5-HT2 ligands in the treatment of anxiety and depression

Antinociceptive effects of fluoxetine in a mouse model of anxiety/depression

(2012) Guillaume Hache et al.   NEUROREPORT

Estimate of deaths due to valvular insufficiency attributable to the use of benfluorex in France

(2012) Agnès Fournier et al.   PHARMACOEPIDEMIOLOGY AND DRUG SAFETY

Lorcaserin: An investigational serotonin 2C agonist for weight loss

(2011) K. M. Hurren et al.   AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY

Animal Models of Neuropsychiatric Disorders

(2011) A.B.P. Fernando et al.   Annual Review of Clinical Psychology

Neurogenesis and affective disorders

(2011) Benjamin A. Samuels et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Glial cells in adult neurogenesis

(2011) Joachim Morrens et al.   GLIA

Neurobiological bases and clinical aspects of the use of aripiprazole in treatment-resistant major depressive disorder

(2011) Pierre Blier et al.   JOURNAL OF AFFECTIVE DISORDERS

Serotonin-1A Autoreceptors Are Necessary and Sufficient for the Normal Formation of Circuits Underlying Innate Anxiety

(2011) J. W. Richardson-Jones et al.   JOURNAL OF NEUROSCIENCE

Deletion of ERK1 and ERK2 in the CNS Causes Cortical Abnormalities and Neonatal Lethality: Erk1 Deficiency Enhances the Impairment of Neurogenesis in Erk2-Deficient Mice

(2011) Y. Satoh et al.   JOURNAL OF NEUROSCIENCE

Integrated behavioral z-scoring increases the sensitivity and reliability of behavioral phenotyping in mice: Relevance to emotionality and sex

(2011) Jean-Philippe Guilloux et al.   JOURNAL OF NEUROSCIENCE METHODS

Mécanismes des effets comportementaux de type anxiolytique/ antidépresseur de la fluoxétine (Prozac®)

(2011) Quentin Rainer et al.   M S-MEDECINE SCIENCES

5-HT2B receptors are required for serotonin-selective antidepressant actions

(2011) S L Diaz et al.   MOLECULAR PSYCHIATRY

Implication of 5-HT2B receptors in the serotonin syndrome

(2011) Silvina Laura Diaz et al.   NEUROPHARMACOLOGY

Anxiolytic effects of 5-HT1A receptors and anxiogenic effects of 5-HT2C receptors in the amygdala of mice

(2011) Qian Li et al.   NEUROPHARMACOLOGY

5-HT2C Receptors Localize to Dopamine and GABA Neurons in the Rat Mesoaccumbens Pathway

(2011) Marcy J. Bubar et al.   PLoS One

Fluoxetine regulates the expression of neurotrophic/growth factors and glucose metabolism in astrocytes

(2011) Igor Allaman et al.   PSYCHOPHARMACOLOGY

Therapeutic Potential of 5-HT2CReceptor Ligands

(2011) Nanna H. Jensen et al.   TheScientificWorldJOURNAL

Altered 5-HT2C receptor agonist-induced responses and 5-HT2C receptor RNA editing in the amygdala of serotonin transporter knockout mice

(2011) Pablo R Moya et al.   BMC Pharmacology & Toxicology

Arylpiperazine-containing pyrimidine 4-carboxamide derivatives targeting serotonin 5-HT2A, 5-HT2C, and the serotonin transporter as a potential antidepressant

(2010) Jong Yup Kim et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Arylpiperazine-containing pyrrole 3-carboxamide derivatives targeting serotonin 5-HT2A, 5-HT2C, and the serotonin transporter as a potential antidepressant

(2010) Suk Youn Kang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Role of Serotonin in Central Dopamine Dysfunction

(2010) Giuseppe Di Giovanni et al.   CNS Neuroscience & Therapeutics

5-HT2A and 5-HT2C receptor stimulation are differentially involved in the cortical dopamine efflux—Studied in 5-HT2A and 5-HT2C genetic mutant mice

(2010) Mei Huang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Sex differences in the activity of signalling pathways and expression of G-protein-coupled receptor kinases in the neonatal ventral hippocampal lesion model of schizophrenia

(2010) Evgeny Bychkov et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Dopamine release induced by atypical antipsychotics in prefrontal cortex requires 5-HT1A receptors but not 5-HT2A receptors

(2010) Analía Bortolozzi et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Simultaneous projections from prefrontal cortex to dopaminergic and serotonergic nuclei

(2010) Pablo Vázquez-Borsetti et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Strain-dependent serotonin neuron feedback control: role of serotonin2C receptors

(2010) Eleonora Calcagno et al.   JOURNAL OF NEUROCHEMISTRY

5-HT2C receptor activation prevents stress-induced enhancement of brain 5-HT turnover and extracellular levels in the mouse brain: modulation by chronic paroxetine treatment

(2010) Raymond Mongeau et al.   JOURNAL OF NEUROCHEMISTRY

Efficacy markers in depression

(2010) Catherine J Harmer et al.   JOURNAL OF PSYCHOPHARMACOLOGY

5-HT1A Autoreceptor Levels Determine Vulnerability to Stress and Response to Antidepressants

(2010) Jesse W. Richardson-Jones et al.   NEURON

5-HT2B receptors are expressed on astrocytes from brain and in culture and are a chronic target for all five conventional ‘serotonin-specific reuptake inhibitors’

(2010) Shiquen Zhang et al.   Neuron Glia Biology

Effects of serotonin (5-HT)2 receptor ligands on depression-like behavior during nicotine withdrawal

(2010) Magdalena Zaniewska et al.   NEUROPHARMACOLOGY

Deconstructing Antiobesity Compound Action: Requirement of Serotonin 5-HT2B Receptors for Dexfenfluramine Anorectic Effects

(2010) Sophie M Banas et al.   NEUROPSYCHOPHARMACOLOGY

The effectiveness of multi-target agents in schizophrenia and mood disorders: Relevance of receptor signature to clinical action

(2010) Erik H.F. Wong et al.   PHARMACOLOGY & THERAPEUTICS

Combination of Antidepressant Medications From Treatment Initiation for Major Depressive Disorder: A Double-Blind Randomized Study

(2009) Pierre Blier et al.   AMERICAN JOURNAL OF PSYCHIATRY

Brain structures implicated in the four-plate test in naïve and experienced Swiss mice using injection of diazepam and the 5-HT2A agonist DOI

(2009) Benoit Petit-Demoulière et al.   BEHAVIOURAL BRAIN RESEARCH

5-Hydroxytryptamine 2C Receptors in the Basolateral Amygdala Are Involved in the Expression of Anxiety After Uncontrollable Traumatic Stress

(2009) John P. Christianson et al.   BIOLOGICAL PSYCHIATRY

Further pharmacological characterization of 5-HT2C receptor agonist-induced inhibition of 5-HT neuronal activity in the dorsal raphe nucleus in vivo

(2009) P Quérée et al.   BRITISH JOURNAL OF PHARMACOLOGY

Prospect of a Dopamine Contribution in the Next Generation of Antidepressant Drugs: The Triple Reuptake Inhibitors

(2009) Bruno Guiard et al.   CURRENT DRUG TARGETS

Enhancement of cortical extracellular 5-HT by 5-HT1A and 5-HT2C receptor blockade restores the antidepressant-like effect of citalopram in non-responder mice

(2009) Eleonora Calcagno et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Altered levels of extracellular signal-regulated kinase signaling proteins in postmortem frontal cortex of individuals with mood disorders and schizophrenia

(2009) Peixiong Yuan et al.   JOURNAL OF AFFECTIVE DISORDERS

Early-life stress and antidepressant treatment involve synaptic signaling and Erk kinases in a gene-environment model of depression

(2009) Laura Musazzi et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Comparative efficacy and acceptability of 12 new-generation antidepressants: a multiple-treatments meta-analysis

(2009) Andrea Cipriani et al.   LANCET

Neurogenesis-Dependent and -Independent Effects of Fluoxetine in an Animal Model of Anxiety/Depression

(2009) Denis J. David et al.   NEURON

Relevance of dorsal raphe nucleus firing in serotonin 5-HT2C receptor blockade-induced augmentation of SSRIs effects

(2009) Florence Sotty et al.   NEUROPHARMACOLOGY

Mechanisms Contributing to the Phase-Dependent Regulation of Neurogenesis by the Novel Antidepressant, Agomelatine, in the Adult Rat Hippocampus

(2009) Amélie Soumier et al.   NEUROPSYCHOPHARMACOLOGY

A novel 5-HT2A receptor antagonist exhibits antidepressant-like effects in a battery of rodent behavioural assays: Approaching early-onset antidepressants

(2009) Dilip Kumar Pandey et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Implication of the 5-HT2A and 5-HT2C (but not 5HT1A) receptors located within the periaqueductal gray in the elevated plus-maze test–retest paradigm in mice

(2009) K.S. Gomes et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Chronic treatment of astrocytes with therapeutically relevant fluoxetine concentrations enhances cPLA2 expression secondary to 5-HT2B-induced, transactivation-mediated ERK1/2 phosphorylation

(2009) Baoman Li et al.   PSYCHOPHARMACOLOGY

Genetic variation in the serotonin 2A receptor and suicidal ideation in a sample of 270 Irish high-density schizophrenia families

(2008) Ayman H. Fanous et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Glial Loss in the Prefrontal Cortex Is Sufficient to Induce Depressive-like Behaviors

(2008) Mounira Banasr et al.   BIOLOGICAL PSYCHIATRY

Pyramidal Neurons in Rat Prefrontal Cortex Projecting to Ventral Tegmental Area and Dorsal Raphe Nucleus Express 5-HT2A Receptors

(2008) P. Vazquez-Borsetti et al.   CEREBRAL CORTEX

Functional interactions between dopamine, serotonin and norepinephrine neurons: an in-vivo electrophysiological study in rats with monoaminergic lesions

(2008) Bruno P. Guiard et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Serotonin (5-HT) induces glial cell line-derived neurotrophic factor (GDNF) mRNA expression via the transactivation of fibroblast growth factor receptor 2 (FGFR2) in rat C6 glioma cells

(2008) Mami Tsuchioka et al.   JOURNAL OF NEUROCHEMISTRY

CNTF: A Putative Link between Dopamine D2 Receptors and Neurogenesis

(2008) M. Mori et al.   JOURNAL OF NEUROSCIENCE

Serotonin 5-HT2B Receptors Are Required for 3,4-Methylenedioxymethamphetamine-Induced Hyperlocomotion and 5-HT Release In Vivo and In Vitro

(2008) S. Doly et al.   JOURNAL OF NEUROSCIENCE

Serotonin receptor HTR1A and HTR2C variants and personality traits in suicide attempters and controls

(2008) Alessandro Serretti et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Glial pathology in an animal model of depression: reversal of stress-induced cellular, metabolic and behavioral deficits by the glutamate-modulating drug riluzole

(2008) M Banasr et al.   MOLECULAR PSYCHIATRY

Fluoxetine increases the activity of the ERK-CREB signal system and alleviates the depressive-like behavior in rats exposed to chronic forced swim stress

(2008) Xiaoli Qi et al.   NEUROBIOLOGY OF DISEASE

Elevated 5-HT 2A receptors in postmortem prefrontal cortex in major depression is associated with reduced activity of protein kinase A

(2008) R.C. Shelton et al.   NEUROSCIENCE

5-HT2A/2C receptor blockade regulates progenitor cell proliferation in the adult rat hippocampus

(2008) Shanker Jha et al.   NEUROSCIENCE LETTERS

The effects of the selective 5-HT2C receptor antagonist SB 242084 on learned helplessness in male Fischer 344 rats

(2008) Paul V. Strong et al.   PSYCHOPHARMACOLOGY

Anxiety-like behaviors produced by acute fluoxetine administration in male Fischer 344 rats are prevented by prior exercise

(2008) Benjamin N. Greenwood et al.   PSYCHOPHARMACOLOGY

S32006, a novel 5-HT2C receptor antagonist displaying broad-based antidepressant and anxiolytic properties in rodent models

(2008) Anne Dekeyne et al.   PSYCHOPHARMACOLOGY

Fluoxetine-mediated 5-HT2B receptor stimulation in astrocytes causes EGF receptor transactivation and ERK phosphorylation

(2008) Baoman Li et al.   PSYCHOPHARMACOLOGY

Regionally Specific Regulation of ERK MAP Kinase in a Model of Antidepressant-Sensitive Chronic Depression

(2007) Shannon L. Gourley et al.   BIOLOGICAL PSYCHIATRY

Perspectives on genetic animal models of serotonin toxicity

(2007) Allan V. Kalueff et al.   NEUROCHEMISTRY INTERNATIONAL

Effects of Acute and Chronic Administration of the Serotonin1A Agonist Buspirone on Serotonin Synthesis in the Rat Brain

(2003) Hidehiko Okazawa et al.   JOURNAL OF NEUROCHEMISTRY