Journal
EXPERT OPINION ON INVESTIGATIONAL DRUGS
Volume 18, Issue 5, Pages 609-616Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1517/14728220902852570
Keywords
biologics; corticosteroids; treatment; uveitis
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The management of complex uveitis is often based around the use of oral corticosteroids. To spare the side effects of corticosteroids, second-line oral immunosuppressant drugs are used. Newer systemic immunosuppressive drugs, including biologics, and locally delivered treatments are being evaluated. This article reviews current conventional treatments, discusses their limitations and evaluates newer treatment strategies. Current theories about the pathogenesis of uveitis and potential targets for treatment are discussed in this context. We are still in search of a low-risk, where possible, locally delivered and targeted treatment for uveitis.
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