Inconsistencies surrounding the risk of adverse outcomes with concomitant use of clopidogrel and proton pump inhibitors

Outcomes With Concurrent Use of Clopidogrel and Proton-Pump Inhibitors

(2013) Wayne A. Ray   ANNALS OF INTERNAL MEDICINE

Proton-Pump Inhibitors Are Associated With Increased Cardiovascular Risk Independent of Clopidogrel Use

(2013) Mette Charlot   ANNALS OF INTERNAL MEDICINE

Effect of esomeprazole versus famotidine on platelet inhibition by clopidogrel: A double-blind, randomized trial

(2011) Prabowo Tunggal et al.   AMERICAN HEART JOURNAL

Esomeprazole but Not Pantoprazole is Associated with Lower Plasma Concentrations of Clopidogrel's Active Metabolite

(2011) Ankie M Harmsze et al.   ANNALS OF PHARMACOTHERAPY

CYP2C19 But Not PON1 Genetic Variants Influence Clopidogrel Pharmacokinetics, Pharmacodynamics, and Clinical Efficacy in Post–Myocardial Infarction Patients

(2011) Jean-Sébastien Hulot et al.   Circulation-Cardiovascular Interventions

Effect of Paraoxonase-1 Polymorphism on Clinical Outcomes in Patients Treated With Clopidogrel After an Acute Myocardial Infarction

(2011) T Simon et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Paraoxonase 1 (PON1) Gene Variants Are Not Associated With Clopidogrel Response

(2011) J P Lewis et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

The Proton Pump Inhibitor, Omeprazole, but Not Lansoprazole or Pantoprazole, Is a Metabolism-Dependent Inhibitor of CYP2C19: Implications for Coadministration with Clopidogrel

(2011) B. W. Ogilvie et al.   DRUG METABOLISM AND DISPOSITION

Effects of Proton Pump Inhibitors on Platelet Function in Patients Receiving Clopidogrel

(2011) Chun Shing Kwok et al.   DRUG SAFETY

No association of paraoxonase-1 Q192R genotypes with platelet response to clopidogrel and risk of stent thrombosis after coronary stenting

(2011) D. Sibbing et al.   EUROPEAN HEART JOURNAL

Impact of proton pump inhibitors on efficacy of clopidogrel: Review of evidence

(2011) PrashantS Dalvi et al.   INDIAN JOURNAL OF PHARMACOLOGY

Clopidogrel and Proton Pump Inhibitors

(2011) Udaya S. Tantry et al.   JACC-Cardiovascular Interventions

Standard- vs High-Dose Clopidogrel Based on Platelet Function Testing After Percutaneous Coronary Intervention

(2011) Matthew J. Price   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

High Residual Platelet Reactivity After Clopidogrel Loading and Long-term Cardiovascular Events Among Patients With Acute Coronary Syndromes Undergoing PCI

(2011) Guido Parodi et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Clopidogrel–Drug Interactions

(2011) Eric R. Bates et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Influence of high-density lipoprotein and paraoxonase-1 on platelet reactivity in patients with acute coronary syndromes receiving clopidogrel therapy

(2011) A. D. TSELEPIS et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Genetic determinants of platelet response to clopidogrel

(2011) Aldona Kubica et al.   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

Genetic determinants of on-clopidogrel high platelet reactivity

(2011) Gianluca Campo et al.   PLATELETS

Cardiovascular Risk with Non-Steroidal Anti-Inflammatory Drugs: Systematic Review of Population-Based Controlled Observational Studies

(2011) Patricia McGettigan et al.   PLOS MEDICINE

Risk of recurrent myocardial infarction with the concomitant use of clopidogrel and proton pump inhibitors

(2010) V. E. Valkhoff et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Cardiovascular and Gastrointestinal Outcomes in Clopidogrel Users on Proton Pump Inhibitors: Results of a Large Dutch Cohort Study

(2010) Ofke S van Boxel et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Risk of Rehospitalization for Patients Using Clopidogrel With a Proton Pump Inhibitor

(2010) Karen M. Stockl   ARCHIVES OF INTERNAL MEDICINE

Proton Pump Inhibitors and Risk for Recurrent Clostridium difficile Infection

(2010) Amy Linsky   ARCHIVES OF INTERNAL MEDICINE

The potential interaction between clopidogrel and proton pump inhibitors: a systematic review

(2010) Joao Paulo de Aquino Lima et al.   BMC Medicine

Meta-analysis: Risk of fractures with acid-suppressing medication

(2010) Chun Shing Kwok et al.   BONE

Influences of different proton pump inhibitors on the anti-platelet function of clopidogrel in relation to CYP2C19 genotypes

(2010) Takahisa Furuta et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

ACCF/ACG/AHA 2010 Expert Consensus Document on the Concomitant Use of Proton Pump Inhibitors and Thienopyridines: A Focused Update of the ACCF/ACG/AHA 2008 Expert Consensus Document on Reducing the Gastrointestinal Risks of Antiplatelet Therapy and NSAID Use

(2010) et al.   CIRCULATION

Pharmacodynamic Effects of Concomitant Versus Staggered Clopidogrel and Omeprazole Intake

(2010) José L. Ferreiro et al.   Circulation-Cardiovascular Interventions

Differential Effects of Omeprazole and Pantoprazole on the Pharmacodynamics and Pharmacokinetics of Clopidogrel in Healthy Subjects: Randomized, Placebo-Controlled, Crossover Comparison Studies

(2010) D J Angiolillo et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Effects of Proton Pump Inhibitors on Adverse Gastrointestinal Events in Patients Receiving Clopidogrel

(2010) Chun Shing Kwok et al.   DRUG SAFETY

Histamine2-Receptor Antagonists Are an Alternative to Proton Pump Inhibitor in Patients Receiving Clopidogrel

(2010) Chun–Ying Wu et al.   GASTROENTEROLOGY

Esomeprazole With Clopidogrel Reduces Peptic Ulcer Recurrence, Compared With Clopidogrel Alone, in Patients With Atherosclerosis

(2010) Ping–I. Hsu et al.   GASTROENTEROLOGY

The Influence of Proton Pump Inhibitors on the Antiplatelet Potency of Clopidogrel Evaluated by 5 Different Platelet Function Tests

(2010) Thomas Gremmel et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Effect of proton pump inhibitors on clinical outcome in patients treated with clopidogrel: a systematic review and meta-analysis

(2010) J. M. SILLER-MATULA et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Genetic variants in ABCB1 and CYP2C19 and cardiovascular outcomes after treatment with clopidogrel and prasugrel in the TRITON–TIMI 38 trial: a pharmacogenetic analysis

(2010) Jessica L Mega et al.   LANCET

Paraoxonase-1 is a major determinant of clopidogrel efficacy

(2010) Heleen J Bouman et al.   NATURE MEDICINE

Clopidogrel with or without Omeprazole in Coronary Artery Disease

(2010) Deepak L. Bhatt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Impact of Proton Pump Inhibitors on the Effectiveness of Clopidogrel After Coronary Stent Placement: The Clopidogrel Medco Outcomes Study

(2010) Rolf P Kreutz et al.   PHARMACOTHERAPY

Identification of the Human Cytochrome P450 Enzymes Involved in the Two Oxidative Steps in the Bioactivation of Clopidogrel to Its Pharmacologically Active Metabolite

(2009) M. Kazui et al.   DRUG METABOLISM AND DISPOSITION

Gastrointestinal bleeding in high risk survivors of myocardial infarction: the VALIANT Trial

(2009) G. V. Moukarbel et al.   EUROPEAN HEART JOURNAL

Risk of Adverse Outcomes Associated With Concomitant Use of Clopidogrel and Proton Pump Inhibitors Following Acute Coronary Syndrome

(2009) P. Michael Ho   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Comparison of Omeprazole and Pantoprazole Influence on a High 150-mg Clopidogrel Maintenance Dose

(2009) Thomas Cuisset et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Genetic Determinants of Response to Clopidogrel and Cardiovascular Events

(2008) Tabassome Simon et al.   NEW ENGLAND JOURNAL OF MEDICINE