Terpenoids: natural products for cancer therapy

The Effects of Cantharidin and Cantharidin Derivates on Tumour Cells

(2012) Dongwu Liu et al.   Anti-Cancer Agents in Medicinal Chemistry

Protein Phosphatase 2A as a Potential Target for Anticancer Therapy

(2012) Peter Kalev et al.   Anti-Cancer Agents in Medicinal Chemistry

Lycopene inhibits angiogenesis both in vitro and in vivo by inhibiting MMP-2/uPA system through VEGFR2-mediated PI3K-Akt and ERK/p38 signaling pathways

(2012) Man-Ling Chen et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Cancer Chemoprevention by Carotenoids

(2012) Takuji Tanaka et al.   MOLECULES

Carotenoids reverse multidrug resistance in cancer cells by interfering with ABC-transporters

(2012) Safaa Yehia Eid et al.   PHYTOMEDICINE

Histone deacetylase inhibitor valproic acid sensitizes B16F10 melanoma cells to cucurbitacin B treatment

(2011) Dongyun Ouyang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Reactive oxygen species contribute to oridonin-induced apoptosis and autophagy in human cervical carcinoma HeLa cells

(2011) Ya-hong Zhang et al.   ACTA PHARMACOLOGICA SINICA

Vinflunine

(2011) Luis Miguel Anton Aparicio et al.   ANTI-CANCER DRUGS

Cucurbitacin IIa: a novel class of anti-cancer drug inducing non-reversible actin aggregation and inhibiting survivin independent of JAK2/STAT3 phosphorylation

(2011) C Boykin et al.   BRITISH JOURNAL OF CANCER

Lycopene inhibits angiogenesis in human umbilical vein endothelial cells and rat aortic rings

(2011) Simone Elgass et al.   BRITISH JOURNAL OF NUTRITION

Cucurbitacin I inhibits tumorigenic ability and enhances radiochemosensitivity in nonsmall cell lung cancer-derived CD133-positive cells

(2011) Han-Shui Hsu et al.   CANCER

PP2A inhibitors induce apoptosis in pancreatic cancer cell line PANC-1 through persistent phosphorylation of IKKα and sustained activation of the NF-κB pathway

(2011) Wei Li et al.   CANCER LETTERS

Anti-angiogenic effect of Tanshinone IIA involves inhibition of matrix invasion and modification of MMP-2/TIMP-2 secretion in vascular endothelial cells

(2011) Ming-Yen Tsai et al.   CANCER LETTERS

Andrographolide and its analogues: versatile bioactive molecules for combating inflammation and cancer

(2011) Jonathan Chee Woei Lim et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

The State of the Art in Anti-Malarial Drug Discovery and Development

(2011) Jeremy N. Burrows et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Anti-inflammatory activities of cucurbitacin E isolated from Citrullus lanatus var. citroides: Role of reactive nitrogen species and cyclooxygenase enzyme inhibition

(2011) Siddig Ibrahim Abdelwahab et al.   FITOTERAPIA

Antioxidant and anti-proliferative properties of lycopene

(2011) Mareike Kelkel et al.   FREE RADICAL RESEARCH

Triptolide and its expanding multiple pharmacological functions

(2011) Qiuyan Liu   INTERNATIONAL IMMUNOPHARMACOLOGY

Andrographolide Inhibits Oral Squamous Cell Carcinogenesis through NF-κB Inactivation

(2011) L.-J. Wang et al.   JOURNAL OF DENTAL RESEARCH

Tanshinone IIA activates calcium-dependent apoptosis signaling pathway in human hepatoma cells

(2011) Zhi-Kai Dai et al.   Journal of Natural Medicines

β-Carotene and Lutein Inhibit Hydrogen Peroxide-Induced Activation of NF-κB and IL-8 Expression in Gastric Epithelial AGS Cells

(2011) Youngha KIM et al.   JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY

Characterization of dihydroartemisinin-resistant colon carcinoma HCT116/R cell line

(2011) Jin-Jian Lu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

XPB, a subunit of TFIIH, is a target of the natural product triptolide

(2011) Denis V Titov et al.   Nature Chemical Biology

Artemisinin: the gifts from traditional Chinese medicine not only for malaria control but also for schistosomiasis control

(2011) Rong Liu et al.   PARASITOLOGY RESEARCH

Inhibition of tumor progression by naturally occurring terpenoids

(2011) Girija Kuttan et al.   PHARMACEUTICAL BIOLOGY

Triptolide (TPL) Inhibits Global Transcription by Inducing Proteasome-Dependent Degradation of RNA Polymerase II (Pol II)

(2011) Ying Wang et al.   PLoS One

Cucurbitacin: Ancient Compound Shedding New Light on Cancer Treatment

(2011) Dhong Hyun Lee et al.   TheScientificWorldJOURNAL

Anti-cancer natural products isolated from chinese medicinal herbs

(2011) Wen Tan et al.   Chinese Medicine

Celastrol Attenuates Hypertension-Induced Inflammation and Oxidative Stress in Vascular Smooth Muscle Cells via Induction of Heme Oxygenase-1

(2010) X. Yu et al.   AMERICAN JOURNAL OF HYPERTENSION

Inactivation of PI3k/Akt signaling pathway and activation of caspase-3 are involved in tanshinone I-induced apoptosis in myeloid leukemia cells in vitro

(2010) Jia-Jun Liu et al.   ANNALS OF HEMATOLOGY

The induction of G2/M cell-cycle arrest and apoptosis by cucurbitacin E is associated with increased phosphorylation of eIF2α in leukemia cells

(2010) Yanchun Li et al.   ANTI-CANCER DRUGS

Celastrol suppresses IFN-gamma-induced ICAM-1 expression and subsequent monocyte adhesiveness via the induction of heme oxygenase-1 in the HaCaT cells

(2010) Won Yong Seo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Celastrol: Molecular targets of Thunder God Vine

(2010) Antero Salminen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dihydroartemisinin accelerates c-MYC oncoprotein degradation and induces apoptosis in c-MYC-overexpressing tumor cells

(2010) Jin-Jian Lu et al.   BIOCHEMICAL PHARMACOLOGY

Suppression of PMA-induced tumor cell invasion by dihydroartemisinin via inhibition of PKCα/Raf/MAPKs and NF-κB/AP-1-dependent mechanisms

(2010) Yong Pil Hwang et al.   BIOCHEMICAL PHARMACOLOGY

Tanshinone IIA Induces Mitochondria Dependent Apoptosis in Prostate Cancer Cells in Association with an Inhibition of Phosphoinositide 3-Kinase/AKT Pathway

(2010) Suk-Hyun Won et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Pachymic acid impairs breast cancer cell invasion by suppressing nuclear factor-κB-dependent matrix metalloproteinase-9 expression

(2010) Hui Ling et al.   BREAST CANCER RESEARCH AND TREATMENT

Cucurbitacin B, a novel in vivo potentiator of gemcitabine with low toxicity in the treatment of pancreatic cancer

(2010) Gabriela B Iwanski et al.   BRITISH JOURNAL OF PHARMACOLOGY

Dihydroartemisinin induces apoptosis in HL-60 leukemia cells dependent of iron and p38 mitogen-activated protein kinase activation but independent of reactive oxygen species

(2010) Jin-Jian Lu et al.   CANCER BIOLOGY & THERAPY

Dihydroartemisinin upregulates death receptor 5 expression and cooperates with TRAIL to induce apoptosis in human prostate cancer cells

(2010) Qin He et al.   CANCER BIOLOGY & THERAPY

Cryptotanshinone sensitizes DU145 prostate cancer cells to Fas(APO1/CD95)-mediated apoptosis through Bcl-2 and MAPK regulation

(2010) In-Ja Park et al.   CANCER LETTERS

Dihydroartemisinin inactivates NF-κB and potentiates the anti-tumor effect of gemcitabine on pancreatic cancer both in vitro and in vivo

(2010) Shuang-Jia Wang et al.   CANCER LETTERS

Cucurbitacin B induces apoptosis and S phase cell cycle arrest in BEL-7402 human hepatocellular carcinoma cells and is effective via oral administration

(2010) Kin Tak Chan et al.   CANCER LETTERS

Celastrol Suppresses Angiogenesis-Mediated Tumor Growth through Inhibition of AKT/Mammalian Target of Rapamycin Pathway

(2010) X. Pang et al.   CANCER RESEARCH

Cantharidin, a potent and selective PP2A inhibitor, induces an oxidative stress-independent growth inhibition of pancreatic cancer cells through G2/M cell-cycle arrest and apoptosis

(2010) Wei Li et al.   CANCER SCIENCE

Factors determining sensitivity or resistance of tumor cell lines towards artesunate

(2010) Serkan Sertel et al.   CHEMICO-BIOLOGICAL INTERACTIONS

STAT3α Is Oncogenic for Endometrial Carcinoma Cells and Mediates the Oncogenic Effects of Autocrine Human Growth Hormone

(2010) Jian-Zhong Tang et al.   ENDOCRINOLOGY

First evidence that the antimalarial drug artesunate inhibits invasion and in vivo metastasis in lung cancer by targeting essential extracellular proteases

(2010) Suhail Ahmed Kabeer Rasheed et al.   INTERNATIONAL JOURNAL OF CANCER

C/EBPβ and CHOP participate in Tanshinone IIA-induced differentiation and apoptosis of acute promyelocytic leukemia cells in vitro

(2010) Kaiji Zhang et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

The anti-cancer activity of dihydroartemisinin is associated with induction of iron-dependent endoplasmic reticulum stress in colorectal carcinoma HCT116 cells

(2010) Jin-Jian Lu et al.   INVESTIGATIONAL NEW DRUGS

Downregulation of AP-1 gene expression is an initial event in the oridonin-mediated inhibition of colorectal cancer: Studies in vitro and in vivo

(2010) Heiying Jin et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Cytotoxic Effects of Tanshinones fromSalvia miltiorrhizaon Doxorubicin-Resistant Human Liver Cancer Cells

(2010) Wayne Y. W. Lee et al.   JOURNAL OF NATURAL PRODUCTS

Celastrol Acts as a Potent Antimetastatic Agent Targeting  1 Integrin and Inhibiting Cell-Extracellular Matrix Adhesion, in Part via the p38 Mitogen-Activated Protein Kinase Pathway

(2010) H. Zhu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Increased accumulation of hypoxia-inducible factor-1α with reduced transcriptional activity mediates the antitumor effect of triptolide

(2010) Zhao-Li Zhou et al.   Molecular Cancer

HSP90 inhibitor, celastrol, arrests human monocytic leukemia cell U937 at G0/G1 in thiol-containing agents reversible way

(2010) Bin Peng et al.   Molecular Cancer

Cucurbitacin I Suppressed Stem-Like Property and Enhanced Radiation-Induced Apoptosis in Head and Neck Squamous Carcinoma-Derived CD44+ALDH1+ Cells

(2010) Y.-W. Chen et al.   MOLECULAR CANCER THERAPEUTICS

Dihydroartemisinin Induces Apoptosis by a Bak-Dependent Intrinsic Pathway

(2010) R. Handrick et al.   MOLECULAR CANCER THERAPEUTICS

Alisol B, a Novel Inhibitor of the Sarcoplasmic/Endoplasmic Reticulum Ca2+ ATPase Pump, Induces Autophagy, Endoplasmic Reticulum Stress, and Apoptosis

(2010) B. Y. K. Law et al.   MOLECULAR CANCER THERAPEUTICS

Inhibition of Constitutive Activation of STAT3 by Curcurbitacin-I (JSI-124) Sensitized Human B-Leukemia Cells to Apoptosis

(2010) G. Ishdorj et al.   MOLECULAR CANCER THERAPEUTICS

Pseudolaric acids: isolation, bioactivity and synthetic studies

(2010) Pauline Chiu et al.   NATURAL PRODUCT REPORTS

Inhibition of Pancreatic Cancer Cell Growth by Cucurbitacin B Through Modulation of Signal Transducer and Activator of Transcription 3 Signaling

(2010) Meixia Zhang et al.   PANCREAS

Cucurbitacin I Inhibits Cell Motility by Indirectly Interfering with Actin Dynamics

(2010) David A. Knecht et al.   PLoS One

Inhibitory effects of tanshinone II-A on invasion and metastasis of human colon carcinoma cells

(2009) Yun-feng Shan et al.   ACTA PHARMACOLOGICA SINICA

Triterpenoids as new promising anticancer drugs

(2009) Alessia Petronelli et al.   ANTI-CANCER DRUGS

Dihydroartemisinin inhibits growth of pancreatic cancer cells in vitro and in vivo

(2009) Hua Chen et al.   ANTI-CANCER DRUGS

NF-κb facilitates oridonin-induced apoptosis and autophagy in HT1080 cells through a p53-mediated pathway

(2009) Yahong Zhang et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Molecular mechanisms of oridonin-induced apoptosis and autophagy in murine fibrosarcoma L929 cells

(2009) Yan Cheng et al.   Autophagy

Anti-cancer effects of artesunate in a panel of chemoresistant neuroblastoma cell lines

(2009) Martin Michaelis et al.   BIOCHEMICAL PHARMACOLOGY

Artesunate induces oncosis-like cell death in vitro and has antitumor activity against pancreatic cancer xenografts in vivo

(2009) Ji-Hui Du et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Reactive oxygen species-mediated kinase activation by dihydrotanshinone in tanshinones-induced apoptosis in HepG2 cells

(2009) Wayne Y.W. Lee et al.   CANCER LETTERS

Cucurbitacin B Induces Apoptosis by Inhibition of the JAK/STAT Pathway and Potentiates Antiproliferative Effects of Gemcitabine on Pancreatic Cancer Cells

(2009) N. H. Thoennissen et al.   CANCER RESEARCH

Cucurbitacin I elicits anoikis sensitization, inhibits cellular invasion and in vivo tumor formation ability of nasopharyngeal carcinoma cells

(2009) Vivian W.Y. Lui et al.   CARCINOGENESIS

Artemisinin and its derivatives: a novel class of anti-malarial and anti-cancer agents

(2009) Devdutt Chaturvedi et al.   CHEMICAL SOCIETY REVIEWS

Anticancer activities of artemisinin and its bioactive derivatives

(2009) Gary L. Firestone et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Effect of artesunate on inhibiting proliferation and inducing apoptosis of SP2/0 myeloma cells through affecting NFκB p65

(2009) Shihui Li et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Growth inhibitory effects of dihydroartemisinin on pancreatic cancer cells: involvement of cell cycle arrest and inactivation of nuclear factor-κB

(2009) Hua Chen et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Structural Basis of Serine/Threonine Phosphatase Inhibition by the Archetypal Small Molecules Cantharidin and Norcantharidin

(2009) I. Bertini et al.   JOURNAL OF MEDICINAL CHEMISTRY

Triptolide is an inhibitor of RNA polymerase I and II-dependent transcription leading predominantly to down-regulation of short-lived mRNA

(2009) S. Vispe et al.   MOLECULAR CANCER THERAPEUTICS

Heme Mediates Cytotoxicity from Artemisinin and Serves as a General Anti-Proliferation Target

(2009) Shiming Zhang et al.   PLoS One

Protein tyrosine kinase, JNK, and ERK involvement in pseudolaric acid B-induced apoptosis of human breast cancer MCF-7 cells1

(2008) Jing-hua YU et al.   ACTA PHARMACOLOGICA SINICA

Celastrol inhibits the growth of human glioma xenografts in nude mice through suppressing VEGFR expression

(2008) Yulun Huang et al.   CANCER LETTERS

Tanshinone I suppresses growth and invasion of human breast cancer cells, MDA-MB-231, through regulation of adhesion molecules

(2008) I. T. Nizamutdinova et al.   CARCINOGENESIS

Cytotoxic and Anti-oxidant Activities of Lanostane-Type Triterpenes Isolated from Poria cocos

(2008) Liang Zhou et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Experimental Therapy of Hepatoma with Artemisinin and Its Derivatives: In vitro and In vivo Activity, Chemosensitization, and Mechanisms of Action

(2008) J. Hou et al.   CLINICAL CANCER RESEARCH

Combined antitumor activity of cucurbitacin B and docetaxel in laryngeal cancer

(2008) Tingyan Liu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cucurbitacin B markedly inhibits growth and rapidly affects the cytoskeleton in glioblastoma multiforme

(2008) Dong Yin et al.   INTERNATIONAL JOURNAL OF CANCER

Artemisinin reduces human melanoma cell migration by down-regulating αVβ3 integrin and reducing metalloproteinase 2 production

(2008) Elisabetta Buommino et al.   INVESTIGATIONAL NEW DRUGS

Artemisinin Blocks Prostate Cancer Growth and Cell Cycle Progression by Disrupting Sp1 Interactions with the Cyclin-dependent Kinase-4 (CDK4) Promoter and Inhibiting CDK4 Gene Expression

(2008) Jamin A. Willoughby et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dihydroartemisinin induces apoptosis and sensitizes human ovarian cancer cells to carboplatin therapy

(2008) Tao Chen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Actin-Aggregating Cucurbitacins fromPhysocarpus capitatus

(2008) Katherine N. Maloney et al.   JOURNAL OF NATURAL PRODUCTS

Bcl-2 Family Proteins Were Involved in Pseudolaric Acid B–Induced Autophagy in Murine Fibrosarcoma L929 Cells

(2008) Jinghua Yu et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Cucurbitacin B induces differentiation, cell cycle arrest, and actin cytoskeletal alterations in myeloid leukemia cells

(2008) Talin Haritunians et al.   LEUKEMIA RESEARCH

Activation of Heat Shock and Antioxidant Responses by the Natural Product Celastrol: Transcriptional Signatures of a Thiol-targeted Molecule

(2008) Amy Trott et al.   MOLECULAR BIOLOGY OF THE CELL

A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cells

(2008) T. Zhang et al.   MOLECULAR CANCER THERAPEUTICS

Anticancer effects of tanshinone I in human non-small cell lung cancer

(2008) C.-Y. Lee et al.   MOLECULAR CANCER THERAPEUTICS

Growth Inhibition and Apoptosis Induction by Tanshinone IIA in Human Colon Adenocarcinoma Cells

(2008) Chin-Cheng Su et al.   PLANTA MEDICA