Emerging targets for the treatment of scleroderma

Interspecies Comparison of Human and Murine Scleroderma Reveals IL-13 and CCL2 as Disease Subset-Specific Targets

(2012) Matthew B. Greenblatt et al.   AMERICAN JOURNAL OF PATHOLOGY

Prostaglandin E2 protects murine lungs from bleomycin-induced pulmonary fibrosis and lung dysfunction

(2011) Ryan T. Dackor et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Prostaglandin E2As an Inhibitory Modulator of Fibrogenesis in Human Lung Allografts

(2011) Natalie M. Walker et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Expert Agreement on EULAR/EUSTAR Recommendations for the Management of Systemic Sclerosis

(2011) K. M. WALKER et al.   JOURNAL OF RHEUMATOLOGY

mPGES-1 null mice are resistant to bleomycin-induced skin fibrosis

(2011) Matthew R McCann et al.   ARTHRITIS RESEARCH & THERAPY

Interstitial lung disease in systemic sclerosis

(2010) Guillaume Bussone et al.   AUTOIMMUNITY REVIEWS

Fibrosis in systemic sclerosis: Emerging concepts and implications for targeted therapy

(2010) Jun Wei et al.   AUTOIMMUNITY REVIEWS

Actual status of antiinterleukin-1 therapies in rheumatic diseases

(2010) Matthias Geyer et al.   CURRENT OPINION IN RHEUMATOLOGY

Epithelial Cells Promote Fibroblast Activation via IL-1α in Systemic Sclerosis

(2010) Nima Aden et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The skin of patients with systemic sclerosis softened during the treatment with anti-IL-6 receptor antibody tocilizumab

(2010) Y. Shima et al.   RHEUMATOLOGY

B cell depletion in diffuse progressive systemic sclerosis: safety, skin score modification and IL-6 modulation in an up to thirty-six months follow-up open-label trial

(2010) Silvia Bosello et al.   ARTHRITIS RESEARCH & THERAPY

B cell block: is rituximab a new possible treatment for systemic sclerosis?

(2010) Andrew Leask   Journal of Cell Communication and Signaling

Role of prostaglandins in fibroblast activation and fibrosis

(2010) Richard Stratton et al.   Journal of Cell Communication and Signaling

Commentary on a recent article—“A prostacyclin analogue, Iloprost, protects from bleomycin-induced fibrosis in mice” Zhu Y et al. Respir Res. 2010 Mar 20;11(1):34

(2010) Richard Stratton et al.   Journal of Cell Communication and Signaling

EULAR recommendations for the treatment of systemic sclerosis: a report from the EULAR Scleroderma Trials and Research group (EUSTAR)

(2009) O Kowal-Bielecka et al.   ANNALS OF THE RHEUMATIC DISEASES

B cell depletion with rituximab in patients with diffuse cutaneous systemic sclerosis

(2009) Robert Lafyatis et al.   ARTHRITIS AND RHEUMATISM

Observational Study of Treatment Outcome in Early Diffuse Cutaneous Systemic Sclerosis

(2009) A. L. HERRICK et al.   JOURNAL OF RHEUMATOLOGY

Prostaglandin F2α receptor signaling facilitates bleomycin-induced pulmonary fibrosis independently of transforming growth factor-β

(2009) Toru Oga et al.   NATURE MEDICINE

Cutaneous Chronic Graft-Versus-Host Disease Does Not Have the Abnormal Endothelial Phenotype or Vascular Rarefaction Characteristic of Systemic Sclerosis

(2009) Jo Nadine Fleming et al.   PLoS One

Improved survival in systemic sclerosis is associated with better ascertainment of internal organ disease: a retrospective cohort study

(2009) S.I. Nihtyanova et al.   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

Experience with rituximab in scleroderma: results from a 1-year, proof-of-principle study

(2009) Dimitrios Daoussis et al.   RHEUMATOLOGY

Bronchoalveoloar lavage fluid cytokines and chemokines as markers and predictors for the outcome of interstitial lung disease in systemic sclerosis patients

(2009) Katrin Schmidt et al.   ARTHRITIS RESEARCH & THERAPY

CD19 Regulates Skin and Lung Fibrosis via Toll-Like Receptor Signaling in a Model of Bleomycin-Induced Scleroderma

(2008) Ayumi Yoshizaki et al.   AMERICAN JOURNAL OF PATHOLOGY

Rituximab in diffuse cutaneous systemic sclerosis: an open-label clinical and histopathological study

(2008) V Smith et al.   ANNALS OF THE RHEUMATIC DISEASES

Targeting the TGFβ, endothelin-1 and CCN2 axis to combat fibrosis in scleroderma

(2008) Andrew Leask   CELLULAR SIGNALLING

New developments in localized scleroderma

(2008) Francesco Zulian   CURRENT OPINION IN RHEUMATOLOGY

Capillary Regeneration in Scleroderma: Stem Cell Therapy Reverses Phenotype?

(2008) Jo N. Fleming et al.   PLoS One

Molecular Subsets in the Gene Expression Signatures of Scleroderma Skin

(2008) Ausra Milano et al.   PLoS One

Renal manifestations of systemic sclerosis--clinical features and outcome assessment

(2008) C. P. Denton   RHEUMATOLOGY

Proteomic analysis of scleroderma lesional skin reveals activated wound healing phenotype of epidermal cell layer

(2008) N. Aden et al.   RHEUMATOLOGY

Effects of cyclophosphamide on pulmonary function in patients with scleroderma and interstitial lung disease: a systematic review and meta-analysis of randomized controlled trials and observational prospective cohort studies

(2008) Carlotta Nannini et al.   ARTHRITIS RESEARCH & THERAPY

Long-term follow-up results after autologous haematopoietic stem cell transplantation for severe systemic sclerosis

(2007) M C Vonk et al.   ANNALS OF THE RHEUMATIC DISEASES