ABCG2: the key to chemoresistance in cancer stem cells?

Nilotinib (AMN107, Tasigna ® ) reverses multidrug resistance by inhibiting the activity of the ABCB1/Pgp and ABCG2/BCRP/MXR transporters

(2009) Amit K. Tiwari et al.   BIOCHEMICAL PHARMACOLOGY

Chemoresistant Colorectal Cancer Cells, the Cancer Stem Cell Phenotype, and Increased Sensitivity to Insulin-like Growth Factor-I Receptor Inhibition

(2009) N. A. Dallas et al.   CANCER RESEARCH

PTEN/PI3K/Akt Pathway Regulates the Side Population Phenotype and ABCG2 Activity in Glioma Tumor Stem-like Cells

(2009) Anne-Marie Bleau et al.   Cell Stem Cell

Tyrosine Kinase Inhibitors – A Review on Pharmacology, Metabolism and Side Effects

(2009) Jorg Hartmann et al.   CURRENT DRUG METABOLISM

Regulation of PI(3)K/Akt signalling and cellular transformation by inositol polyphosphate 4-phosphatase-1

(2009) Ivan Ivetac et al.   EMBO REPORTS

Lack of association between ABCB1, ABCG2, and ABCC2 genetic polymorphisms and multidrug resistance in partial epilepsy

(2009) Dong Wook Kim et al.   EPILEPSY RESEARCH

Gefitinib (Iressa) Potentiates the Effect of Ionizing Radiation in Thyroid Cancer Cell Lines

(2009) Jay Patrick Lopez et al.   LARYNGOSCOPE

MicroRNA-328 Negatively Regulates the Expression of Breast Cancer Resistance Protein (BCRP/ABCG2) in Human Cancer Cells

(2009) Y.-Z. Pan et al.   MOLECULAR PHARMACOLOGY

Imatinib-Mediated Inactivation of Akt Regulates ABCG2 Function in Head and Neck Squamous Cell Carcinoma

(2008) Theresa S. Chu et al.   ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY

Suspension culture combined with chemotherapeutic agents for sorting of breast cancer stem cells

(2008) Hai-zhi Li et al.   BMC CANCER

Side population cells in human cancers

(2008) Colleen Wu et al.   CANCER LETTERS

ABCG2 Expression and Side Population Abundance Regulated by a Transforming Growth Factor  -Directed Epithelial-Mesenchymal Transition

(2008) L. Yin et al.   CANCER RESEARCH

Analysis of ABCG2 expression and side population identifies intrinsic drug efflux in the HCC cell line MHCC-97L and its modulation by Akt signaling

(2008) Chen Hu et al.   CARCINOGENESIS

Akt as a therapeutic target in cancer

(2008) Linda S Steelman et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Is ATP binding responsible for initiating drug translocation by the multidrug transporter ABCG2?

(2008) Christopher A. McDevitt et al.   FEBS Journal

Folate deprivation induces BCRP (ABCG2) expression and mitoxantrone resistance in Caco-2 cells

(2008) Clara Lemos et al.   INTERNATIONAL JOURNAL OF CANCER

Polymorphisms inABCG2,ABCC3andCNT1genes and their possible impact on chemotherapy outcome of lung cancer patients

(2008) Phillip J. Müller et al.   INTERNATIONAL JOURNAL OF CANCER

Cancer Stem Cells in Head and Neck Squamous Cell Cancer

(2008) Mark E.P. Prince et al.   JOURNAL OF CLINICAL ONCOLOGY

Contributions of the Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways to leukemia

(2008) L S Steelman et al.   LEUKEMIA

Regulation of ABCG2 Expression at the 3' Untranslated Region of Its mRNA through Modulation of Transcript Stability and Protein Translation by a Putative MicroRNA in the S1 Colon Cancer Cell Line

(2008) K. K. W. To et al.   MOLECULAR AND CELLULAR BIOLOGY

Histone Modifications at the ABCG2 Promoter following Treatment with Histone Deacetylase Inhibitor Mirror Those in Multidrug-Resistant Cells

(2008) K. K.W. To et al.   MOLECULAR CANCER RESEARCH

HER2 regulates the mammary stem/progenitor cell population driving tumorigenesis and invasion

(2008) H Korkaya et al.   ONCOGENE

Detection and Characterization of CD133+ Cancer Stem Cells in Human Solid Tumours

(2008) Virginia Tirino et al.   PLoS One

Porphyrin Homeostasis Maintained by ABCG2 Regulates Self-Renewal of Embryonic Stem Cells

(2008) Jimmy Susanto et al.   PLoS One