Article
Chemistry, Medicinal
Chunmei Lu, Xiuting Wang, Qiqi Wang, Lixia Zhang, Jianguo Lin, Ling Qiu
Summary: Legumain is overexpressed in several cancers and serves as an important biomarker for cancer diagnosis. In this study, a novel radioactive tracer [F-18]SF-AAN was designed and synthesized for positron emission tomography (PET) imaging, targeting legumain. The tracer showed specificity in detecting legumain activity in vitro and in vivo, making it a promising tool for the diagnosis of legumain-related diseases.
Review
Biochemistry & Molecular Biology
Sarah K. Royse, Brian J. Lopresti, Chester A. Mathis, Savannah Tollefson, Rajesh Narendran
Summary: Early PET applications in psychiatry aimed to identify cerebral blood flow and metabolism abnormalities, but the need for more specific neurochemical imaging probes became evident. The development of monoaminergic PET radiopharmaceuticals was driven by the belief in the centrality of monoamine dysfunction in psychiatric disorders. However, as drug development shifted away from monoamines, new PET imaging agents for non-monoamine targets were developed. Part two of the review focuses on clinical research studies using these novel targets and radiotracers across different psychiatric disorders.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Yong Huang, Yajing Liu, Chengze Li, Zhongjing Li, Hualong Chen, Lu Zhang, Ying Liang, Zehui Wu
Summary: Glutamine metabolism-related tracer (2S,4S)-4-[F-18]FEBGln has the potential to visualize various tumors through PET imaging, with good tumor retention and contrast. It shows different retention capabilities in different tumor models. The tracer has potential in accurately diagnosing lung cancer and glioma, but cannot accurately determine prostate cancer.
MOLECULAR PHARMACEUTICS
(2023)
Article
Cardiac & Cardiovascular Systems
Evangelos Tzolos, Rong Bing, Jack Andrews, Mark G. MacAskill, Adriana A. S. Tavares, Gillian Macnaught, Tim Clark, Nicholas L. Mills, Takeshi Fujisawa, Jennifer Nash, Damini Dey, Piotr J. Slomka, Norman Koglin, Andrew W. Stephens, Marcus-Andre Deutsch, Edwin J. R. van Beek, Michelle C. Williams, Sven Hermann, Verena Hugenberg, Marc R. Dweck, David E. Newby
Summary: This study aimed to noninvasively detect in vivo thrombus formation in human coronary arteries using 18F-GP1 radiotracer through positron emission tomographic (PET) and computed tomographic (CT) imaging. The study found that coronary 18F-GP1 uptake was apparent in patients with acute myocardial infarction, which has the potential to inform the diagnosis, management, and treatment of these patients.
JACC-CARDIOVASCULAR IMAGING
(2023)
Article
Geriatrics & Gerontology
Liping Fu, Jinming Zhang, Kaixiang Zhou, Xiaojun Zhang, Hengge Xie, Mingwei Zhu, Mengchao Cui, Ruimin Wang
Summary: This study evaluates the effectiveness of a new tracer, [F-18]-S16, in distinguishing patients with AD from HCs. The results show that [F-18]-S16 exhibits increased cortical uptake in AD patients, suggesting its potential for in vivo detection of tau protein.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Brian J. Lopresti, Sarah K. Royse, Chester A. Mathis, Savannah A. Tollefson, Rajesh Narendran
Summary: With the emergence of PET, psychiatry gained access to a non-invasive tool for assessing human brain function. Early applications focused on measuring blood flow and metabolism, but specific probes for dopamine and serotonin receptors were later developed. However, the development of monoamine-enhancing drugs was not very successful, leading to a shift in drug development towards other targets. In recent years, PET imaging techniques have also been developed for studying non-monoamine targets.
JOURNAL OF NEUROCHEMISTRY
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Amanda Nguyen, Felipe Martinez, Ba D. Nguyen
Summary: This case report presents chest wall keloids detected on F-18-piflufolastat PET/CT during the evaluation of prostate cancer recurrence.
CLINICAL NUCLEAR MEDICINE
(2023)
Review
Oncology
Cristina Barca, Claudia Foray, Bastian Zinnhardt, Alexandra Winkeler, Ulrich Herrlinger, Oliver M. Grauer, Andreas H. Jacobs
Summary: This review provides a comprehensive overview of the experimental and clinical data on studying tumor heterogeneity in the tumor microenvironment using PET imaging, with a focus on the combination of amino acid and TSPO PET imaging.
Review
Biochemistry & Molecular Biology
Michael R. Kilbourn
Summary: The application of positron emission tomography (PET) imaging to study brain biochemistry, especially dopamine neurotransmission, has significantly grown over the past 40 years. PET imaging of dopaminergic functions in the central nervous system is routinely used for research in neurology, psychiatry, drug abuse and addiction, as well as drug development. The key advancement in PET imaging is the development of unique radiotracers labeled with positron-emitting radionuclides like carbon-11 and fluorine-18, which have greatly contributed to the progress in this field.
Article
Chemistry, Multidisciplinary
Dingyao Gao, Yinxing Miao, Siqin Ye, Chunmei Lu, Gaochao Lv, Ke Li, Chunjing Yu, Jianguo Lin, Ling Qiu
Summary: GGT is a key biomarker for cancer diagnosis due to its high expression in malignant tumors. A novel PET imaging probe, [F-18]GCPA(2), has been designed for targeted monitoring of GGT expression in living subjects, showing potential for clinical applications.
Review
Biochemical Research Methods
Xieyi Zhang, Takahito Nakajima, Kenta Mizoi, Yoshito Tsushima, Takuo Ogihara
Summary: NIR-PIT induces immediate cell death with NIR light, and the acute therapeutic effects should be monitored using imaging modalities. Different imaging modalities have their own advantages and disadvantages, and the suitable modality should be chosen based on specific purpose and conditions.
JOURNAL OF BIOPHOTONICS
(2022)
Article
Environmental Sciences
Samantha Delaney, Cindy Rodriguez, Samantha M. Sarrett, Eric J. Dayts, Brian M. Zeglis, Outi Keinanen
Summary: Microplastics and nanoplastics, ubiquitous environmental pollutants, pose a threat to human health. PET imaging was used to track the fate of these plastics when administered to mice via different routes. The study found that the distribution of plastic particles in the body differed depending on the administration route, and particle size significantly influenced their retention in the lungs.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Engineering, Biomedical
Abhijit J. Chaudhari, Ramsey D. Badawi
Summary: Nuclear medical imaging devices are typically optimized for whole-body imaging, but application-specific devices with superior technical characteristics have shown promise for organ imaging in niche applications. Efforts are needed to overcome design limitations and gather data to define the clinical value of these devices.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Review
Polymer Science
Leon Riehakainen, Chiara Cavallini, Paolo Armanetti, Daniele Panetta, Davide Caramella, Luca Menichetti
Summary: Non-invasive longitudinal imaging of biodegradable implant materials is essential for evaluating osseointegration of implants. Various imaging techniques can assess initial stability, bone quality and quantity, and tissue remodeling, providing valuable insights for biodegradable implant research.
Article
Hematology
Beth Whittington, Evangelos Tzolos, Rong Bing, Jack Andrews, Christophe Lucatelli, Mark G. Macaskill, Adriana A. S. Tavares, Tim Clark, Nicholas L. Mills, Jennifer Nash, Damini Dey, Piotr J. Slomka, Norman Koglin, Andrew W. Stephens, Edwin J. R. van Beek, Colin Smith, Marc R. Dweck, Michelle C. Williams, William Whiteley, Joanna M. Wardlaw, David E. Newby
Summary: Using F-18-GP1 positron emission tomography and computed tomography angiography, it is possible to identify activated platelets and thrombus noninvasively, which has potential clinical application in establishing the role and origin of thrombus in ischemic stroke.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Editorial Material
Chemistry, Medicinal
Edward James, Thomas L. Robertshaw, Andrew D. Westwell
FUTURE MEDICINAL CHEMISTRY
(2019)
Correction
Nanoscience & Nanotechnology
Brittany Haynes, Yanhua Zhang, Fangchao Liu, Jing Li, Sarah Petit, Hend Kothayer, Xun Bao, Andrew D. Westwell, Guangzhao Mao, Malathy P. V. Shekhar
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2019)
Article
Microbiology
Alessandra Crusco, Rafael Baptista, Sumana Bhowmick, Manfred Beckmann, Luis A. J. Mur, Andrew D. Westwell, Karl F. Hoffmann
FRONTIERS IN MICROBIOLOGY
(2019)
Article
Chemistry, Medicinal
Malamati Kourti, Jun Cai, Wen Jiang, Andrew D. Westwell
Summary: This study aimed at testing novel CORM molecules against angiogenesis in TNBC and found that a new CORM, complex 4, showed promising anti-angiogenic properties, making it a potential drug candidate for new therapies against this subtype of breast cancer.
MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Alessandra Cavaliere, Katrin C. Probst, Stephen J. Paisey, Christopher Marshall, Abdul K. H. Dheere, Franklin Aigbirhio, Christopher McGuigan, Andrew D. Westwell
Article
Integrative & Complementary Medicine
Zarith Nameyrra Md Nesran, Nurul Husna Shafie, Siti Farah Md Tohid, Mohd Esa Norhaizan, Amin Ismail
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Sahar B. Kandil, Samuel R. Jones, Sonia Smith, Stephen E. Hiscox, Andrew D. Westwell
Article
Chemistry, Medicinal
Sahar B. Kandil, Benson M. Kariuki, Christopher McGuigan, Andrew D. Westwell
Summary: A sulfoxide derivative exhibited significant anticancer activity in four different human prostate cancer cell lines, showing better inhibition compared to standard drugs. The efficient preparation method and potential clinical applications make it a promising candidate for further research and development.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Rania Hamdy, Samia A. Elseginy, Noha I. Ziedan, Mohamed El-Sadek, Elsaid Lashin, Arwyn T. Jones, Andrew D. Westwell
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Sahar B. Kandil, Christopher McGuigan, Andrew D. Westwell
Summary: A series of 15 bicalutamide analogues were synthesized and seven of them showed remarkable enhancement in anticancer activity across four prostate cancer cell lines. The deshydroxy analogue was the most active compound with a IC50 range of 6.59-10.86 µM. Molecular modeling explained the higher activity of the sulfide analogues compared to their sulfone counterparts.
Article
Oncology
Jitka Soukupova, Cinzia Bordoni, Daniel J. Turnham, William W. Yang, Gillian Seaton, Aleksandra Gruca, Rhiannon French, Kok Yung Lee, Athina Varnava, Luke Piggott, Richard W. E. Clarkson, Andrew D. Westwell, Andrea Brancale
Summary: The development of virtual screening methods for identifying Bcl3 inhibitors provides a new approach for effective antimetastatic therapy. JS6, as a potential therapeutic agent, shows activity in inhibiting Bcl3-NF-kB1 binding, tumor colony formation, and cancer cell migration.
MOLECULAR CANCER THERAPEUTICS
(2021)
Article
Immunology
Martin J. Scurr, Wioleta M. Zelek, George Lippiatt, Michelle Somerville, Stephanie E. A. Burnell, Lorenzo Capitani, Kate Davies, Helen Lawton, Thomas Tozer, Tara Rees, Kerry Roberts, Mererid Evans, Amanda Jackson, Charlotte Young, Lucy Fairclough, Paddy Tighe, Mark Wills, Andrew D. Westwell, B. Paul Morgan, Awen Gallimore, Andrew Godkin
Summary: Accurate assessment of SARS-CoV-2 immunity is crucial, with T-cell responses being a key feature for protection. A high-throughput assay was developed to determine T-cell responses, showing significant differences in previously infected individuals and vaccination recipients. IFN-gamma was more effective in identifying asymptomatic donors, but IL-2 had higher specificity in healthy donors.
Article
Biochemistry & Molecular Biology
Rania Hamdy, Arwyn T. Jones, Mohamed El-Sadek, Alshaimaa M. Hamoda, Sarra B. Shakartalla, Zainab M. Al Shareef, Sameh S. M. Soliman, Andrew D. Westwell
Summary: A series of novel compounds were synthesized and evaluated for their anti-apoptotic Bcl-2 inhibitory activity, showing selective growth-inhibitory activity against Bcl-2-expressing human cancer cell lines. The most potent compound demonstrated promising drug likeness criteria and high binding affinity for interrupting the Bcl-2-Bim interaction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Integrative & Complementary Medicine
Aifaa Akmal Baharuddin, Rushduddin Al Jufri Roosli, Zainul Amiruddin Zakaria, Siti Farah Md Tohid
Summary: Dicranopteris linearis plant extracts have been shown to possess numerous health-promoting properties, with potential to be developed into potent anticancer agents due to their antinociceptive, anti-inflammatory, antipyretic, chemopreventive, and antioxidant properties. These properties suggest a potential for treating inflammatory-related diseases and cancer.
BOLETIN LATINOAMERICANO Y DEL CARIBE DE PLANTAS MEDICINALES Y AROMATICAS
(2021)
Meeting Abstract
Oncology
Saswati Bhattacharya, Pam Westmark, Noah Siegel, Yuanqi Cai, Sahar Kandil, Andrew D. Westwell, Christopher McGuigan, Ruth O'Regan