Emerging drugs for chronic constipation

Clinical trial: renzapride therapy for constipation-predominant irritable bowel syndrome - multicentre, randomized, placebo-controlled, double-blind study in primary healthcare setting

(2010) A. M. GEORGE et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Novel opioid antagonists for opioid-induced bowel dysfunction and postoperative ileus

(2009) Gerhild Becker et al.   LANCET

Clinical trial: alvimopan for the management of post-operative ileus after abdominal surgery: results of an international randomized, double-blind, multicentre, placebo-controlled clinical study

(2008) M. W. BÜCHLER et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Clinical trial: lubiprostone in patients with constipation-associated irritable bowel syndrome - results of two randomized, placebo-controlled studies

(2008) D. A. DROSSMAN et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Clinical trial: the efficacy, impact on quality of life, and safety and tolerability of prucalopride in severe chronic constipation - a 12-week, randomized, double-blind, placebo-controlled study

(2008) E. M. M. QUIGLEY et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Pilot Study on the Effect of Linaclotide in Patients With Chronic Constipation

(2008) Jeffrey M Johnston et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Identification of Patients with Non-D, Non-C Irritable Bowel Syndrome and Treatment with Renzapride: An Exploratory, Multicenter, Randomized, Double-Blind, Placebo-Controlled Clinical Trial

(2008) R. C. Spiller et al.   DIGESTIVE DISEASES AND SCIENCES

Mosapride

(2008) Monique P Curran et al.   DRUGS

Heat-stable enterotoxin of Escherichia coli (STa) can stimulate duodenal HCO3− secretion via a novel GC-C- and CFTR-independent pathway

(2008) Zachary M. Sellers et al.   FASEB JOURNAL

Prucalopride (Resolor) in the treatment of severe chronic constipation in patients dissatisfied with laxatives

(2008) J Tack et al.   GUT

PEG3350 in the Treatment of Childhood Constipation: A Multicenter, Double-Blinded, Placebo-Controlled Trial

(2008) Samuel Nurko et al.   JOURNAL OF PEDIATRICS

The in vivo gastrointestinal activity of TD-5108, a selective 5-HT4 receptor agonist with high intrinsic activity

(2008) D. T. Beattie et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Methylnaltrexone for Opioid-Induced Constipation in Advanced Illness

(2008) Jay Thomas et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Placebo-Controlled Trial of Prucalopride for Severe Chronic Constipation

(2008) Michael Camilleri et al.   NEW ENGLAND JOURNAL OF MEDICINE

Alvimopan, a peripherally acting mu-opioid receptor (PAM-OR) antagonist for the treatment of opioid-induced bowel dysfunction: Results from a randomized, double-blind, placebo-controlled, dose-finding study in subjects taking opioids for chronic non-cancer pain

(2008) Lynn Webster et al.   PAIN

Lubiprostone for chronic idiopathic constipation and irritable bowel syndrome with constipation

(2008) Richard Saad et al.   Expert Review of Gastroenterology & Hepatology

Multicenter, 4-Week, Double-Blind, Randomized, Placebo-Controlled Trial of Lubiprostone, a Locally-Acting Type-2 Chloride Channel Activator, in Patients With Chronic Constipation

(2007) John F Johanson et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Efficacy and Safety of Mu-Opioid Antagonists in the Treatment of Opioid-Induced Bowel Dysfunction: Systematic Review and Meta-analysis of Randomized Controlled Trials

(2007) Ewan McNicol et al.   PAIN MEDICINE