Targeting the MET oncogene in cancer and metastases

Phase I study of SCH 900105 (SC), an anti-hepatocyte growth factor (HGF) monoclonal antibody (MAb), as a single agent and in combination with erlotinib (E) in patients (pts) with advanced solid tumors.

(2017) A. Patnaik et al.   JOURNAL OF CLINICAL ONCOLOGY

An Orally Bioavailable c-Met Kinase Inhibitor Potently Inhibits Brain Tumor Malignancy and Growth

(2012) Fadila Guessous et al.   Anti-Cancer Agents in Medicinal Chemistry

Preexistence and Clonal Selection of MET Amplification in EGFR Mutant NSCLC

(2010) Alexa B. Turke et al.   CANCER CELL

Biochemical Characterization of AMG 102: A Neutralizing, Fully Human Monoclonal Antibody to Human and Nonhuman Primate Hepatocyte Growth Factor

(2010) T. L. Burgess et al.   MOLECULAR CANCER THERAPEUTICS

Structural basis for agonism and antagonism of hepatocyte growth factor

(2010) W. D. Tolbert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

N-(3-fluoro-4-(2-arylthieno[3,2-b]pyridin-7-yloxy)phenyl)-2-oxo-3-phenylimidazolidine-1-carboxamides: A novel series of dual c-Met/VEGFR2 receptor tyrosine kinase inhibitors

(2009) Stéphane Raeppel et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Genetic Link Between Cancer and Thrombosis

(2009) Carla Boccaccio et al.   JOURNAL OF CLINICAL ONCOLOGY

IncreasedMETGene Copy Number Negatively Affects Survival of Surgically Resected Non–Small-Cell Lung Cancer Patients

(2009) Federico Cappuzzo et al.   JOURNAL OF CLINICAL ONCOLOGY

SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo

(2009) S. G. Buchanan et al.   MOLECULAR CANCER THERAPEUTICS

Screening for Epidermal Growth Factor Receptor Mutations in Lung Cancer

(2009) Rafael Rosell et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dual MET–EGFR combinatorial inhibition against T790M-EGFR-mediated erlotinib-resistant lung cancer

(2008) Z Tang et al.   BRITISH JOURNAL OF CANCER

"Active" Cancer Immunotherapy by Anti-Met Antibody Gene Transfer

(2008) E. Vigna et al.   CANCER RESEARCH

Showering c-MET-dependent cancers with drugs

(2008) Beatrice S. Knudsen et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

A High Affinity Hepatocyte Growth Factor-binding Site in the Immunoglobulin-like Region of Met

(2008) Cristina Basilico et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MET as a target for treatment of chest tumors

(2008) Nicole A. Cipriani et al.   LUNG CANCER

Drug development of MET inhibitors: targeting oncogene addiction and expedience

(2008) Paolo M. Comoglio et al.   NATURE REVIEWS DRUG DISCOVERY

Hepatocyte growth factor and Met in tumor biology and therapeutic approach with NK4

(2008) Kunio Matsumoto et al.   PROTEOMICS