Novel approaches to flavivirus drug discovery

Safety and Immunogenicity of a Tetravalent Live-Attenuated Dengue Vaccine in Flavivirus-Naive Infants

(2011) Veerachai Watanaveeradej et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Celgosivir treatment misfolds dengue virus NS1 protein, induces cellular pro-survival genes and protects against lethal challenge mouse model

(2011) Abhay P.S. Rathore et al.   ANTIVIRAL RESEARCH

RNA interference inhibits replication of tick-borne encephalitis virus in vitro

(2011) Katharina Achazi et al.   ANTIVIRAL RESEARCH

The membrane-active regions of the dengue virus proteins C and E

(2011) Henrique Nemésio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Self-Assembling Peptide Nanotubes with Antiviral Activity against Hepatitis C Virus

(2011) Ana Montero et al.   CHEMISTRY & BIOLOGY

Better late than never: antivirals for dengue

(2011) Stuart T. Perry et al.   Expert Review of Anti-Infective Therapy

Binding of Flavivirus Nonstructural Protein NS1 to C4b Binding Protein Modulates Complement Activation

(2011) P. Avirutnan et al.   JOURNAL OF IMMUNOLOGY

Design, Synthesis, and Biological Evaluation of Thiazoles Targeting Flavivirus Envelope Proteins

(2011) Abdelrahman S. Mayhoub et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Single Amino Acid in Nonstructural Protein NS4B Confers Virulence to Dengue Virus in AG129 Mice through Enhancement of Viral RNA Synthesis

(2011) D. Grant et al.   JOURNAL OF VIROLOGY

Inhibition of Dengue Virus by Targeting Viral NS4B Protein

(2011) X. Xie et al.   JOURNAL OF VIROLOGY

The F1 Motif of Dengue Virus Polymerase NS5 Is Involved in Promoter-Dependent RNA Synthesis

(2011) N. G. Iglesias et al.   JOURNAL OF VIROLOGY

Countering hepatitis B virus infection using RNAi: how far are we from the clinic?

(2011) Dejana Ivacik et al.   REVIEWS IN MEDICAL VIROLOGY

Characterization of the RepliVax platform for replication-defective flavivirus vaccines

(2011) Alexander A. Rumyantsev et al.   VACCINE

N-linked glycosylation of dengue virus NS1 protein modulates secretion, cell-surface expression, hexamer stability, and interactions with human complement

(2011) Pawit Somnuke et al.   VIROLOGY

Lycorine reduces mortality of human enterovirus 71-infected mice by inhibiting virus replication

(2011) Jiangning Liu et al.   Virology Journal

Flavivirus Cell Entry and Membrane Fusion

(2011) Jolanda Smit et al.   Viruses-Basel

Viral entry inhibitors block dengue antibody-dependent enhancement in vitro

(2010) Cindo O. Nicholson et al.   ANTIVIRAL RESEARCH

Antagonism of the complement component C4 by flavivirus nonstructural protein NS1

(2010) Panisadee Avirutnan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Peptide Inhibitors of Flavivirus Entry Derived from the E Protein Stem

(2010) A. G. Schmidt et al.   JOURNAL OF VIROLOGY

West Nile Virus Differentially Modulates the Unfolded Protein Response To Facilitate Replication and Immune Evasion

(2010) R. L. Ambrose et al.   JOURNAL OF VIROLOGY

Dengue virus nonstructural protein 3 redistributes fatty acid synthase to sites of viral replication and increases cellular fatty acid synthesis

(2010) N. S. Heaton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Viral determinants in the NS3 helicase and 2K peptide that promote West Nile virus resistance to antiviral action of 2′,5′-oligoadenylate synthetase 1b

(2010) Eva Mertens et al.   VIROLOGY

Structural Optimization and De Novo Design of Dengue Virus Entry Inhibitory Peptides

(2010) Joshua M. Costin et al.   PLoS Neglected Tropical Diseases

Peptide Inhibitors of Dengue-Virus Entry Target a Late-Stage Fusion Intermediate

(2010) Aaron G. Schmidt et al.   PLoS Pathogens

Identification of Inhibitors of Yellow Fever Virus Replication Using a Replicon-Based High-Throughput Assay

(2009) C. G. Patkar et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A Small-Molecule Dengue Virus Entry Inhibitor

(2009) Q.-Y. Wang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In silico screening of small molecule libraries using the dengue virus envelope E protein has identified compounds with antiviral activity against multiple flaviviruses

(2009) Thorsten Kampmann et al.   ANTIVIRAL RESEARCH

A small molecule fusion inhibitor of dengue virus

(2009) Mee Kian Poh et al.   ANTIVIRAL RESEARCH

In vitro assembly of nucleocapsid-like particles from purified recombinant capsid protein of dengue-2 virus

(2009) Carlos López et al.   ARCHIVES OF VIROLOGY

Identification of novel target sites and an inhibitor of the dengue virus E protein

(2009) Ragothaman Yennamalli et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

The flavivirus NS5 protein is a true RNA guanylyltransferase that catalyzes a two-step reaction to form the RNA cap structure

(2009) M. Issur et al.   RNA

RNA interference inhibits yellow fever virus replication in vitro and in vivo

(2009) Carolina C. Pacca et al.   VIRUS GENES

Antiviral Compounds Discovered by Virtual Screening of Small−Molecule Libraries against Dengue Virus E Protein

(2008) Zhigang Zhou et al.   ACS Chemical Biology

Closing the door on flaviviruses: Entry as a target for antiviral drug design

(2008) Rushika Perera et al.   ANTIVIRAL RESEARCH

Flavivirus methyltransferase: A novel antiviral target

(2008) Hongping Dong et al.   ANTIVIRAL RESEARCH

Design, Synthesis, and Biological Evaluation of Antiviral Agents Targeting Flavivirus Envelope Proteins

(2008) Ze Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Modification of intracellular membrane structures for virus replication

(2008) Sven Miller et al.   NATURE REVIEWS MICROBIOLOGY

The Flavivirus Precursor Membrane-Envelope Protein Complex: Structure and Maturation

(2008) L. Li et al.   SCIENCE

Structure of the Immature Dengue Virus at Low pH Primes Proteolytic Maturation

(2008) I-M. Yu et al.   SCIENCE

A single-amino acid substitution in West Nile virus 2K peptide between NS4A and NS4B confers resistance to lycorine, a flavivirus inhibitor

(2008) Gang Zou et al.   VIROLOGY

Inhibition of West Nile virus replication in cells stably transfected with vector-based shRNA expression system

(2008) S.P. Ong et al.   VIRUS RESEARCH