Exemplification of the challenges associated with utilising fluorescence intensity based assays in discovery

Peptide processing and biology in human disease

(2011) Suzana Kovac et al.   Current Opinion in Endocrinology Diabetes and Obesity

Mammalian Sirtuins: Biological Insights and Disease Relevance

(2010) Marcia C. Haigis et al.   Annual Review of Pathology-Mechanisms of Disease

SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1

(2010) Michelle Pacholec et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multiple sclerosis: Closing in on an oral treatment

(2010) Roland Martin   NATURE

Targeting Bcr–Abl by combining allosteric with ATP-binding-site inhibitors

(2010) Jianming Zhang et al.   NATURE

Development of inductively coupled plasma–mass spectrometry-based protease assays

(2009) Urja S. Lathia et al.   ANALYTICAL BIOCHEMISTRY

Antibody-mediated disruption of the interaction between PCSK9 and the low-density lipoprotein receptor

(2009) Christopher J. Duff et al.   BIOCHEMICAL JOURNAL

The biochemical pharmacology of renin inhibitors: Implications for translational medicine in hypertension, diabetic nephropathy and heart failure: Expectations and reality

(2009) Zaid Abassi et al.   BIOCHEMICAL PHARMACOLOGY

Binding to the Low-Density Lipoprotein Receptor Accelerates Futile Catalytic Cycling in PCSK9 and Raises the Equilibrium Level of Intramolecular Acylenzyme

(2009) Kieran F. Geoghegan et al.   BIOCHEMISTRY

Processing of peptide and hormone precursors at the dibasic cleavage sites

(2009) Mohamed Rholam et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Resveratrol is Not a Direct Activator of SIRT1 Enzyme Activity

(2009) Dirk Beher et al.   Chemical Biology & Drug Design

Saquinavir, the pioneer antiretroviral protease inhibitor

(2009) Charles JL la Porte   Expert Opinion on Drug Metabolism & Toxicology

Quantitative Analyses of Aggregation, Autofluorescence, and Reactivity Artifacts in a Screen for Inhibitors of a Thiol Protease

(2009) Ajit Jadhav et al.   JOURNAL OF MEDICINAL CHEMISTRY

A 100K well screen for a muscarinic receptor using the Epic®label-free system – a reflection on the benefits of the label-free approach to screening seven-transmembrane receptors

(2009) K. Dodgson et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Fas-Mediated Apoptosis Is Regulated by the Extracellular Matrix Protein CCN1 (CYR61) In Vitro and In Vivo

(2009) V. Juric et al.   MOLECULAR AND CELLULAR BIOLOGY

Pharmaceutical R&D: the road to positive returns

(2009) Eric David et al.   NATURE REVIEWS DRUG DISCOVERY

Lessons from 60 years of pharmaceutical innovation

(2009) Bernard Munos   NATURE REVIEWS DRUG DISCOVERY

A Specific Mechanism for Nonspecific Activation in Reporter-Gene Assays

(2008) Douglas S. Auld et al.   ACS Chemical Biology

Bright Ideas for Chemical Biology

(2008) Luke D. Lavis et al.   ACS Chemical Biology

Fluorescence polarization immunoassays and related methods for simple, high-throughput screening of small molecules

(2008) David S. Smith et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Mechanisms and Molecular Probes of Sirtuins

(2008) Brian C. Smith et al.   CHEMISTRY & BIOLOGY

The activation and physiological functions of the proprotein convertases

(2008) N SEIDAH et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Structural and Biochemical Characterization of the Wild Type PCSK9-EGF(AB) Complex and Natural Familial Hypercholesterolemia Mutants

(2008) Matthew J. Bottomley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY