Bioluminescent assays for ADME evaluation: dialing in CYP selectivity with luminogenic substrates

Proluciferin Acetals as Bioluminogenic Substrates for Cytochrome P450 Activity and Probes for CYP3A Inhibition

(2011) P. L. Meisenheimer et al.   DRUG METABOLISM AND DISPOSITION

A Comparison of Whole Genome Gene Expression Profiles of HepaRG Cells and HepG2 Cells to Primary Human Hepatocytes and Human Liver Tissues

(2010) S. N. Hart et al.   DRUG METABOLISM AND DISPOSITION

Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver

(2010) X. Yang et al.   GENOME RESEARCH

HepaRG human hepatic cell line utility as a surrogate for primary human hepatocytes in drug metabolism assessment in vitro

(2010) Marc Lübberstedt et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Cataloging the Repertoire of Nature's Blowtorch, P450

(2009) F. Peter Guengerich   CHEMISTRY & BIOLOGY

Evaluation of Luciferin-Isopropyl Acetal as a CYP3A4 Substrate for Human Hepatocytes: Effects of Organic Solvents, Cytochrome P450 (P450) Inhibitors, and P450 Inducers

(2009) A. P. Li   DRUG METABOLISM AND DISPOSITION

Comprehensive characterization of cytochrome P450 isozyme selectivity across chemical libraries

(2009) Henrike Veith et al.   NATURE BIOTECHNOLOGY

Stem cell-derived hepatocytes and their use in toxicology

(2009) Christiane Guguen-Guillouzo et al.   TOXICOLOGY

In vitromodel for the prediction of clinical CYP3A4 induction using HepaRG cells

(2009) A. Kaneko et al.   XENOBIOTICA