Emerging drugs for high-grade osteosarcoma

Physiological and Oncogenic Aurora-A Pathway

(2012) Toshiaki SAEKI et al.   International Journal of Biological Sciences

NVP-BEZ235 as a New Therapeutic Option for Sarcomas

(2010) M. C. Manara et al.   CLINICAL CANCER RESEARCH

Denosumab in patients with giant-cell tumour of bone: an open-label, phase 2 study

(2010) David Thomas et al.   LANCET ONCOLOGY

Role of Glutathione Transferases in the Mechanism of Brostallicin Activation

(2009) Silvia Pezzola et al.   BIOCHEMISTRY

Correlation between clinical outcome and growth factor pathway expression in osteogenic sarcoma

(2009) Ayesha Abdeen et al.   CANCER

Addition of muramyl tripeptide to chemotherapy for patients with newly diagnosed metastatic osteosarcoma

(2009) Alexander J. Chou et al.   CANCER

The Insulin-like Growth Factor-1 Receptor-Targeting Antibody, CP-751,871, Suppresses Tumor-Derived VEGF and Synergizes with Rapamycin in Models of Childhood Sarcoma

(2009) R. T. Kurmasheva et al.   CANCER RESEARCH

Insulin Receptor Isoform A and Insulin-like Growth Factor II as Additional Treatment Targets in Human Osteosarcoma

(2009) S. Avnet et al.   CANCER RESEARCH

Functional genome screen for therapeutic targets of osteosarcoma

(2009) Umio Yamaguchi et al.   CANCER SCIENCE

A Phase I Dose-Escalation Study of Danusertib (PHA-739358) Administered as a 24-Hour Infusion with and without Granulocyte Colony-Stimulating Factor in a 14-Day Cycle in Patients with Advanced Solid Tumors

(2009) R. B. Cohen et al.   CLINICAL CANCER RESEARCH

Inhibition of Src Phosphorylation Alters Metastatic Potential of Osteosarcoma In vitro but not In vivo

(2009) P. Hingorani et al.   CLINICAL CANCER RESEARCH

Zoledronic Acid Inhibits Both the Osteolytic and Osteoblastic Components of Osteosarcoma Lesions in a Mouse Model

(2009) A. Labrinidis et al.   CLINICAL CANCER RESEARCH

Targeted Therapies in Bone Sarcomas

(2009) K. Scotlandi et al.   CURRENT CANCER DRUG TARGETS

Novel agents in development for pediatric sarcomas

(2009) Dennis PM Hughes   CURRENT OPINION IN ONCOLOGY

Phase 3 randomised study of canfosfamide (Telcyta®, TLK286) versus pegylated liposomal doxorubicin or topotecan as third-line therapy in patients with platinum-refractory or -resistant ovarian cancer

(2009) I. Vergote et al.   EUROPEAN JOURNAL OF CANCER

Prognostic factors and outcomes for osteosarcoma: An international collaboration

(2009) Emilios E. Pakos et al.   EUROPEAN JOURNAL OF CANCER

Novel therapeutic agents for osteosarcoma

(2009) Kathleen O’Day et al.   Expert Review of Anticancer Therapy

Muramyl tripeptide (mifamurtide) for the treatment of osteosarcoma

(2009) Paul A Meyers   Expert Review of Anticancer Therapy

Phase I Pharmacokinetic and Pharmacodynamic Study of the Aurora Kinase Inhibitor Danusertib in Patients With Advanced or Metastatic Solid Tumors

(2009) Neeltje Steeghs et al.   JOURNAL OF CLINICAL ONCOLOGY

Phase 1-2a Multicenter Dose-Ranging Study of Canfosfamide in Combination with Carboplatin and Paclitaxel as First-Line Therapy for Patients with Advanced Non-small Cell Lung Cancer

(2009) Lecia V. Sequist et al.   Journal of Thoracic Oncology

ABC Transporters as Potential Targets for Modulation of Drug Resistance

(2009) L. Gatti et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Sorafenib blocks tumour growth, angiogenesis and metastatic potential in preclinical models of osteosarcoma through a mechanism potentially involving the inhibition of ERK1/2, MCL-1 and ezrin pathways

(2009) Ymera Pignochino et al.   Molecular Cancer

The Role of IGF-1R in Pediatric Malignancies

(2009) S. Y. Kim et al.   ONCOLOGIST

The role of interferons in the treatment of osteosarcoma

(2009) Jeremy Whelan et al.   PEDIATRIC BLOOD & CANCER

Clinical impact of the methotrexate resistance-associated genes C-MYC and dihydrofolate reductase (DHFR) in high-grade osteosarcoma

(2008) I. Scionti et al.   ANNALS OF ONCOLOGY

Autophagy: A Novel Mechanism of Synergistic Cytotoxicity between Doxorubicin and Roscovitine in a Sarcoma Model

(2008) L. A. Lambert et al.   CANCER RESEARCH

Overcoming Glutathione S-Transferase P1-Related Cisplatin Resistance in Osteosarcoma

(2008) M. Pasello et al.   CANCER RESEARCH

The role of mTOR in the management of solid tumors: An overview

(2008) Alex S. Strimpakos et al.   CANCER TREATMENT REVIEWS

Specific Tyrosine Kinase Inhibitors Regulate Human Osteosarcoma Cells In vitro

(2008) Patrick J. Messerschmitt et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Novel bone cancer drugs: investigational agents and control paradigms for primary bone sarcomas (Ewing's sarcoma and osteosarcoma)

(2008) Pete Anderson et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Mechanisms of gene amplification and evidence of coamplification in drug-resistant human osteosarcoma cell lines

(2008) Claudia M. Hattinger et al.   GENES CHROMOSOMES & CANCER

Farnesyl diphosphate synthase is involved in the resistance to zoledronic acid of osteosarcoma cells

(2008) B. Ory et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Phase I Trial of the Novel Mammalian Target of Rapamycin Inhibitor Deforolimus (AP23573; MK-8669) Administered Intravenously Daily for 5 Days Every 2 Weeks to Patients With Advanced Malignancies

(2008) Monica M. Mita et al.   JOURNAL OF CLINICAL ONCOLOGY

Osteosarcoma: The Addition of Muramyl Tripeptide to Chemotherapy Improves Overall Survival—A Report From the Children's Oncology Group

(2008) Paul A. Meyers et al.   JOURNAL OF CLINICAL ONCOLOGY

Novel therapeutic strategy for osteosarcoma targeting osteoclast differentiation, bone-resorbing activity, and apoptosis pathway

(2008) T. Akiyama et al.   MOLECULAR CANCER THERAPEUTICS

Therapy for Osteosarcoma

(2008) Alexander J Chou et al.   PEDIATRIC DRUGS

Initial testing of the VEGFR inhibitor AZD2171 by the pediatric preclinical testing program

(2007) John M. Maris et al.   PEDIATRIC BLOOD & CANCER

Initial testing of dasatinib by the pediatric preclinical testing program

(2007) E. Anders Kolb et al.   PEDIATRIC BLOOD & CANCER

Initial testing (stage 1) of the mTOR inhibitor rapamycin by the pediatric preclinical testing program

(2007) Peter J. Houghton et al.   PEDIATRIC BLOOD & CANCER