Rebinding: or why drugs may act longerin vivothan expected from theirin vitrotarget residence time

The dynamics of drug-target interactions: drug-target residence time and its impact on efficacy and safety

(2010) Robert A Copeland   Expert Opinion on Drug Discovery

Detection of angiotensin II type 1 receptor ligands by a cell-based assay

(2009) Matthias Grießner et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

On the mechanism of the persistent action of salmeterol: what is the current position?

(2009) RA Coleman   BRITISH JOURNAL OF PHARMACOLOGY

Molecular mechanisms for the persistent bronchodilatory effect of the β2-adrenoceptor agonist salmeterol

(2009) A Szczuka et al.   BRITISH JOURNAL OF PHARMACOLOGY

Evaluation of a 1,4,7,10-Tetraazacyclododecane-1,4,7,10-Tetraacetic Acid-Conjugated Bombesin-Based Radioantagonist for the Labeling with Single-Photon Emission Computed Tomography, Positron Emission Tomography, and Therapeutic Radionuclides

(2009) R. Mansi et al.   CLINICAL CANCER RESEARCH

Incorporating Receptor Theory in Mechanism-Based Pharmacokinetic-Pharmacodynamic (PK-PD) Modeling

(2009) Bart A. Ploeger et al.   Drug Metabolism and Pharmacokinetics

Analytical method for simultaneously measuring ex vivo drug receptor occupancy and dissociation rate: Application to (R)-dimethindene occupancy of central histamine H1receptors

(2009) Siobhan Malany et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Molecular imaging targeting peptide receptors

(2009) Margret Schottelius et al.   METHODS

Ligands, their receptors and … plasma membranes

(2009) G. Vauquelin et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Quantitation of cannabinoid CB1 receptors in healthy human brain using positron emission tomography and an inverse agonist radioligand

(2009) Garth E. Terry et al.   NEUROIMAGE

Antagonist-radioligand binding to D2L-receptors in intact cells

(2008) Ann Packeu et al.   BIOCHEMICAL PHARMACOLOGY

Residence Time of Receptor−Ligand Complexes and Its Effect on Biological Function

(2008) Peter J. Tummino et al.   BIOCHEMISTRY

Imaging of Urokinase-Type Plasminogen Activator Receptor Expression Using a 64Cu-Labeled Linear Peptide Antagonist by microPET

(2008) Z.-B. Li et al.   CLINICAL CANCER RESEARCH

Synthesis and evaluation of xanomeline analogs—Probing the wash-resistant phenomenon at the M1 muscarinic acetylcholine receptor

(2007) Brian E. Kane et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Molecular characterisation of the interactions between olmesartan and telmisartan and the human angiotensin II AT1 receptor

(2007) M T Le et al.   BRITISH JOURNAL OF PHARMACOLOGY

Kinetic analysis in healthy humans of a novel positron emission tomography radioligand to image the peripheral benzodiazepine receptor, a potential biomarker for inflammation

(2007) Masahiro Fujita et al.   NEUROIMAGE

Quantifying the association and dissociation rates of unlabelled antagonists at the muscarinic M3 receptor

(2006) Mark R Dowling et al.   BRITISH JOURNAL OF PHARMACOLOGY