Mechanistic enhancement of the intestinal absorption of drugs containing the polar guanidino functionality

Novel influenza A(H1N1) 2009 in vitro reassortant viruses with oseltamivir resistance

(2010) Michèle Ottmann et al.   ANTIVIRAL THERAPY

Specificity of a Prodrug-Activating Enzyme hVACVase: The Leaving Group Effect

(2010) Jing Sun et al.   MOLECULAR PHARMACEUTICS

Enabling the Intestinal Absorption of Highly Polar Antiviral Agents: Ion-Pair Facilitated Membrane Permeation of Zanamivir Heptyl Ester and Guanidino Oseltamivir

(2010) Jonathan M. Miller et al.   MOLECULAR PHARMACEUTICS

High-Permeability Criterion for BCS Classification: Segmental/pH Dependent Permeability Considerations

(2010) Arik Dahan et al.   MOLECULAR PHARMACEUTICS

Permissive Secondary Mutations Enable the Evolution of Influenza Oseltamivir Resistance

(2010) J. D. Bloom et al.   SCIENCE

Floating Controlled Drug Delivery System of Famotidine Loaded Hollow Microspheres (Microballoons) in the Stomach

(2010) S. Ramachandran et al.   Current Drug Delivery

The H2 Receptor Antagonist Nizatidine is a P-Glycoprotein Substrate: Characterization of its Intestinal Epithelial Cell Efflux Transport

(2009) Arik Dahan et al.   AAPS Journal

Small intestinal efflux mediated by MRP2 and BCRP shifts sulfasalazine intestinal permeability from high to low, enabling its colonic targeting

(2009) Arik Dahan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Current Prodrug Design for Drug Discovery

(2009) Pei-Wen Hsieh et al.   CURRENT PHARMACEUTICAL DESIGN

Current advances in research and clinical applications of PLGA-based nanotechnology

(2009) Jian-Ming Lü et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

A novel gastric-resident osmotic pump tablet: In vitro and in vivo evaluation

(2009) Jin Guan et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

MRP2 mediated drug–drug interaction: Indomethacin increases sulfasalazine absorption in the small intestine, potentially decreasing its colonic targeting

(2009) Arik Dahan et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Quasi-equilibrium analysis of the ion-pair mediated membrane transport of low-permeability drugs

(2009) Jonathan M. Miller et al.   JOURNAL OF CONTROLLED RELEASE

The First Bioreversible Prodrug of Metformin with Improved Lipophilicity and Enhanced Intestinal Absorption

(2009) Kristiina M. Huttunen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Enhancing the Intestinal Absorption of Molecules Containing the Polar Guanidino Functionality: A Double-Targeted Prodrug Approach

(2009) Jing Sun et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Novel Gastro-Retentive Osmotic Pump Capsule Using Asymmetric Membrane Technology: In Vitro and In Vivo Evaluation

(2009) Jin Guan et al.   PHARMACEUTICAL RESEARCH

Guanidino Compounds as Uremic (Neuro)Toxins

(2009) Peter Paul De Deyn et al.   SEMINARS IN DIALYSIS

Release Mechanisms Behind Polysaccharides-Based Famotidine Controlled Release Matrix Tablets

(2008) Enas M. Elmowafy et al.   AAPS PHARMSCITECH

Optimization Studies on Floating Multiparticulate Gastroretentive Drug Delivery System of Famotidine

(2008) Reshu Gupta et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Novel linear triaryl guanidines, N-substituted guanidines and potential prodrugs as antiprotozoal agents

(2008) Reem K. Arafa et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Segmental-dependent membrane permeability along the intestine following oral drug administration: Evaluation of a triple single-pass intestinal perfusion (TSPIP) approach in the rat

(2008) Arik Dahan et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Preparation of aminoglycoside-loaded chitosan nanoparticles using dextran sulphate as a counterion

(2008) Enxian Lu et al.   JOURNAL OF MICROENCAPSULATION

Pharmaceutical and pharmacological importance of peptide transporters

(2008) Matthias Brandsch et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Segmental Dependent Transport of Low Permeability Compounds along the Small Intestine Due to P-Glycoprotein: The Role of Efflux Transport in the Oral Absorption of BCS Class III Drugs

(2008) Arik Dahan et al.   MOLECULAR PHARMACEUTICS

The chemistry and biology of organic guanidine derivatives

(2008) Roberto G. S. Berlinck et al.   NATURAL PRODUCT REPORTS

Grapefruit Juice and its Constituents Augment Colchicine Intestinal Absorption: Potential Hazardous Interaction and the Role of P-Glycoprotein

(2008) Arik Dahan et al.   PHARMACEUTICAL RESEARCH

Amino Acid Transport Across Mammalian Intestinal and Renal Epithelia

(2008) Stefan Bröer   PHYSIOLOGICAL REVIEWS

Towards Metformin Prodrugs

(2008) Kristiina Huttunen et al.   SYNTHESIS-STUTTGART