Emerging drugs for pulmonary hypertension

Addition of Sildenafil to Long-Term Intravenous Epoprostenol Therapy in Patients with Pulmonary Arterial Hypertension

(2013) Gérald Simonneau   ANNALS OF INTERNAL MEDICINE

AMBRISENTAN THERAPY IN PATIENTS WITH PULMONARY ARTERIAL HYPERTENSION: 2-YEAR OUTCOME

(2013) Ronald J. Oudiz   CHEST

l-Citrulline ameliorates chronic hypoxia-induced pulmonary hypertension in newborn piglets

(2009) Madhumita Ananthakrishnan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Evidence of Dysfunction of Endothelial Progenitors in Pulmonary Arterial Hypertension

(2009) Mark Toshner et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Evaluating Health-Related Quality of Life, Work Ability, and Disability in Pulmonary Arterial Hypertension

(2009) Melvyn Rubenfire et al.   CHEST

Selective Serotonin Reuptake Inhibitors and the Incidence and Outcome of Pulmonary Hypertension

(2009) Sanjiv J. Shah et al.   CHEST

The Right Ventricle Under Pressure

(2009) Harm J. Bogaard et al.   CHEST

ACCF/AHA 2009 Expert Consensus Document on Pulmonary Hypertension

(2009) et al.   CIRCULATION

Tadalafil Therapy for Pulmonary Arterial Hypertension

(2009) Nazzareno Galiè et al.   CIRCULATION

Cost-Utility of Treatments for Pulmonary Arterial Hypertension

(2009) Margaret C. Garin et al.   CLINICAL DRUG INVESTIGATION

Novel approaches to the pharmacotherapy of pulmonary arterial hypertension

(2009) Karen M. Olsson et al.   DRUG DISCOVERY TODAY

A meta-analysis of randomized controlled trials in pulmonary arterial hypertension

(2009) N. Galie et al.   EUROPEAN HEART JOURNAL

Liver toxicity: the Achilles' heel of endothelin receptor antagonist therapy?

(2009) M. M. Hoeper   EUROPEAN RESPIRATORY JOURNAL

Simvastatin and sildenafil combine to attenuate pulmonary hypertension

(2009) L. Zhao et al.   EUROPEAN RESPIRATORY JOURNAL

First acute haemodynamic study of soluble guanylate cyclase stimulator riociguat in pulmonary hypertension

(2009) F. Grimminger et al.   EUROPEAN RESPIRATORY JOURNAL

Vardenafil treatment for patients with pulmonary arterial hypertension: a multicentre, open-label study

(2009) Z-C Jing et al.   HEART

Effects of Long-Acting Beraprost Sodium (TRK-100STP) in Japanese Patients With Pulmonary Arterial Hypertension

(2009) Takeyoshi Kunieda et al.   International Heart Journal

Diagnosis, Assessment, and Treatment of Non-Pulmonary Arterial Hypertension Pulmonary Hypertension

(2009) Marius M. Hoeper et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Genetics and Genomics of Pulmonary Arterial Hypertension

(2009) Rajiv D. Machado et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Updated Evidence-Based Treatment Algorithm in Pulmonary Arterial Hypertension

(2009) Robyn J. Barst et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Cellular and Molecular Basis of Pulmonary Arterial Hypertension

(2009) Nicholas W. Morrell et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Diagnosis and Assessment of Pulmonary Arterial Hypertension

(2009) David B. Badesch et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Inflammation, Growth Factors, and Pulmonary Vascular Remodeling

(2009) Paul M. Hassoun et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Updated Clinical Classification of Pulmonary Hypertension

(2009) Gérald Simonneau et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Pathology of Pulmonary Arterial Hypertension

(2009) Rubin Tuder   SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE

Contractile regulation by overexpressed ETA requires intact T tubules in adult rat ventricular myocytes

(2008) Ka Young Chung et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Connective Tissue Disease–associated Pulmonary Arterial Hypertension in the Modern Treatment Era

(2008) Robin Condliffe et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Cicletanine for the Treatment of Pulmonary Arterial Hypertension

(2008) Aaron B. Waxman et al.   ARCHIVES OF INTERNAL MEDICINE

Therapeutic potential of RhoA/Rho kinase inhibitors in pulmonary hypertension

(2008) M Oka et al.   BRITISH JOURNAL OF PHARMACOLOGY

Role of endothelin receptors on basal and endothelin-1-stimulated lung myofibroblast proliferationThis article is one of a selection of papers published in the special issue (part 1 of 2) on Forefronts in Endothelin.

(2008) Annick Préfontaine et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Sildenafil Improves Health-Related Quality of Life in Patients With Pulmonary Arterial Hypertension*

(2008) Joanna Pepke-Zaba et al.   CHEST

Sitaxsentan for the Treatment of Pulmonary Arterial Hypertension

(2008) Raymond L. Benza et al.   CHEST

Uncertainties in the Diagnosis and Treatment of Pulmonary Arterial Hypertension

(2008) Hossein A. Ghofrani et al.   CIRCULATION

Mechanisms of Cardiac Dysfunction Associated With Tyrosine Kinase Inhibitor Cancer Therapeutics

(2008) Ming Hui Chen et al.   CIRCULATION

Combined Tyrosine and Serine/Threonine Kinase Inhibition by Sorafenib Prevents Progression of Experimental Pulmonary Hypertension and Myocardial Remodeling

(2008) Martina Klein et al.   CIRCULATION

Ambrisentan for the Treatment of Pulmonary Arterial Hypertension

(2008) Nazzareno Galiè et al.   CIRCULATION

Inhibition of endothelin receptors in the treatment of pulmonary arterial hypertension: does selectivity matter?

(2008) Christian F. Opitz et al.   EUROPEAN HEART JOURNAL

Long-term effects of bosentan in patients with HIV-associated pulmonary arterial hypertension

(2008) B. Degano et al.   EUROPEAN RESPIRATORY JOURNAL

Pharmacokinetic Interaction Between Tadalafil and Bosentan in Healthy Male Subjects

(2008) Rebecca E. Wrishko et al.   JOURNAL OF CLINICAL PHARMACOLOGY

A Long-Acting and Highly Selective Prostacyclin Receptor Agonist Prodrug, 2- -N-(methylsulfonyl)acetamide (NS-304), Ameliorates Rat Pulmonary Hypertension with Unique Relaxant Responses of Its Active Form,  acetic Acid (MRE-269), on Rat Pulmonary Artery

(2008) K. Kuwano et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Pharmacology of Macitentan, an Orally Active Tissue-Targeting Dual Endothelin Receptor Antagonist

(2008) M. Iglarz et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Treatment of patients with mildly symptomatic pulmonary arterial hypertension with bosentan (EARLY study): a double-blind, randomised controlled trial

(2008) N Galiè et al.   LANCET

The nitrate–nitrite–nitric oxide pathway in physiology and therapeutics

(2008) Jon O. Lundberg et al.   NATURE REVIEWS DRUG DISCOVERY

Therapeutic targets in pulmonary arterial hypertension

(2008) Christopher J. Rhodes et al.   PHARMACOLOGY & THERAPEUTICS

VPAC and PAC receptors: From ligands to function

(2008) Louise Dickson et al.   PHARMACOLOGY & THERAPEUTICS

Mitochondrial metabolism, redox signaling, and fusion: a mitochondria-ROS-HIF-1α-Kv1.5 O2-sensing pathway at the intersection of pulmonary hypertension and cancer

(2007) Stephen L. Archer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism

(2007) Edzard Schwedhelm et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Pulmonary arterial hypertension associated with fenfluramine exposure: report of 109 cases

(2007) R. Souza et al.   EUROPEAN RESPIRATORY JOURNAL