Discovery of novel antibacterials

Discovery of Antibacterial Biotin Carboxylase Inhibitors by Virtual Screening and Fragment-Based Approaches

(2009) Igor Mochalkin et al.   ACS Chemical Biology

High-Throughput Screen for Novel Antimicrobials using a Whole Animal Infection Model

(2009) Terence I. Moy et al.   ACS Chemical Biology

Microbial Iron Acquisition: Marine and Terrestrial Siderophores

(2009) Moriah Sandy et al.   CHEMICAL REVIEWS

Exploring the Positional Attachment of Glycopeptide/β-lactam Heterodimers

(2009) Daniel D Long et al.   JOURNAL OF ANTIBIOTICS

Has the era of untreatable infections arrived?

(2009) D. M. Livermore   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Type II fatty acid synthesis is not a suitable antibiotic target for Gram-positive pathogens

(2009) Sophie Brinster et al.   NATURE

Chemical genomics in Escherichia coli identifies an inhibitor of bacterial lipoprotein targeting

(2009) Ranjana Pathania et al.   Nature Chemical Biology

Structural insight into the quinolone–DNA cleavage complex of type IIA topoisomerases

(2009) Ivan Laponogov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A class of selective antibacterials derived from a protein kinase inhibitor pharmacophore

(2009) J. Richard Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of a liquid chromatography/mass spectrometry-based drug accumulation assay in Pseudomonas aeruginosa

(2008) Hongliang Cai et al.   ANALYTICAL BIOCHEMISTRY

Discovery and Characterization of QPT-1, the Progenitor of a New Class of Bacterial Topoisomerase Inhibitors

(2008) A. A. Miller et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Ligand-Based Approaches in Virtual Screening

(2008) Dominique Douguet   Current Computer-Aided Drug Design

Has nature already identified all useful antibacterial targets?

(2008) Dirk Bumann   CURRENT OPINION IN MICROBIOLOGY

Recent advances in bacterial topoisomerase inhibitors

(2008) B BRADBURY et al.   CURRENT OPINION IN PHARMACOLOGY

How many modes of action should an antibiotic have?

(2008) H BROTZOESTERHELT et al.   CURRENT OPINION IN PHARMACOLOGY

Predicting Antimicrobial Drugs and Targets with the MARCH-INSIDE Approach

(2008) Humberto Gonzalez-Diaz et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Recent Developments in Fragment-Based Drug Discovery

(2008) Miles Congreve et al.   JOURNAL OF MEDICINAL CHEMISTRY

Physicochemical Properties of Antibacterial Compounds: Implications for Drug Discovery

(2008) Rosemarie O’Shea et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fragment approaches in structure-based drug discovery

(2008) Roderick E. Hubbard   JOURNAL OF SYNCHROTRON RADIATION

Trench Warfare in a Battle With TB

(2008) E. Marshall   SCIENCE

An Inhibitor of FtsZ with Potent and Selective Anti-Staphylococcal Activity

(2008) D. J. Haydon et al.   SCIENCE