Overview of recent drug discovery approaches for new generation leukotriene A4 hydrolase inhibitors

A Novel Proteolytic Cascade Generates an Extracellular Matrix-Derived Chemoattractant in Chronic Neutrophilic Inflammation

(2014) A. Gaggar et al.   JOURNAL OF IMMUNOLOGY

Novel Anti-Inflammatory-Pro-Resolving Mediators and Their Receptors

(2012) Charles N. Serhan et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Molecular Dynamics Simulation Study and Hybrid Pharmacophore Model Development in Human LTA4H Inhibitor Design

(2012) Sundarapandian Thangapandian et al.   PLoS One

Effect of the leukotriene A4 hydrolase aminopeptidase augmentor 4-methoxydiphenylmethane in a pre-clinical model of pulmonary emphysema

(2011) Eliseu O. De Oliveira et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Lipoxygenase and Leukotriene Pathways: Biochemistry, Biology, and Roles in Disease

(2011) Jesper Z. Haeggström et al.   CHEMICAL REVIEWS

Pharmacophore-based virtual screening and Bayesian model for the identification of potential human leukotriene A4 hydrolase inhibitors

(2011) Sundarapandian Thangapandian et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Dual Target Inhibitors against Cyclooxygenases and Leukotriene A4Hydrolyase

(2011) Zheng Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

5-Lipoxygenase-Activating Protein (FLAP) Inhibitors. Part 4: Development of 3-[3-tert-Butylsulfanyl-1-[4-(6-ethoxypyridin-3-yl)benzyl]-5-(5-methylpyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethylpropionic Acid (AM803), a Potent, Oral, Once Daily FLAP Inhibitor

(2011) Nicholas S. Stock et al.   JOURNAL OF MEDICINAL CHEMISTRY

Leukotriene A4 hydrolase: an anti-inflammatory role for a proinflammatory enzyme

(2011) R. J. Snelgrove   THORAX

Novel Lipid Mediators and Resolution Mechanisms in Acute Inflammation

(2010) Charles N. Serhan   AMERICAN JOURNAL OF PATHOLOGY

Structures and mechanisms of enzymes in the leukotriene cascade

(2010) Agnes Rinaldo-Matthis et al.   BIOCHIMIE

Discovery of novel leukotriene A4 hydrolase inhibitors based on piperidine and piperazine scaffolds

(2010) Vincent Sandanayaka et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

5-Lipoxygenase-activating protein inhibitors. Part 3: 3-{3-tert-Butylsulfanyl-1-[4-(5-methoxy-pyrimidin-2-yl)-benzyl]-5-(5-methyl-pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM643)—A potent FLAP inhibitor suitable for topical administration

(2010) Nicholas Stock et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Leukotrienes and Atherosclerosis

(2010) Graziano Riccioni et al.   CURRENT DRUG TARGETS

Crystal structure of leukotriene A4hydrolase in complex with kelatorphan, implications for design of zinc metallopeptidase inhibitors

(2010) Fredrik Tholander et al.   FEBS LETTERS

Molecular Docking and Pharmacophore Filtering in the Discovery of Dual-Inhibitors for Human Leukotriene A4 Hydrolase and Leukotriene C4 Synthase

(2010) Sundarapandian Thangapandian et al.   Journal of Chemical Information and Modeling

A Critical Role for LTA4H in Limiting Chronic Pulmonary Neutrophilic Inflammation

(2010) R. J. Snelgrove et al.   SCIENCE

The Discovery of Setileuton, a Potent and Selective 5-Lipoxygenase Inhibitor

(2010) Yves Ducharme et al.   ACS Medicinal Chemistry Letters

Synthesis and structural assignment of two major metabolites of the LTA4H inhibitor DG-051

(2009) Livia A. Enache et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

5-Lipoxygenase-activating protein inhibitors. Part 2: 3-{5-((S)-1-Acetyl-2,3-dihydro-1H-indol-2-ylmethoxy)-3-tert-butylsulfanyl-1-[4-(5-methoxy-pyrimidin-2-yl)-benzyl]-1H-indol-2-yl}-2,2-dimethyl-propionic acid (AM679)—A potent FLAP inhibitor

(2009) Nicholas Stock et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

[6]-Gingerol Suppresses Colon Cancer Growth by Targeting Leukotriene A4 Hydrolase

(2009) Chul-Ho Jeong et al.   CANCER RESEARCH

The Presence of a Matrix-Derived Neutrophil Chemoattractant in Bronchiolitis Obliterans Syndrome after Lung Transplantation

(2009) M. T. Hardison et al.   JOURNAL OF IMMUNOLOGY

Discovery of Leukotriene A4 Hydrolase Inhibitors Using Metabolomics Biased Fragment Crystallography†

(2009) Douglas R. Davies et al.   JOURNAL OF MEDICINAL CHEMISTRY

5-Lipoxygenase-Activating Protein Inhibitors: Development of 3-[3-tert-Butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic Acid (AM103)

(2009) John H. Hutchinson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of 4-[(2S)-2-{[4-(4-Chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl]butanoic Acid (DG-051) as a Novel Leukotriene A4 Hydrolase Inhibitor of Leukotriene B4 Biosynthesis

(2009) Vincent Sandanayaka et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase

(2008) Thomas A. Kirkland et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Discovery of novel and potent aryl diamines as leukotriene A4 hydrolase inhibitors

(2008) Seock-Kyu Khim et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of N-alkyl glycine amides as potent inhibitors of leukotriene A4 hydrolase

(2008) Bin Ye et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and biological evaluation of N-mercaptoacylproline and N-mercaptoacylthiazolidine-4-carboxylic acid derivatives as leukotriene A4 hydrolase inhibitors

(2008) Hiroshi Enomoto et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Activation and inhibition of leukotriene A4 hydrolase aminopeptidase activity by diphenyl ether and derivatives

(2008) Xiaolu Jiang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and biological evaluation of N-mercaptoacylcysteine derivatives as leukotriene A4 hydrolase inhibitors

(2008) Hiroshi Enomoto et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structure-Based Dissection of the Active Site Chemistry of Leukotriene A4 Hydrolase: Implications for M1 Aminopeptidases and Inhibitor Design

(2008) Fredrik Tholander et al.   CHEMISTRY & BIOLOGY

Current status of leukotriene A4hydrolase inhibitors

(2008) Cheryl A Grice et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Discovery of Multitarget Inhibitors by Combining Molecular Docking with Common Pharmacophore Matching

(2008) Dengguo Wei et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of a Potent, Selective, and Orally Active Leukotriene A4Hydrolase Inhibitor with Anti-Inflammatory Activity

(2008) Cheryl A. Grice et al.   JOURNAL OF MEDICINAL CHEMISTRY

Potential Role of Leukotriene Modifiers in the Treatment of Chronic Obstructive Pulmonary Disease

(2008) Justin B Usery et al.   PHARMACOTHERAPY

The nuclear membrane organization of leukotriene synthesis

(2008) A. K. Mandal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA