selma M. de Andrade, Bruno Bizzozero-Peroni, Vicente Martinez-Vizcaino, Alberto D. Gonzalez, Arthur Eumann Mesas
Summary: This systematic review and meta-analysis examines the bidirectional associations between sleep-related problems (SRP) and chronic musculoskeletal pain (CMP) in adults. The findings show that individuals with SRP at baseline have a higher incidence and persistence of CMP, while individuals with CMP at baseline have a higher incidence of SRP.
Article
Orthopedics
Keijiro Kanno, Miyako Narita, Yuya Kawarai, Shigeo Hagiwara, Satoshi Yoh, Junichi Nakamura, Sumihisa Orita, Kazuhide Inage, Takane Suzuki, Seiji Ohtori
Summary: Tramadol administration alleviated mechanical hyperalgesia induced by MIA injection into the rat hip joint, and significantly suppressed CGRP expression in DRG. However, the progression of OA changes was significantly exacerbated in the MIA + Tramadol group compared to the MIA + Vehicle group.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Rafael Tamborena Malheiros, Gabriela Escalante Brites, Elizandra Gomes Schmitt, Laura Smolski dos Santos, Genifer Erminda Schreiner, Silvia Muller de Moura Sarmento, Itamar Luis Goncalves, Morgana Duarte da Silva, Vanusa Manfredini
Summary: This study aimed to evaluate whether obesity associated with osteoarthritis (OA) may increase inflammation and pain. The results showed that obesity altered the nociceptive profile, increased systemic inflammatory cytokines, and reduced anti-inflammatory cytokines. When obesity occurred together with OA, the inflammatory progression was intensified, leading to increased pain scores.
Review
Medicine, General & Internal
Charlotte C. Gupta, Madeline Sprajcer, Colleen Johnston-Devin, Sally A. Ferguson
Summary: This scoping review examines the state of the existing literature on sleep hygiene strategies in individuals with chronic pain. Results indicate that out of 30 articles investigating sleep hygiene strategies in this population, six strategies (education, exercise, limiting alcohol use, limiting tobacco use, prebed state, and sleep environment) were found to improve sleep. However, the timing of these strategies was often not reported, limiting their effectiveness as presleep strategies.
Article
Psychology, Multidisciplinary
Zoe Zambelli, Elizabeth J. Halstead, Antonio R. Fidalgo, Dagmara Dimitriou
Summary: Individuals with chronic pain often experience co-existing sleep problems and depression-related states. Chronic pain, sleep problems, and depression interrelate, and have been shown to exacerbate one another, which negatively impacts quality of life. The study found that sleep quality may moderate the relationship between pain interference and depression among individuals with chronic pain.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Biology
Marcel Simis, Kevin Pacheco-Barrios, Karen Vasquez-Avila, Ingrid Rebello-Sanchez, Joao Parente, Luis Castelo-Branco, Anna Marduy, Paulo S. de Melo, Marta Imamura, Linamara Battistella, Felipe Fregni
Summary: This study aimed to assess the factors predicting a dysfunctional conditioned pain modulation (CPM) in chronic knee OA. Linear and logistic multivariate regression models were used to analyze the relationship between demographics, clinical, and neurophysiological factors and CPM. The study found a significant negative association between WOMAC pain scores and CPM, as well as associations with balance and brain frequency changes.
Article
Medicine, General & Internal
David C. Currow, Sungwon Chang, Diana Ferreira, Danny J. Eckert, David Gonzalez-Chica, Nigel Stocks, Magnus Per Ekstrom
Summary: The study aimed to explore the relationship between chronic breathlessness and sleep problems independently of diagnoses and health service contact by surveying a large, representative sample of the general population. The results showed a strong association between chronic breathlessness and sleep problems, with individuals with sleep problems more likely to have breathlessness, be older with higher BMI, and females more likely to have current sleep problems. Adjusted odds ratios indicated that respondents with chronic breathlessness had a higher likelihood of both past and current sleep problems. Future work will focus on understanding the causal relationship between the two conditions.
Article
Chemistry, Medicinal
Szabolcs Koncz, Noemi Papp, Noemi Menczelesz, Dora Pothorszki, Gyorgy Bagdy
Summary: Tramadol, a centrally acting opioid analgesic compound, has inhibitory effects on serotonin and noradrenaline reuptake, 5-HT2, and NMDA receptors. Studies on its effects on sleep architecture and qEEG in Wistar rats showed dose-dependent reduction in REM sleep time, wake-promoting effects at lower doses, and increased gamma power during non-REM sleep. These results suggest potential antidepressant-like properties of tramadol.
Article
Public, Environmental & Occupational Health
Erica A. Voss, Saberi Rana Ali, Arun Singh, Peter R. Rijnbeek, Martijn J. Schuemie, Daniel Fife
Summary: This observational study compared the risk of hip fracture in new users of tramadol or codeine, finding no statistically significant difference between the two drugs in terms of hip fracture risk. Multiple databases and analytical methods were used to reach this conclusion, indicating that both tramadol and codeine have similar outcomes when it comes to the risk of hip fractures in older adults.
Review
Psychiatry
Lan Duo, Xintong Yu, Ruihan Hu, Xiping Duan, Jia Zhou, Ke Wang
Summary: Chronic pain and sleep disorders are common problems that seriously affect patients' quality of life, but there is still a lack of comprehensive understanding of this comorbidity. This review article summarizes the prevalence of comorbid sleep disorders in chronic pain patients, sleep detection methods, sleep characterization in chronic pain, the impact of sleep disorders on chronic pain, and current therapies. The neurochemical mechanisms underlying the comorbidity of chronic pain with sleep disorders are still limited.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Anesthesiology
Teemu Miettinen, Jaana Sverloff, Olli-Pekka Lappalainen, Steven J. Linton, Kirsi Sipila, Eija Kalso
Summary: Chronic pain and sleep problems often occur together. This study found that pain patients with sleep problems were more likely to have other health conditions and childhood adversities, and used more sleep and pain medications.
Article
Neurosciences
Joana Barroso, Kenta Wakaizumi, Ana Mafalda Reis, Marwan Baliki, Thomas J. Schnitzer, Vasco Galhardo, Apkar Vania Apkarian
Summary: The study found that in patients with osteoarthritis, the brain network architecture reorganizes at both global and local levels. Network connectivity related to pain intensity in OA is dissociated from major hub disruptions. This challenges the extent of dependence of OA pain on nociceptive signaling.
HUMAN BRAIN MAPPING
(2021)
Review
Pharmacology & Pharmacy
Vipin Arora, James N. Campbell, Man-Kyo Chung
Summary: Capsaicin, the pungent ingredient in chili peppers, can cause intense burning pain in humans, but it has also been used as an analgesic for chronic pain conditions. The analgesic effects of capsaicin depend on concentration, with low concentrations inducing short-term defunctionalization and high concentrations leading to long-term defunctionalization.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Medicine, General & Internal
Junqing Xie, Victoria Y. Strauss, Daniel Martinez-Laguna, Cristina Carbonell-Abella, Adolfo Diez-Perez, Xavier Nogues, Gary S. Collins, Sara Khalid, Antonella Delmestri, Aleksandra Turkiewicz, Martin Englund, Mina Tadrous, Carlen Reyes, Daniel Prieto-Alhambra
Summary: In this study, new prescription dispensation of tramadol was significantly associated with a higher risk of all-cause mortality, cardiovascular events, and fractures compared to codeine, with no significant differences in the risk of other adverse outcomes. The findings emphasize the importance of cautious interpretation due to potential residual confounding.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Anesthesiology
Stephen Bruehl, Ginger Milne, Jonathan Schildcrout, Yaping Shi, Sara Anderson, Andrew Shinar, Gregory Polkowski, Puneet Mishra, Frederic T. Billings
Summary: This study examined the relationship between the dysfunctional chronic pain (Dysfunctional CP) phenotype and elevated oxidative stress (OS). The results showed that higher levels of OS were associated with more severe pain, widespread pain, greater depressive symptoms and pain catastrophizing, higher pain interference, and lower function.