Have physiologically-based pharmacokinetic models delivered?

Physiologically-Based Pharmacokinetics in Drug Development and Regulatory Science

(2011) Malcolm Rowland et al.   Annual Review of Pharmacology and Toxicology

Role of modeling and simulation in pediatric investigation plans

(2011) Efthymios Manolis et al.   PEDIATRIC ANESTHESIA

Risk Assessment in Extrapolation of Pharmacokinetics from Preclinical Data to Humans

(2010) Zvi Teitelbaum et al.   CLINICAL PHARMACOKINETICS

Applications of Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation During Regulatory Review

(2010) P Zhao et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Exploratory population pharmacokinetics (e-PPK) analysis for predicting human PK using exploratory ADME data during early drug discovery research

(2010) Kenji Tabata et al.   EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

Physiologically based pharmacokinetic (PBPK) tool kit for environmental pollutants – metals

(2010) P. Ruiz et al.   SAR AND QSAR IN ENVIRONMENTAL RESEARCH

Drug interactions evaluation: An integrated part of risk assessment of therapeutics

(2010) Lei Zhang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

A unified algorithm for predicting partition coefficients for PBPK modeling of drugs and environmental chemicals

(2010) Thomas Peyret et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

A hybrid approach to advancing quantitative prediction of tissue distribution of basic drugs in human

(2010) Patrick Poulin et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Modelling and PBPK Simulation in Drug Discovery

(2009) Hannah M. Jones et al.   AAPS Journal

Proposals for model-based paediatric medicinal development within the current European Union regulatory framework

(2009) Efthymios Manolis et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Drug–drug interaction predictions with PBPK models and optimal multiresponse sampling time designs: application to midazolam and a phase I compound. Part 1: comparison of uniresponse and multiresponse designs using PopDes

(2009) Marylore Chenel et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Drug–drug interaction predictions with PBPK models and optimal multiresponse sampling time designs: application to midazolam and a phase I compound. Part 2: clinical trial results

(2009) Marylore Chenel et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Prediction of Phase I single-dose pharmacokinetics using recombinant cytochromes P450 and physiologically based modelling

(2009) C. R. Gibson et al.   XENOBIOTICA

Physiology-Based Simulations of a Pathological Condition

(2008) Andrea N Edginton et al.   CLINICAL PHARMACOKINETICS

Whole body physiologically-based pharmacokinetic models: their use in clinical drug development

(2008) Andrea N Edginton et al.   Expert Opinion on Drug Metabolism & Toxicology

Pharmacometrics: A Multidisciplinary Field to Facilitate Critical Thinking in Drug Development and Translational Research Settings

(2008) Jeffrey S. Barrett et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Pre-clinical pharmacokinetics of UK-453,061, a novel non-nucleoside reverse transcriptase inhibitor (NNRTI), and use ofin silicophysiologically based prediction tools to predict the oral pharmacokinetics of UK-453,061 in man

(2008) G. Allan et al.   XENOBIOTICA