Drug disposition alterations in liver disease: extrahepatic effects in cholestasis and nonalcoholic steatohepatitis

CYP2B618492T→C Polymorphism Compromises Efavirenz Concentration in Coinfected HIV and Tuberculosis Patients CarryingCYP2B6Haplotype *1/*1

(2014) Weerawat Manosuthi et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Drug metabolism enzymes in a steatotic model of rat treated with a high fat diet and a low dose of streptozotocin

(2014) A. Vornoli et al.   FOOD AND CHEMICAL TOXICOLOGY

Synergistic interaction between genetics and disease on pravastatin disposition

(2014) John D. Clarke et al.   JOURNAL OF HEPATOLOGY

Hepatic bile acid metabolism and expression of cytochrome P450 and related enzymes are altered in Bsep −/− mice

(2014) Eugene Hrycay et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Association of ABCC2 −24C>T Polymorphism with High-Dose Methotrexate Plasma Concentrations and Toxicities in Childhood Acute Lymphoblastic Leukemia

(2014) Yan Liu et al.   PLoS One

ABCB1 1199G>A Genetic Polymorphism (Rs2229109) Influences the Intracellular Accumulation of Tacrolimus in HEK293 and K562 Recombinant Cell Lines

(2014) Géraldine Dessilly et al.   PLoS One

Decreased Renal Organic Anion Transporter 3 Expression in Type 1 Diabetic Rats

(2013) Arjinajarn Phatchawan et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Nonalcoholic fatty liver disease: an emerging threat to obese and diabetic individuals

(2013) Howard C. Masuoka et al.   Annals of the New York Academy of Sciences

Pharmacokinetics

(2013) Jianghong Fan et al.   BIOCHEMICAL PHARMACOLOGY

Nonalcoholic Fatty Liver Disease: Current Issues and Novel Treatment Approaches

(2013) Romina Lomonaco et al.   DRUGS

Low level of efavirenz in HIV-1-infected Thai adults is associated with the CYP2B6 polymorphism

(2013) C. Sukasem et al.   INFECTION

Evaluation of the relationship between polymorphisms inCYP2C8andCYP2C9and the pharmacokinetics of celecoxib

(2013) Rocío Prieto-Pérez et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation

(2013) Ulrich M. Zanger et al.   PHARMACOLOGY & THERAPEUTICS

Effects of 17α-ethynylestradiol-induced cholestasis on the pharmacokinetics of doxorubicin in rats: reduced biliary excretion and hepatic metabolism of doxorubicin

(2013) Young Hee Choi et al.   XENOBIOTICA

Experimental nonalcoholic fatty liver disease in mice leads to cytochrome p450 2a5 upregulation through nuclear factor erythroid 2-like 2 translocation

(2013) Yizhe Cui et al.   Redox Biology

Meta-Analysis of Cytochrome P450 2C19 Polymorphism and Risk of Adverse Clinical Outcomes Among Coronary Artery Disease Patients of Different Ethnic Groups Treated With Clopidogrel

(2012) Jae-Sik Jang et al.   AMERICAN JOURNAL OF CARDIOLOGY

Adverse Drug Reaction Deaths Reported in United States Vital Statistics, 1999-2006

(2012) G. Shepherd et al.   ANNALS OF PHARMACOTHERAPY

Impact of Genetic Variation in OATP Transporters to Drug Disposition and Response

(2012) Inna Y. Gong et al.   Drug Metabolism and Pharmacokinetics

Pharmacogenomics of drug-metabolizing enzymes: a recent update on clinical implications and endogenous effects

(2012) S C Sim et al.   PHARMACOGENOMICS JOURNAL

Bile Acids Induce Inflammatory Genes in Hepatocytes

(2011) Katryn Allen et al.   AMERICAN JOURNAL OF PATHOLOGY

Analysis of Global and Absorption, Distribution, Metabolism, and Elimination Gene Expression in the Progressive Stages of Human Nonalcoholic Fatty Liver Disease

(2011) A. D. Lake et al.   DRUG METABOLISM AND DISPOSITION

Variations in ATP-Binding Cassette Transporter Regulation during the Progression of Human Nonalcoholic Fatty Liver Disease

(2011) R. N. Hardwick et al.   DRUG METABOLISM AND DISPOSITION

Elevated hepatic multidrug resistance-associated protein 3/ATP-binding cassette subfamily C 3 expression in human obstructive cholestasis is mediated through tumor necrosis factor alpha and c-Jun NH2-terminal kinase/stress-activated protein kinase-signali

(2011) Jin Chai et al.   HEPATOLOGY

CYP2C19 Genotype, Clopidogrel Metabolism, Platelet Function, and Cardiovascular Events

(2011) Michael V. Holmes et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Changes of Organic Anion Transporter MRP4 and Related Nuclear Receptors in Human Obstructive Cholestasis

(2011) Jin Chai et al.   JOURNAL OF GASTROINTESTINAL SURGERY

Acetaminophen Pharmacokinetics in Children With Nonalcoholic Fatty Liver Disease

(2011) Nicole J Barshop et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Transcriptional Profiling of Human Liver Identifies Sex-Biased Genes Associated with Polygenic Dyslipidemia and Coronary Artery Disease

(2011) Yijing Zhang et al.   PLoS One

Adverse Drug Reactions: Part I

(2011) James M. Wooten   SOUTHERN MEDICAL JOURNAL

Pharmacokinetics of Vandetanib in Subjects with Renal or Hepatic Impairment

(2010) Angelika Weil et al.   CLINICAL PHARMACOKINETICS

Diversity in Antioxidant Response Enzymes in Progressive Stages of Human Nonalcoholic Fatty Liver Disease

(2010) R. N. Hardwick et al.   DRUG METABOLISM AND DISPOSITION

Elevated Systemic Elimination of Cimetidine in Rats with Acute Biliary Obstruction: The Role of Renal Organic Cation Transporter OCT2

(2010) Tomohiko Kurata et al.   Drug Metabolism and Pharmacokinetics

Influence of mild and moderate hepatic impairment on axitinib pharmacokinetics

(2010) Michael A. Tortorici et al.   INVESTIGATIONAL NEW DRUGS

Altered expression of MRP2, MRP3 and UGT2B1 in the liver affects the disposition of morphine and its glucuronide conjugate in a rat model of cholestasis

(2010) Yoshitaka Hasegawa et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Genotype–environment interactions and their translational implications

(2010) Tesfaye M Baye et al.   Personalized Medicine

Cytochrome P450 2C19*2 polymorphism and cardiovascular recurrences in patients taking clopidogrel: a meta-analysis

(2010) F Sofi et al.   PHARMACOGENOMICS JOURNAL

Xenobiotic, Bile Acid, and Cholesterol Transporters: Function and Regulation

(2010) C. D. Klaassen et al.   PHARMACOLOGICAL REVIEWS

New diagnostic and treatment approaches in non-alcoholic fatty liver disease (NAFLD)

(2009) Rafeeq Ali et al.   ANNALS OF MEDICINE

Nrf2 counteracts cholestatic liver injury via stimulation of hepatic defense systems

(2009) Kosuke Okada et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Alteration of Methotrexate Biliary and Renal Elimination during Extrahepatic and Intrahepatic Cholestasis in Rats

(2009) Eva Brcakova et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Altered Expression of Nuclear Receptors Affects the Expression of Metabolic Enzymes and Transporters in a Rat Model of Cholestasis

(2009) Yoshitaka Hasegawa et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Experimental non-alcoholic fatty liver disease results in decreased hepatic uptake transporter expression and function in rats

(2009) Craig D. Fisher et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Characterization of the Mechanisms Involved in the Increased Renal Elimination of Bromosulfophthalein During Cholestasis: Involvement of Oatp1

(2009) Anabel Brandoni et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

ANIT-Induced Intrahepatic Cholestasis Alters Hepatobiliary Transporter Expression via Nrf2-Dependent and Independent Signaling

(2009) Yuji Tanaka et al.   TOXICOLOGICAL SCIENCES

Drug metabolizing enzyme induction pathways in experimental non-alcoholic steatohepatitis

(2008) Craig D. Fisher et al.   ARCHIVES OF TOXICOLOGY

Developmental Changes in Human Liver CYP2D6 Expression

(2008) J. C. Stevens et al.   DRUG METABOLISM AND DISPOSITION

Cytochrome P450 2C19 polymorphism in young patients treated with clopidogrel after myocardial infarction: a cohort study

(2008) Jean-Philippe Collet et al.   LANCET

Drug-Metabolizing Enzyme and Transporter Expression in a Mouse Model of Diabetes and Obesity

(2008) Qiuqiong Cheng et al.   MOLECULAR PHARMACEUTICS

Genetic Determinants of Response to Clopidogrel and Cardiovascular Events

(2008) Tabassome Simon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Expression of Hepatocyte Transporters and Nuclear Receptors in Children With Early and Late-Stage Biliary Atresia

(2008) Huey-Ling Chen et al.   PEDIATRIC RESEARCH

Reduced Antidiabetic Effect of Metformin and Down-regulation of Hepatic Oct1 in Rats with Ethynylestradiol-Induced Cholestasis

(2008) Hyo-Eon Jin et al.   PHARMACEUTICAL RESEARCH

Nrf2- and PPARα-Mediated Regulation of Hepatic Mrp Transporters after Exposure to Perfluorooctanoic Acid and Perfluorodecanoic Acid

(2008) Jonathan M. Maher et al.   TOXICOLOGICAL SCIENCES

Effect of biliary obstruction and internal biliary drainage on hepatic cytochrome P450 isozymes in rats

(2008) Shintaro Fukushima et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Induction of Mrp3 and Mrp4 transporters during acetaminophen hepatotoxicity is dependent on Nrf2

(2007) Lauren M. Aleksunes et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY