Article
Biochemistry & Molecular Biology
Meng Wang, Lei Zhang, Hao Yue, Weizhen Cai, Haowen Yin, Yingying Tian, Ping Dong, Jingfeng Wang
Summary: This study investigated the hepatoprotective effects of peptides from Antarctic krill (AKP) on carbon tetrachloride (CCl4)-induced acute liver injury (ALI) in mice and found that AKP pretreatment significantly attenuated CCl4-induced liver injury. This protective effect was associated with the activation of the Nrf2/HO-1 pathway and the improvement of redox balance.
Article
Plant Sciences
Siqiniseko S. Ndlovu, Anil A. Chuturgoon, Terisha Ghazi
Summary: The World Health Organization (WHO) reported that there are 37 million individuals living with HIV worldwide, with the majority in South Africa. This study investigated the toxicity of ARV drugs on mitochondria and the NRF2 antioxidant pathway and its possible amelioration using Moringa oleifera Lam (MO) leaf extracts.
Review
Toxicology
Marta Justyna Koziel, Karolina Kowalska, Agnieszka Wanda Piastowska-Ciesielska
Summary: Nrf2 is a crucial transcription factor involved in cellular response to oxidative stress, regulating the expression of antioxidant enzymes to remove free radicals. Its increased expression in cancer cells suggests its tissue-specific role. Additionally, Nrf2 may play an important role in response to environmental factors such as mycotoxins.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hyeongyeong Kim, Hyung Joo Suh, Ki-Bae Hong, Eun-Jin Jung, Yejin Ahn
Summary: The protective effects of a mixture of cysteine and glutathione against ethanol-induced hangover and liver damage were investigated. The mixture improved alcohol-induced behavior and enhanced ethanol-metabolizing enzyme activity. It also reduced the levels of serum alcohol and acetaldehyde, and regulated the expression of antioxidant enzymes through the Nrf2 pathway.
Article
Pharmacology & Pharmacy
Veronica F. Salau, Ochuko L. Erukainure, Kolawole A. Olofinsan, Recardia L. S. Schoeman, Motlalepula G. Matsabisa
Summary: The study investigated the hepatoprotective effect of Lippia javanica herbal tea in Fe2+-mediated hepatic oxidative injury. Results showed that the infusion has strong antioxidant activity and hepatoprotective effects. It increased the levels of reduced glutathione, non-protein thiol, superoxide dismutase, and catalase, while reducing hepatic malondialdehyde levels and several enzyme activities. The infusion contains phytoconstituents such as phenolic compounds, tannins, phenolic glycosides, and terpenoids. Molecular docking analysis revealed the potential binding affinity of dihydroroseoside and obacunone with antioxidant enzymes. Overall, the study highlights the potential therapeutic use of L. javanica herbal tea in oxidative stress-related liver diseases.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Qian Zhou, Lanxiang Wang, Bin Liu, Jianbo Xiao, Ka-Wing Cheng, Feng Chen, Mingfu Wang
Summary: The extract of rose flower shows significant anti-alcohol and hepatoprotective effects by partially reducing ethanol-induced cell apoptosis through the activation of the AMPK/SIRT1 signaling pathway. A specific component, N1,N5,N10-(E)-tri-p-coumaroylspermidine, in this extract exhibits remarkable hepatoprotective activity.
Article
Biochemistry & Molecular Biology
Raja Rezgui, Ruhi Walia, Jyoti Sharma, Dwinder Sidhu, Khalid Alshagadali, Saumya Ray Chaudhuri, Amir Saeed, Priyankar Dey
Summary: This study demonstrates that the metabolites from Lactobacillus plantarum (LPM), a probiotic bacterium, can protect HepG2 cells against oxidative damage induced by H2O2. The cytoprotective effects of LPM are likely mediated by an Nrf2-dependent mechanism.
Article
Biochemistry & Molecular Biology
Sarah Tauber, Maria Katharina Sieckmann, Katrin Erler, Wilhelm Stahl, Lars-Oliver Klotz, Holger Steinbrenner
Summary: The study found that the Se status had no major effect on Nrf2 signaling in HepG2 cells, although electrophiles could enhance the expression of Nrf2 target genes independent of cellular Se status.
Article
Nutrition & Dietetics
Huong Thi Lan Nguyen, Stefan Kasapis, Nitin Mantri
Summary: The study compared the effects of Manuka honey and newly developed honeys on oxidative stress and cholesterol homeostasis, showing that Arjuna, Guggul, and Manuka honeys had significant antioxidant activities and reduced total cholesterol levels, while Jiaogulan honey exhibited the most cytotoxic effects.
Article
Pharmacology & Pharmacy
V. H. Amstutz, A. Cengo, F. Gehres, D. T. H. M. Sijm, M. F. Vrolijk
Summary: This study investigated the structure-activity relationship between per- and polyfluoroalkyl substances (PFAS) and hepatotoxicity. The results showed that the carbon chain-length and functional head-group of PFAS determine their toxicity, providing the possibility of developing a predictive model for risk assessment.
Article
Biochemistry & Molecular Biology
Lujia Zhang, Liuqing Yang, Yinghua Luo, Li Dong, Fang Chen
Summary: This review summarizes the recent advances in the mechanism of hepatotoxicity through AA-induced oxidative stress in rodent livers and hepatic cell lines, which is beneficial for assessing the risks of AA exposure and exploring effective intervention methods for AA hepatotoxicity.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Pharmacology & Pharmacy
Xianchou Xu, Qingbo Liu, Jiahao Li, Mengjie Xiao, Ting Gao, Xiaohui Zhang, Guangping Lu, Jie Wang, Yuanfang Guo, Peinan Wen, Junlian Gu
Summary: The study demonstrated that co-treatment with RES and FGF1 significantly inhibited DOX-induced hepatic inflammation and apoptosis, while also markedly suppressing DOX-induced hepatic oxidative stress via targeting the AMPK/NRF2 pathway. This combination may provide a new therapeutic strategy for limiting DOX-induced hepatotoxicity.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Laiyu Zhu, Xiaoye Fan, Chunyuan Cao, Kailiang Li, Wenli Hou, Xinxin Ci
Summary: This study found that xanthohumol can exert hepatoprotective effects by inhibiting oxidative stress and mitochondrial dysfunction, and triggering the activation of Nrf2 through the AMPK/Akt/GSK3β/Nrf2 antioxidant pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Food Science & Technology
Qingfeng He, Yunjing Luo, Ziqi Xie
Summary: This study demonstrated the antioxidant and anti-inflammatory effects of SFN against Cd-induced liver damage, which were associated with the modulation of the intrinsic Nrf2/ARE and NF-kappa B pathway.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Biochemistry & Molecular Biology
Chiharuko Ushimoto, Shigeru Sugiki, Kenshirou Kunii, Shinya Inoue, Eriko Kuroda, Ryoko Akai, Takao Iwawaki, Katsuhito Miyazawa
Summary: Oxidative stress is a significant risk factor for calcium oxalate nephrolithiasis. This study investigates the association between oxidative stress response and stone formation through analyzing the response during different phases and observing the effect on crystal formation in mouse models. The findings suggest that the oxidative stress response via Keap1-Nrf2 pathway may contribute to crystal formation and could be a potential target for preventing and treating nephrolithiasis.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)