Article
Chemistry, Physical
Shiyu Wei, Yafei Liu, Jieyu Zhou, Guochao Xu, Ye Ni
Summary: Two enantiocomplementary Baeyer-Villiger monooxygenases, RaBVMO and AmBVMO, have been identified for asymmetric sulfoxidation with optimal pH of 9.0 and temperature of 35 degrees C. Both enzymes exhibit broad substrate spectrum and high catalytic efficiency, showing potential application in asymmetric synthesis of sulfoxides.
MOLECULAR CATALYSIS
(2021)
Article
Environmental Sciences
Xifa Yang, Yuhao He, Bin Liu, Hui Guo, Lu Xue, Yiwen Duan, Hao Hu, Fei Gao, Lin Zhou, Jing Jing Zhang
Summary: The study showed that alfalfa has a certain tolerance to ATZ and is capable of accumulating the compound. Analysis using metabolomic and transcriptomic techniques revealed significant changes in specific genes and metabolites of alfalfa under ATZ stress, providing potential pathways for using alfalfa as an engineering plant to remediate ATZ-contaminated soil.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Review
Environmental Sciences
Fang-Fang Zhao, Xiao-Li Wang, Ya-Ting Lei, Hong-Qiu Li, Zhi-Ming Li, Xiao-Xiao Hao, Wei-Wei Ma, Yong-Hui Wu, Sheng-Yuan Wang
Summary: Acrylamide, a neurotoxic and carcinogenic compound, is widely present in fried foods and cigarettes. Its intake assessment through dietary questionnaires is limited due to confounding factors. This review focuses on the levels of AAMA, a urinary metabolite of acrylamide in humans, its association with diseases, and research gaps and future needs. Studies from eight countries showed higher urinary AAMA levels in smokers and children, with the highest levels found in the population from Spain. AAMA is associated with various diseases, especially cardiovascular diseases, making it an important biomarker for internal acrylamide exposure and setting allowable intake in foods.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Chryssostomos Chatgilialoglu, Magdalena Grzelak, Konrad Skotnicki, Piotr Filipiak, Franciszek Kazmierczak, Gordon L. Hug, Krzysztof Bobrowski, Bronislaw Marciniak
Summary: In this study, the complex reaction of hydroxyl radicals with methionine residues in peptides and proteins was investigated using ionizing radiation and pulse radiolysis techniques. The results revealed that the reaction mechanism depends on the distance between the sulfur atom and the peptide backbone, leading to the formation of different transient species and final products.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Oladipupo A. Aregbesola, Ajit Kumar, Mduduzi P. Mokoena, Ademola O. Olaniran
Summary: The pentachlorophenol degrading bacterium BtAOA was isolated from effluent of a wastewater treatment plant in Durban, South Africa. The whole-genome sequencing and metabolic reconstruction revealed that enzymes involved in the PCP degradation pathway of BtAOA were acquired through horizontal gene transfer and from pre-existing enzymes in related subsystems.
FUNCTIONAL & INTEGRATIVE GENOMICS
(2021)
Review
Pharmacology & Pharmacy
Glyn B. Steventon, Stephen C. Mitchell
Summary: S-Carboxymethyl-l-cysteine is a mucolytic agent used in the treatment of respiratory disorders, with multiple dose modeling indicating effective concentrations ranging from 1.30 to 8.40 μg/mL in the clinical setting. Pharmacodynamic studies reporting significant effects below approximately 10 μg/mL may occur in vivo, mainly through gene-related mechanisms. However, most events requiring levels much higher than achievable in clinical situations were only demonstrable in vitro.
Article
Pharmacology & Pharmacy
Lamia Chorfi, Azzedine Fercha, Faouzia Derouiche, Fatima Zohra Sebihi, Dallal Houhou, Keltoum Chorfi, Katia Bendjemana
Summary: This study investigated the potential association of genetic polymorphisms of GSTM1, GSTT1, and NAT2 genes and epidemiological parameters with the risk of HCC in the Algerian population. The results showed that the GSTM1 null and NAT2 slow acetylator genotypes are associated with an increased risk of HCC, particularly in smokers. No significant association was found for the GSTT1 null genotype in the contribution to HCC risk.
Article
Pharmacology & Pharmacy
Panayotis Panagopoulos, Stephen C. Mitchell, Glyn B. Steventon
Article
Pharmacology & Pharmacy
Evita Vandenbossche, Christopher Lucas, Lata Mistry, Emma Garfield, Stephen C. Mitchell, Glyn B. Steventon
Article
Oncology
U. Keilholz, L. Rohde, P. Mehlitz, M. Knoedler, A. Schmittel, V. Kuemmerlen, K. Klinghammer, P. Treasure, M. Lassus, G. Steventon, M. Machacek, N. Utku
EUROPEAN JOURNAL OF CANCER
(2017)
Article
Pharmacology & Pharmacy
Glyn B. Steventon, Samera Khan, Stephen C. Mitchell
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2018)
Article
Medicine, Research & Experimental
Glyn B. Steventon, Stephen C. Mitchell
MEDICAL HYPOTHESES
(2018)
Article
Pharmacology & Pharmacy
Glyn B. Steventon, Stephen C. Mitchell
Article
Biochemistry & Molecular Biology
Glyn B. Steventon, Stephen C. Mitchell, Santigo Angulo, Coral Barbas
Review
Biochemistry & Molecular Biology
Stephen C. Mitchell, Glyn B. Steventon
CURRENT DRUG METABOLISM
(2018)
Review
Pharmacology & Pharmacy
Steve C. Mitchell, Glyn B. Steventon
DRUG METABOLISM REVIEWS
(2012)
Article
Pharmacology & Pharmacy
B. Boonyapiwat, N. Sarisuta, Y. Ma, G. B. Steventon
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2011)
Editorial Material
Pharmacology & Pharmacy
Stephen Mitchell, Glyn Steventon, Rosemary Waring
Review
Pharmacology & Pharmacy
Glyn Steventon
Review
Pharmacology & Pharmacy
Stephen C. Mitchell, Glyn B. Steventon
Editorial Material
Pharmacology & Pharmacy
Stephen Mitchell, Glyn Steventon
Review
Pharmacology & Pharmacy
Glyn B. Steventon, Stephen C. Mitchell
Summary: S-Carboxymethyl-l-cysteine is a mucolytic agent used in the treatment of respiratory disorders, with multiple dose modeling indicating effective concentrations ranging from 1.30 to 8.40 μg/mL in the clinical setting. Pharmacodynamic studies reporting significant effects below approximately 10 μg/mL may occur in vivo, mainly through gene-related mechanisms. However, most events requiring levels much higher than achievable in clinical situations were only demonstrable in vitro.