An overview of investigational antiapoptotic drugs with potential application for the treatment of neurodegenerative disorders

Leptin: A Novel Therapeutic Strategy for Alzheimer's Disease

(2017) Nikolaos Tezapsidis et al.   JOURNAL OF ALZHEIMERS DISEASE

Increase of BDNF Serum Concentration in Lithium Treated Patients with Early Alzheimer's Disease

(2017) Thomas Leyhe et al.   JOURNAL OF ALZHEIMERS DISEASE

Vitamin E Paradox in Alzheimer's Disease: It Does Not Prevent Loss of Cognition and May Even Be Detrimental

(2017) Ana Lloret et al.   JOURNAL OF ALZHEIMERS DISEASE

Apoptosis and Human Diseases: Mitochondrion Damage and Lethal Role of Released Cytochrome c as Proapoptotic Protein

(2012) P. Caroppi et al.   CURRENT MEDICINAL CHEMISTRY

Caspase Activation in Alzheimer's Disease: Early to Rise and Late to Bed

(2011) Troy T. Rohn et al.   REVIEWS IN THE NEUROSCIENCES

Role of Huperzine a in the Treatment of Alzheimer's Disease

(2009) Alicia R Desilets et al.   ANNALS OF PHARMACOTHERAPY

Promising Strategies for the Prevention of Dementia

(2009) Laura E. Middleton et al.   ARCHIVES OF NEUROLOGY

Novel Regimens and Delivery Systems in the Pharmacological Treatment of Alzheimerʼs Disease

(2009) Nazem Bassil et al.   CNS DRUGS

Potential Mechanisms Involved in the Prevention of Neurodegenerative Diseases by Lithium

(2009) Antoni Camins et al.   CNS Neuroscience & Therapeutics

The Antiapoptotic Activity of Melatonin in Neurodegenerative Diseases

(2009) Xin Wang   CNS Neuroscience & Therapeutics

Resveratrol and Neurodegenerative Diseases: Activation of SIRT1 as the Potential Pathway towards Neuroprotection

(2009) Merce Pallas et al.   CURRENT NEUROVASCULAR RESEARCH

Lenalidomide (Revlimid®) administration at symptom onset is neuroprotective in a mouse model of amyotrophic lateral sclerosis

(2009) Arie Neymotin et al.   EXPERIMENTAL NEUROLOGY

Huperzine A protects isolated rat brain mitochondria against β-amyloid peptide

(2009) Xin Gao et al.   FREE RADICAL BIOLOGY AND MEDICINE

Association of Plasma Leptin Levels With Incident Alzheimer Disease and MRI Measures of Brain Aging

(2009) Wolfgang Lieb   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Lithium Trial in Alzheimer's Disease

(2009) Harald Hampel et al.   JOURNAL OF CLINICAL PSYCHIATRY

Efficacy and safety of natural acetylcholinesterase inhibitor huperzine A in the treatment of Alzheimer’s disease: an updated meta-analysis

(2009) Bai-song Wang et al.   JOURNAL OF NEURAL TRANSMISSION

Memantine lowers amyloid-β peptide levels in neuronal cultures and in APP/PS1 transgenic mice

(2009) George M. Alley et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Long-term melatonin administration protects brain mitochondria from aging

(2009) Miguel Carretero et al.   JOURNAL OF PINEAL RESEARCH

Protection against cognitive deficits and markers of neurodegeneration by long-term oral administration of melatonin in a transgenic model of Alzheimer disease

(2009) James M. Olcese et al.   JOURNAL OF PINEAL RESEARCH

Mitochondrial membrane permeabilization in neuronal injury

(2009) Lorenzo Galluzzi et al.   NATURE REVIEWS NEUROSCIENCE

Donepezil delays progression to AD in MCI subjects with depressive symptoms

(2009) P. H. Lu et al.   NEUROLOGY

Leptin inhibits glycogen synthase kinase-3β to prevent tau phosphorylation in neuronal cells

(2009) Steven J. Greco et al.   NEUROSCIENCE LETTERS

A Double-Blind, Delayed-Start Trial of Rasagiline in Parkinson's Disease

(2009) C. Warren Olanow et al.   NEW ENGLAND JOURNAL OF MEDICINE

Adenosine, adenosine A2A antagonists, and Parkinson's disease

(2009) P. Jenner et al.   PARKINSONISM & RELATED DISORDERS

Adenosine A2Areceptor antagonist istradefylline (KW-6002) reduces “off” time in Parkinson's disease: A double-blind, randomized, multicenter clinical trial (6002-US-005)

(2008) Peter A. LeWitt et al.   ANNALS OF NEUROLOGY

Minocycline and neurodegenerative diseases

(2008) Hye-Sun Kim et al.   BEHAVIOURAL BRAIN RESEARCH

Leptin reduces Alzheimer’s disease-related tau phosphorylation in neuronal cells

(2008) Steven J. Greco et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mechanisms of neuronal death in disease: defining the models and the players

(2008) Elena M. Ribe et al.   BIOCHEMICAL JOURNAL

Current approaches in the treatment of Alzheimer's disease

(2008) Reena S. Shah et al.   BIOMEDICINE & PHARMACOTHERAPY

Trans-Resveratrol: A Magical Elixir of Eternal Youth?

(2008) Francisco Orallo   CURRENT MEDICINAL CHEMISTRY

Improved mitochondrial function and increased life span after chronic melatonin treatment in senescent prone mice

(2008) María I. Rodríguez et al.   EXPERIMENTAL GERONTOLOGY

Pharmacological treatment in moderate-to-severe Alzheimer's disease

(2008) Ging-Yuek Robin Hsiung et al.   EXPERT OPINION ON PHARMACOTHERAPY

Minocycline reduces the development of abnormal tau species in models of Alzheimer’s disease

(2008) Wendy Noble et al.   FASEB JOURNAL

Ginkgo biloba for Prevention of DementiaA Randomized Controlled Trial

(2008) Steven T. DeKosky   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Neuroprotective Effects of Resveratrol on MPTP-Induced Neuron Loss Mediated by Free Radical Scavenging

(2008) Kwok-Tung Lu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Coenzyme Q10 Attenuates β-Amyloid Pathology in the Aged Transgenic Mice with Alzheimer Presenilin 1 Mutation

(2008) Xifei Yang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Melatonin protects the mitochondria from oxidative damage reducing oxygen consumption, membrane potential, and superoxide anion production

(2008) Ana López et al.   JOURNAL OF PINEAL RESEARCH

Antioxidant Therapy in Alzheimers Disease: Theory and Practice

(2008) Gjumrakch Aliev et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

CEP-1347 reduces mutant huntingtin-associated neurotoxicity and restores BDNF levels in R6/2 mice

(2008) Barbara L. Apostol et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Cell cycle re-entry mediated neurodegeneration and its treatment role in the pathogenesis of Alzheimer's disease

(2008) Hyoung-gon Lee et al.   NEUROCHEMISTRY INTERNATIONAL

MIXED LINEAGE KINASE INHIBITOR CEP- 1347 FAILS TO DELAY DISABILITY IN EARLY PARKINSON DISEASE

(2008) L. H. Wang et al.   NEUROLOGY

A 12-week, placebo-controlled study (6002-US-006) of istradefylline in Parkinson disease

(2008) M. Stacy et al.   NEUROLOGY

ALS drug development: Reflections from the past and a way forward

(2008) Swati Aggarwal et al.   Neurotherapeutics

Resveratrol and novel potent activators of SIRT1: effects on aging and age-related diseases

(2008) Mitchell D Knutson et al.   NUTRITION REVIEWS

Mitochondrial Ca2+ Overload Underlies Aβ Oligomers Neurotoxicity Providing an Unexpected Mechanism of Neuroprotection by NSAIDs

(2008) Sara Sanz-Blasco et al.   PLoS One

Lithium may slow progression of amyotrophic lateral sclerosis, but further study is needed

(2008) R. S. Bedlack et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lithium delays progression of amyotrophic lateral sclerosis

(2008) F. Fornai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adenosine A2A receptors in Parkinson’s disease treatment

(2008) Marek Cieślak et al.   Purinergic Signalling

Bile acids and apoptosis modulation: an emerging role in experimental Alzheimer's disease

(2008) Rita M. Ramalho et al.   TRENDS IN MOLECULAR MEDICINE