A mouse with humanized liver as an animal model for predicting drug effects and for studying hepatic viral infection: where to next?

Development of Liposomal Anticancer Drugs

(2013) Kenji Hyodo et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Paradigm Shift in Toxicity Testing and Modeling

(2012) Hongmao Sun et al.   AAPS Journal

Severe necroinflammatory reaction caused by natural killer cell-mediated Fas/Fas ligand interaction and dendritic cells in human hepatocyte chimeric mouse

(2012) Akihito Okazaki et al.   HEPATOLOGY

Generation of metabolically functioning hepatocytes from human pluripotent stem cells by FOXA2 and HNF1α transduction

(2012) Kazuo Takayama et al.   JOURNAL OF HEPATOLOGY

Morphological and microarray analyses of human hepatocytes from xenogeneic host livers

(2012) Chise Tateno et al.   LABORATORY INVESTIGATION

Modeling hepatitis C virus infection using human induced pluripotent stem cells

(2012) R. E. Schwartz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Generation and Characterization of Severe Combined Immunodeficiency Rats

(2012) Tomoji Mashimo et al.   Cell Reports

Productive Hepatitis C Virus Infection of Stem Cell-Derived Hepatocytes Reveals a Critical Transition to Viral Permissiveness during Differentiation

(2012) Xianfang Wu et al.   PLoS Pathogens

Significant Species Difference in Amide Hydrolysis of GDC-0834, a Novel Potent and Selective Bruton's Tyrosine Kinase Inhibitor

(2011) L. Liu et al.   DRUG METABOLISM AND DISPOSITION

Increasing recognition of the importance of aldehyde oxidase in drug development and discovery

(2011) Enrico Garattini et al.   DRUG METABOLISM REVIEWS

A Humanized Mouse Model to Study Hepatitis C Virus Infection, Immune Response, and Liver Disease

(2011) Michael L. Washburn et al.   GASTROENTEROLOGY

Rapid emergence of telaprevir resistant hepatitis C virus strain from wildtype clone in vivo

(2011) Nobuhiko Hiraga et al.   HEPATOLOGY

Hepatitis C virus induces interferon-λ and interferon-stimulated genes in primary liver cultures

(2011) Svetlana Marukian et al.   HEPATOLOGY

A first step towards a mouse model for hepatitis C virus infection containing a human immune system

(2011) Eric Robinet et al.   JOURNAL OF HEPATOLOGY

Antiarthritis Effect of a Novel Bruton's Tyrosine Kinase (BTK) Inhibitor in Rat Collagen-Induced Arthritis and Mechanism-Based Pharmacokinetic/Pharmacodynamic Modeling: Relationships between Inhibition of BTK Phosphorylation and Efficacy

(2011) L. Liu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Inducible Apoptosis as a Safety Switch for Adoptive Cell Therapy

(2011) Antonio Di Stasi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hepatitis C Virus Infection Suppresses the Interferon Response in the Liver of the Human Hepatocyte Chimeric Mouse

(2011) Masataka Tsuge et al.   PLoS One

Tissue Distribution and Gender-Divergent Expression of 78 Cytochrome P450 mRNAs in Mice

(2011) Helen J. Renaud et al.   TOXICOLOGICAL SCIENCES

Case report of extensive metabolism by aldehyde oxidase in humans: Pharmacokinetics and metabolite profile of FK3453 in rats, dogs, and humans

(2011) Takafumi Akabane et al.   XENOBIOTICA

Evaluation of the pharmacokinetics, biotransformation and hepatic transporter effects of troglitazone in mice with humanized livers

(2011) Timothy Schulz-Utermoehl et al.   XENOBIOTICA

Hepatic Hyperplasia Associated with Discordant Xenogeneic Parenchymal-Nonparenchymal Interactions in Human Hepatocyte-Repopulated Mice

(2010) Rie Utoh et al.   AMERICAN JOURNAL OF PATHOLOGY

Liver Xeno-Repopulation with Human Hepatocytes in Fah−/−Rag2−/− Mice after Pharmacological Immunosuppression

(2010) Zhiying He et al.   AMERICAN JOURNAL OF PATHOLOGY

Drug-metabolizing enzyme, transporter, and nuclear receptor genetically modified mouse models

(2010) Xi-Ling Jiang et al.   DRUG METABOLISM REVIEWS

Induced pluripotent stem cell–derived hepatocytes have the functional and proliferative capabilities needed for liver regeneration in mice

(2010) Silvia Espejel et al.   JOURNAL OF CLINICAL INVESTIGATION

Human liver chimeric mice provide a model for hepatitis B and C virus infection and treatment

(2010) Karl-Dimiter Bissig et al.   JOURNAL OF CLINICAL INVESTIGATION

Practical evaluation of a mouse with chimeric human liver model for hepatitis C virus infection using an NS3-4A protease inhibitor

(2010) N. Kamiya et al.   JOURNAL OF GENERAL VIROLOGY

ME3738 enhances the effect of interferon and inhibits hepatitis C virus replication both in vitro and in vivo

(2010) Hiromi Abe et al.   JOURNAL OF HEPATOLOGY

Elimination of hepatitis C virus by short term NS3-4A and NS5B inhibitor combination therapy in human hepatocyte chimeric mice

(2010) Eiji Ohara et al.   JOURNAL OF HEPATOLOGY

Aldehyde Oxidase: An Enzyme of Emerging Importance in Drug Discovery

(2010) David C. Pryde et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Mouse Model of Inducible Liver Injury Caused by Tet-On Regulated Urokinase for Studies of Hepatocyte Transplantation

(2009) Xijun Song et al.   AMERICAN JOURNAL OF PATHOLOGY

Humanized Mice for Modeling Human Infectious Disease: Challenges, Progress, and Outlook

(2009) Nicolas Legrand et al.   Cell Host & Microbe

Humanized Animal Models to Study Drug Metabolism: No Longer a "Chimera"?

(2009) F. Botre   CLINICAL CHEMISTRY

uPA+/+-SCID Mouse with Humanized Liver as a Model for In Vivo Metabolism of Exogenous Steroids: Methandienone as a Case Study

(2009) L. Lootens et al.   CLINICAL CHEMISTRY

The uPA(+/+)-SCID Mouse with Humanized Liver as a Model for in Vivo Metabolism of 4-Androstene-3,17-dione

(2009) L. Lootens et al.   DRUG METABOLISM AND DISPOSITION

Bruton's tyrosine kinase as a drug discovery target

(2009) Z. Pan   DRUG NEWS & PERSPECTIVES

Towards a small animal model for hepatitis C

(2009) Alexander Ploss et al.   EMBO REPORTS

In vivomodeling of human liver for pharmacological study using humanized mouse

(2009) Katsutoshi Yoshizato et al.   Expert Opinion on Drug Metabolism & Toxicology

Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells

(2009) Karim Si-Tayeb et al.   HEPATOLOGY

Knockout Rats via Embryo Microinjection of Zinc-Finger Nucleases

(2009) Aron M. Geurts et al.   SCIENCE

A Human Hepatocyte-Bearing Mouse: An Animal Model to Predict Drug Metabolism and Effectiveness in Humans

(2009) Katsutoshi Yoshizato et al.   PPAR Research

Establishment of a humanized model of liver using NOD/Shi- scid IL2Rg null mice

(2008) Hiroshi Suemizu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Rescue of Fertility in Homozygous Mice for the Urokinase Plasminogen Activator Transgene by the Transplantation of Mouse Hepatocytes

(2008) Nicolas M. Brezillon et al.   CELL TRANSPLANTATION

Mice as Clinically Relevant Models for the Study of Cytochrome P450-dependent Metabolism

(2008) S Muruganandan et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Establishment of an infectious genotype 1b hepatitis C virus clone in human hepatocyte chimeric mice

(2008) T. Kimura et al.   JOURNAL OF GENERAL VIROLOGY