Preclinical development of TLR ligands as drugs for the treatment of chronic viral infections

Intrinsic antiviral immunity

(2012) Nan Yan et al.   NATURE IMMUNOLOGY

Demonstration of safety and enhanced seroprotection against hepatitis B with investigational HBsAg-1018 ISS vaccine compared to a licensed hepatitis B vaccine

(2012) Benjamin P. Sablan et al.   VACCINE

Immunodeficiency lentiviral infections in natural and non-natural hosts

(2011) J. M. Brenchley et al.   BLOOD

Use of modelling and simulation techniques to support decision making on the progression of PF-04878691, a TLR7 agonist being developed for hepatitis C

(2011) Hannah M. Jones et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Hepatitis B surface antigen-1018 ISS adjuvant-containing vaccine: a review of HEPLISAV™ safety and efficacy

(2011) Curtis Cooper et al.   Expert Review of Vaccines

100 THERAPEUTIC EFFICACY OF THE TLR7 AGONIST GS-9620 FOR HBV CHRONIC INFECTION IN CHIMPANZEES

(2011) R.E. Lanford et al.   JOURNAL OF HEPATOLOGY

1114 ANTI-VIRAL EFFICACY AND INDUCTION OF AN ANTIBODY RESPONSE AGAINST SURFACE ANTIGEN WITH THE TLR7 AGONIST GS-9620 IN THE WOODCHUCK MODEL OF CHRONIC HBV INFECTION

(2011) S. Menne et al.   JOURNAL OF HEPATOLOGY

The Hepatitis B e antigen (HBeAg) targets and suppresses activation of the Toll-like receptor signaling pathway

(2011) Tali Lang et al.   JOURNAL OF HEPATOLOGY

TLR8 Activates HIV from Latently Infected Cells of Myeloid-Monocytic Origin Directly via the MAPK Pathway and from Latently Infected CD4 + T Cells Indirectly via TNF-α

(2011) Erika Schlaepfer et al.   JOURNAL OF IMMUNOLOGY

A genetically humanized mouse model for hepatitis C virus infection

(2011) Marcus Dorner et al.   NATURE

The utility of the new generation of humanized mice to study HIV-1 infection: transmission, prevention, pathogenesis, and treatment

(2011) Bradford K Berges et al.   Retrovirology

HIV reservoirs and latency models

(2011) Matthew J. Pace et al.   VIROLOGY

Gaining a foothold: how HIV avoids innate immune recognition

(2010) Nan Yan et al.   CURRENT OPINION IN IMMUNOLOGY

Using 3 TLR ligands as a combination adjuvant induces qualitative changes in T cell responses needed for antiviral protection in mice

(2010) Qing Zhu et al.   JOURNAL OF CLINICAL INVESTIGATION

Human liver chimeric mice provide a model for hepatitis B and C virus infection and treatment

(2010) Karl-Dimiter Bissig et al.   JOURNAL OF CLINICAL INVESTIGATION

Animal model for study of human hepatitis viruses

(2010) Kazuaki Chayama et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Hepatitis B virus polymerase inhibits RIG-I- and Toll-like receptor 3-mediated beta interferon induction in human hepatocytes through interference with interferon regulatory factor 3 activation and dampening of the interaction between TBK1/IKK  and DDX3

(2010) S. Yu et al.   JOURNAL OF GENERAL VIROLOGY

Polyinosinic-Polycytidylic Acid Treatment of Friend Retrovirus-Infected Mice Improves Functional Properties of Virus-Specific T Cells and Prevents Virus-Induced Disease

(2010) K. Gibbert et al.   JOURNAL OF IMMUNOLOGY

Inhibition of Hepatitis B Virus Replication by MyD88 Involves Accelerated Degradation of Pregenomic RNA and Nuclear Retention of Pre-S/S RNAs

(2010) J. Li et al.   JOURNAL OF VIROLOGY

The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1

(2010) Nan Yan et al.   NATURE IMMUNOLOGY

A Tonsillar PolyICLC/AT-2 SIV Therapeutic Vaccine Maintains Low Viremia Following Antiretroviral Therapy Cessation

(2010) Panagiotis Vagenas et al.   PLoS One

Hepatitis B virus core antigen determines viral persistence in a C57BL/6 mouse model

(2010) Y.-J. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Innate Antiviral Immune Responses to Hepatitis B Virus

(2010) Malika Ait-goughoulte et al.   Viruses-Basel

Primary cell models of HIV latency

(2010) Hung-Chih Yang   Current Opinion in HIV and AIDS

Hepatitis B Virus Polymerase Blocks Pattern Recognition Receptor Signaling via Interaction with DDX3: Implications for Immune Evasion

(2010) Haifeng Wang et al.   PLoS Pathogens

Toll-like receptor expression and responsiveness are increased in viraemic HIV-1 infection

(2009) Richard T Lester et al.   AIDS

Lipopolysaccharide-induced innate immune responses in primary hepatocytes downregulates woodchuck hepatitis virus replication via interferon-independent pathways

(2009) Xiaoyong Zhang et al.   CELLULAR MICROBIOLOGY

Enhanced Antibody Responses Elicited by a CpG Adjuvant Do Not Improve the Protective Effect of an Aldrithiol-2-Inactivated Simian Immunodeficiency Virus Therapeutic AIDS Vaccine

(2009) Y. Wang et al.   Clinical and Vaccine Immunology

Control of hepatitis B virus replication by innate response of HepaRG cells

(2009) Julie Lucifora et al.   HEPATOLOGY

Not interferon, but interleukin-6 controls early gene expression in hepatitis B virus infection

(2009) Marianna Hösel et al.   HEPATOLOGY

Impaired expression and function of toll-like receptor 7 in hepatitis C virus infection in human hepatoma cells

(2009) Serena Chang et al.   HEPATOLOGY

Toll-like receptor-induced innate immune responses in non-parenchymal liver cells are cell type-specific

(2009) Jun Wu et al.   IMMUNOLOGY

Toll-like receptor activated human and murine hepatic stellate cells are potent regulators of hepatitis C virus replication

(2009) Bo Wang et al.   JOURNAL OF HEPATOLOGY

Toll-Like Receptor 3 Mediates Establishment of an Antiviral State against Hepatitis C Virus in Hepatoma Cells

(2009) N. Wang et al.   JOURNAL OF VIROLOGY

Induction of a Striking Systemic Cytokine Cascade prior to Peak Viremia in Acute Human Immunodeficiency Virus Type 1 Infection, in Contrast to More Modest and Delayed Responses in Acute Hepatitis B and C Virus Infections

(2009) A. R. Stacey et al.   JOURNAL OF VIROLOGY

HCV Animal Models: A Journey of More than 30 Years

(2009) Philip Meuleman et al.   Viruses-Basel

The SET Complex Acts as a Barrier to Autointegration of HIV-1

(2009) Nan Yan et al.   PLoS Pathogens

Expression profiles and function of Toll-like receptors 2 and 4 in peripheral blood mononuclear cells of chronic hepatitis B patients

(2008) Zhiao Chen et al.   CLINICAL IMMUNOLOGY

Hepatitis B virus suppresses toll-like receptor-mediated innate immune responses in murine parenchymal and nonparenchymal liver cells

(2008) Jun Wu et al.   HEPATOLOGY

Toll-like receptor-stimulated non-parenchymal liver cells can regulate hepatitis C virus replication

(2008) Ruth Broering et al.   JOURNAL OF HEPATOLOGY

Characterization of the innate immune signalling pathways in hepatocyte cell lines

(2008) S. Preiss et al.   JOURNAL OF VIRAL HEPATITIS

Double-Stranded RNA Analog Poly(I:C) Inhibits Human Immunodeficiency Virus Amplification in Dendritic Cells via Type I Interferon-Mediated Activation of APOBEC3G

(2008) S. Trapp et al.   JOURNAL OF VIROLOGY

Activation of Pattern Recognition Receptor-Mediated Innate Immunity Inhibits the Replication of Hepatitis B Virus in Human Hepatocyte-Derived Cells

(2008) H. Guo et al.   JOURNAL OF VIROLOGY

Hepatitis B Virus Infection

(2008) Jules L. Dienstag   NEW ENGLAND JOURNAL OF MEDICINE

A Review of the Role of CpG Oligodeoxynucleotides as Toll-Like Receptor 9 Agonists in Prophylactic and Therapeutic Vaccine Development in Infectious Diseases

(2008) Kaveri Gupta et al.   Drugs in research & development