Therapeutics for filovirus infection: traditional approaches and progress towardsin silicodrug design

Advanced morpholino oligomers: A novel approach to antiviral therapy

(2012) Travis K. Warren et al.   ANTIVIRAL RESEARCH

Imatinib and Beyond – Targeting Activated Tyrosine Kinases in Myeloproliferative Disorders

(2012) Andreas Hochhaus et al.   ONKOLOGIE

Structural dissection of Ebola virus and its assembly determinants using cryo-electron tomography

(2012) T. A. M. Bharat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Productive Replication of Ebola Virus Is Regulated by the c-Abl1 Tyrosine Kinase

(2012) M. Garcia et al.   Science Translational Medicine

The Ebola Virus Interferon Antagonist VP24 Directly Binds STAT1 and Has a Novel, Pyramidal Fold

(2012) Adrianna P. P. Zhang et al.   PLoS Pathogens

Humanized mice as a preclinical tool for infectious disease and biomedical research

(2011) Leonard D. Shultz et al.   Annals of the New York Academy of Sciences

Identification of an antioxidant small-molecule with broad-spectrum antiviral activity

(2011) Rekha G. Panchal et al.   ANTIVIRAL RESEARCH

Inhibition of Lassa virus and Ebola virus infection in host cells treated with the kinase inhibitors genistein and tyrphostin

(2011) Andrey A. Kolokoltsov et al.   ARCHIVES OF VIROLOGY

Ebola and Marburg haemorrhagic fever viruses: major scientific advances, but a relatively minor public health threat for Africa

(2011) E.M. Leroy et al.   CLINICAL MICROBIOLOGY AND INFECTION

Proteins that bind and move lipids: MsbA and NPC1

(2011) Gavin King et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Nonhuman primates as models for the discovery and development of ebolavirus therapeutics

(2011) Amy C Shurtleff et al.   Expert Opinion on Drug Discovery

Filovirus Infection of STAT-1 Knockout Mice

(2011) JoLynne Raymond et al.   JOURNAL OF INFECTIOUS DISEASES

Basic Clinical and Laboratory Features of Filoviral Hemorrhagic Fever

(2011) Mark G. Kortepeter et al.   JOURNAL OF INFECTIOUS DISEASES

Characterization of Filovirus Protein–Protein Interactions in Mammalian Cells Using Bimolecular Complementation

(2011) Yuliang Liu et al.   JOURNAL OF INFECTIOUS DISEASES

Advances in Virus-Like Particle Vaccines for Filoviruses

(2011) Kelly L. Warfield et al.   JOURNAL OF INFECTIOUS DISEASES

Pathogenesis of Marburg Hemorrhagic Fever in Cynomolgus Macaques

(2011) Lisa E. Hensley et al.   JOURNAL OF INFECTIOUS DISEASES

Discovery, Synthesis, and Biological Evaluation of a Novel Group of Selective Inhibitors of Filoviral Entry

(2011) Maria V. Yermolina et al.   JOURNAL OF MEDICINAL CHEMISTRY

A New Ebola Virus Nonstructural Glycoprotein Expressed through RNA Editing

(2011) M. Mehedi et al.   JOURNAL OF VIROLOGY

Identification of a Small-Molecule Entry Inhibitor for Filoviruses

(2011) A. Basu et al.   JOURNAL OF VIROLOGY

Strategies on the Development of Small Molecule Anticancer Drugs for Targeted Therapy

(2011) Y.-H. Lu et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Small molecule inhibitors reveal Niemann–Pick C1 is essential for Ebola virus infection

(2011) Marceline Côté et al.   NATURE

Ebola virus entry requires the cholesterol transporter Niemann–Pick C1

(2011) Jan E. Carette et al.   NATURE

A small nonhuman primate model for filovirus-induced disease

(2011) Ricardo Carrion et al.   VIROLOGY

EbolavirusVP35 is a multifunctional virulence factor

(2011) Daisy W. Leung et al.   Virulence

Cryo-Electron Tomography of Marburg Virus Particles and Their Morphogenesis within Infected Cells

(2011) Tanmay A. M. Bharat et al.   PLOS BIOLOGY

Antiviral Activity of a Small-Molecule Inhibitor of Filovirus Infection

(2010) T. K. Warren et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Spiroimidazolidinone NPC1L1 inhibitors. Part 2: Structure–activity studies and in vivo efficacy

(2010) Kobporn L. Howell et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Tsg101 Is Recruited by a Late Domain of the Nucleocapsid Protein To Support Budding of Marburg Virus-Like Particles

(2010) O. Dolnik et al.   JOURNAL OF VIROLOGY

Postexposure protection of non-human primates against a lethal Ebola virus challenge with RNA interference: a proof-of-concept study

(2010) Thomas W Geisbert et al.   LANCET

Identification of Essential Filovirion-associated Host Factors by Serial Proteomic Analysis and RNAi Screen

(2010) Kevin B. Spurgers et al.   MOLECULAR & CELLULAR PROTEOMICS

Advanced antisense therapies for postexposure protection against lethal filovirus infections

(2010) Travis K Warren et al.   NATURE MEDICINE

Aerosol Exposure to the Angola Strain of Marburg Virus Causes Lethal Viral Hemorrhagic Fever in Cynomolgus Macaques

(2010) D. A. Alves et al.   VETERINARY PATHOLOGY

Establishing Efficacy of Human Products Using Animals

(2010) P. J. Snoy   VETERINARY PATHOLOGY

Marburg Virus Evades Interferon Responses by a Mechanism Distinct from Ebola Virus

(2010) Charalampos Valmas et al.   PLoS Pathogens

Techniques and tactics used in determining the structure of the trimericebolavirusglycoprotein

(2009) Jeffrey E. Lee et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Expression, purification, crystallization and preliminary X-ray studies of the Ebola VP35 interferon inhibitory domain

(2009) Daisy W. Leung et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Development of a broad-spectrum antiviral with activity against Ebola virus

(2009) M. Javad Aman et al.   ANTIVIRAL RESEARCH

Spiroimidazolidinone NPC1L1 inhibitors. 1: Discovery by 3D-similarity-based virtual screening

(2009) Daniel R. McMasters et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structure of N-Terminal Domain of NPC1 Reveals Distinct Subdomains for Binding and Transfer of Cholesterol

(2009) Hyock Joo Kwon et al.   CELL

Neutralizing ebolavirus: structural insights into the envelope glycoprotein and antibodies targeted against it

(2009) Jeffrey E Lee et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Disease modeling for Ebola and Marburg viruses

(2009) D. Bente et al.   Disease Models & Mechanisms

Identification of novel cellular targets for therapeutic intervention against Ebola virus infection by siRNA screening

(2009) Andrey A. Kolokoltsov et al.   DRUG DEVELOPMENT RESEARCH

Update on patented cholesterol absorption inhibitors

(2009) M T Chhabria et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Ebolavirusglycoprotein structure and mechanism of entry

(2009) Jeffrey E Lee et al.   Future Virology

Development and Characterization of a Mouse Model for Marburg Hemorrhagic Fever

(2009) K. L. Warfield et al.   JOURNAL OF VIROLOGY

Ebolavirus VP24 Binding to Karyopherins Is Required for Inhibition of Interferon Signaling

(2009) M. Mateo et al.   JOURNAL OF VIROLOGY

Cholesterol Synthesis Inhibitor U18666A and the Role of Sterol Metabolism and Trafficking in Numerous Pathophysiological Processes

(2009) Richard J. Cenedella   LIPIDS

Structure of the Ebola VP35 interferon inhibitory domain

(2009) D. W. Leung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tetherin-mediated restriction of filovirus budding is antagonized by the Ebola glycoprotein

(2009) Rachel L. Kaletsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

No exit: Targeting the budding process to inhibit filovirus replication

(2008) Ronald N. Harty   ANTIVIRAL RESEARCH

Imatinib and Its Successors – How Modern Chemistry has Changed Drug Development

(2008) Bernhard Muller   CURRENT PHARMACEUTICAL DESIGN

Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor

(2008) Jeffrey E. Lee et al.   NATURE

Extracellular loop C of NPC1L1 is important for binding to ezetimibe

(2008) A. B. Weinglass et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery and development of antiviral drugs for biodefense: Experience of a small biotechnology company

(2007) Tove C. Bolken et al.   ANTIVIRAL RESEARCH

NIAID resources for developing new therapies for severe viral infections

(2007) Heather Greenstone et al.   ANTIVIRAL RESEARCH