Article
Oncology
Zeynep Eroglu, Y. Ann Chen, Inna Smalley, Jiannong Li, Joseph K. Markowitz, Andrew S. Brohl, Leticia Tetteh, Hayley Taylor, Vernon K. Sondak, Nikhil I. Khushalani, Keiran S. M. Smalley
Summary: In this study, the efficacy and safety of vemurafenib and cobimetinib in combination with different doses of the HSP90 inhibitor XL888 for the treatment of advanced melanoma were explored. The study found that this combination therapy showed activity in some patients, but also had significant toxicity.
Article
Biochemistry & Molecular Biology
Tanya Ju-Ngam, Nichanun McMillan, Mamoru Yoshimizu, Hisae Kasai, Ratree Wongpanya, Prapansak Srisapoome
Summary: This research conducted molecular characterization and biofunctional analyses of Hsp40 and Hsp90 genes in giant river prawns under various stress conditions. The highest similarity scores of these genes were found with crustaceans. Expression patterns of Mr-hsp40 and Mr-hsp90 were different under Aeromonas hydrophila challenge and heat-cold shock conditions, highlighting their significant roles in stress responses.
Article
Engineering, Biomedical
Kwang Suk Lim, Daniel Y. Lee, Seungmin Han, David A. Bull, Young-Wook Won
Summary: HSP90 is crucial for cancer cell survival, and incorporating HSP90 inhibitors into antibodies through biological affinity binding can enhance targeted delivery and improve anti-cancer efficacy.
Review
Cell Biology
Xiude Ren, Tao Li, Wei Zhang, Xuejun Yang
Summary: Heat-shock protein 90 (HSP90) is an important molecule chaperone associated with tumorigenesis and malignancy. It plays a role in the malignant behaviors of cancer cells, but currently there are no effective single-agent treatments. Combining HSP90 inhibitors with other anticancer therapies may be a better strategy.
Review
Pharmacology & Pharmacy
Hui Yi Liew, Xin Yoong Tan, Hong Hao Chan, Kooi Yeong Khaw, Yong Sze Ong
Summary: This review analyzes the chemical and biological activities of natural Hsp90 inhibitors, discusses their efficacy in tumor models, and explores their pharmacodynamics and pharmacokinetics.
PHARMACOLOGICAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Stefan Tukaj, Krzysztof Sitko
Summary: Over a hundred different autoimmune diseases have been described to date, affecting various organs including the skin. The loss of immune tolerance in autoimmune diseases leads to chronic inflammation and tissue damage. Current treatments focus on immunosuppression but may cause serious adverse effects. Heat shock proteins Hsp90 and Hsp70 have been identified as potential therapeutic targets for autoimmune skin diseases.
Article
Virology
Beth H. Thompson, Colin P. Sharp, Inga R. Dry, Robert G. Dalziel, Eleanor R. Gaunt
Summary: This study validates the pro-viral roles of cellular protein TTC4 and heat shock protein 90 (HSP90) during BoHV-1 replication. TTC4 expression is upregulated during infection, depletion impairs protein production, and overexpression increases infectious virus production. Inhibition of HSP90 using geldanamycin inhibits protein production and viral genome replication.
Review
Plant Sciences
Yeeun Kang, Kwanuk Lee, Ken Hoshikawa, Myeongyong Kang, Seonghoe Jang
Summary: The effects of climate change, such as increased global temperatures and abnormal weather events, are causing concerns for plant vegetation and crop productivity. This review focuses on the molecular processes of plants in response to heat stress, with emphasis on the classification and functions of heat shock proteins. Developing vegetable crops with enhanced thermotolerance using genetic tools is crucial to alleviate the adverse effects of heat stress.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Pharmacology & Pharmacy
Megha Yadav, Ankit Kumar Singh, Adarsh Kumar, Suresh Thareja, Pradeep Kumar
Summary: Heat shock protein 90 (Hsp90) is a chaperone protein that plays important roles in various proteins and signaling pathways. Its functions are not limited to cancer but also extend to other diseases. This review provides a compilation of the pharmacological profile of Hsp90 inhibitors, associated problems, and suggested remedies.
CURRENT PHARMACEUTICAL DESIGN
(2022)
Article
Horticulture
Chao Gong, Qiangqiang Pang, Zhiliang Li, Zhenxing Li, Riyuan Chen, Guangwen Sun, Baojuan Sun
Summary: Under high temperature stress, Hsf and Hsp gene families are activated in eggplant cells, enhancing thermotolerance by removing denatured proteins. Specifically, upon exposure to heat stress, the majority of Hsf and Hsp genes in eggplant show increased expression levels.
Article
Agronomy
Chuanbei Tian, Yaying Li, Yixia Wu, Wenqiang Chu, Huai Liu
Summary: In fluctuating climatic environments, heat acclimation in predatory mites is a superior adaptation strategy for effective agricultural pest management. The sustained accumulation of HSP70 proteins results in predatory mites with thermotolerance advantage, promoting their biological control function to pests. The divergent constitutive regulation of HSP70 to a thermal environment allows predators to adapt flexibly to extreme stress.
PEST MANAGEMENT SCIENCE
(2021)
Article
Parasitology
Hiroka Tsutsumi, Moeko Abe, Naohiro Uchida, Mitsuyoshi Takiguchi, Masahiro Yamasaki
Summary: This study investigated the role of heat shock protein 90 (HSP90) in the proliferation and survival of Babesia gibsoni in vitro. It was found that an anti-BgHSP90 antibody did not directly inhibit the entry of the parasite into erythrocytes. Two HSP90 inhibitors, geldanamycin (GA) and tanespimycin (17AAG), were shown to decrease DNA synthesis and the number of infected erythrocytes, indicating the important roles of BgHSP90 in the proliferation of the parasite. GA was found to suppress the superoxide generation in canine neutrophils.
EXPERIMENTAL PARASITOLOGY
(2023)
Article
Oncology
Jinho Kang, Hye-Jin Lee, Jimin Lee, Jinhwa Hong, Yeul Hong Kim, Mary L. Disis, Jeong-An Gim, Kyong Hwa Park
Summary: This study identified HSP90-derived MHC class II epitopes using in silico algorithms and validated their effectiveness using in vivo experiments. The HSP90 peptide vaccines showed potential for improving breast cancer treatment by activating T cells, increasing T-cell recruitment in the immune microenvironment, and rearranging TCRE3.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Veterinary Sciences
Samuel A. Atkin, Abu Saleh Md Moin, Stephen L. Atkin, Alexandra E. Butler
Summary: This study investigated the effects of hypoglycemia on the heat shock-related protein pathway. The results showed that hypoglycemia significantly decreased the expression of HSP90, 70, 27, and ubiquitin proteins, which are important for the protective response against heat stress.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Oncology
Behnoush Khaledian, Ayumu Taguchi, Kazuo Shin-ya, Lisa Kondo-Ida, Noritaka Kagaya, Motoshi Suzuki, Taisuke Kajino, Tomoya Yamaguchi, Yukako Shimada, Takashi Takahashi
Summary: The study identified geldanamycin as a potential inhibitor of ROR1 by destabilizing and degrading its protein expression through the ubiquitin/proteasome pathway, leading to a significant suppression of cell proliferation in lung adenocarcinoma cell lines. This suggests that HSP90 inhibition could be a promising therapeutic strategy in ROR1-positive lung adenocarcinoma.
