Implications of endoplasmic reticulum stress, the unfolded protein response and apoptosis for molecular cancer therapy. Part I: targeting p53, Mdm2, GADD153/CHOP, GRP78/BiP and heat shock proteins

Nelfinavir induces the unfolded protein response in ovarian cancer cells, resulting in ER vacuolization, cell cycle retardation and apoptosis

(2010) Ansgar Brüning et al.   CANCER BIOLOGY & THERAPY

Chemotherapeutic sensitization by endoplasmic reticulum stress: Increasing the efficacy of taxane against prostate cancer

(2010) Yue Wu et al.   CANCER BIOLOGY & THERAPY

E2F1 and E2F3 activate ATM through distinct mechanisms to promote E1A-induced apoptosis

(2010) Sungki Hong et al.   CELL CYCLE

Untangling the unfolded protein response

(2010) Emma L. Davenport et al.   CELL CYCLE

Endoplasmic reticulum stress is involved in hydrogen peroxide induced apoptosis in immortalized and malignant human oral keratinocytes

(2010) Seung-Ki Min et al.   JOURNAL OF ORAL PATHOLOGY & MEDICINE

The unfolded protein response during prostate cancer development

(2009) Alex Yick-Lun So et al.   CANCER AND METASTASIS REVIEWS

Inhibition of eIF2α Dephosphorylation Maximizes Bortezomib Efficiency and Eliminates Quiescent Multiple Myeloma Cells Surviving Proteasome Inhibitor Therapy

(2009) Denis M. Schewe et al.   CANCER RESEARCH

Preventing oxidative stress: a new role for XBP1

(2009) Y Liu et al.   CELL DEATH AND DIFFERENTIATION

pXBP1(U), a Negative Regulator of the Unfolded Protein Response Activator pXBP1(S), Targets ATF6 but not ATF4 in Proteasome-mediated Degradation

(2009) Hiderou Yoshida et al.   CELL STRUCTURE AND FUNCTION

SAR Study of a Novel Triene-ansamycin Group Compound, Quinotrierixin and Related Compounds, as Inhibitors of ER Stress-induced XBP1 Activation

(2009) Tatsuro Kawamura et al.   JOURNAL OF ANTIBIOTICS

The anti-apoptotic role of the unfolded protein response in Bcr-Abl-positive leukemia cells

(2009) Atsuko Tanimura et al.   LEUKEMIA RESEARCH

IL-1β caused pancreatic β-cells apoptosis is mediated in part by endoplasmic reticulum stress via the induction of endoplasmic reticulum Ca2+ release through the c-Jun N-terminal kinase pathway

(2009) Q. Wang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Tunicamycin suppresses cisplatin-induced HepG2 cell apoptosis via enhancing p53 protein nuclear export

(2009) Li-Juan Zhang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

BAX Inhibitor-1 Is a Negative Regulator of the ER Stress Sensor IRE1α

(2009) Fernanda Lisbona et al.   MOLECULAR CELL

Identification of E2F1 as a positive transcriptional regulator for δ-catenin

(2008) Kwonseop Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A cell-penetrating peptidic GRP78 ligand for tumor cell-specific prodrug therapy

(2008) Yoshiyuki Yoneda et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Endoplasmic reticulum stress is a target for therapy in Waldenstrom macroglobulinemia

(2008) X. Leleu et al.   BLOOD

Down-regulation of GRP78 is associated with the sensitivity of chemotherapy to VP-16 in small cell lung cancer NCI-H446 cells

(2008) Yingyan Wang et al.   BMC CANCER

Expression and clinical significance of Glucose Regulated Proteins GRP78 (BiP) and GRP94 (GP96) in human adenocarcinomas of the esophagus

(2008) Rupert Langer et al.   BMC CANCER

Cigarette smoke induces endoplasmic reticulum stress and the unfolded protein response in normal and malignant human lung cells

(2008) Ellen Jorgensen et al.   BMC CANCER

Inhibition of MEK blocks GRP78 up-regulation and enhances apoptosis induced by ER stress in gastric cancer cells

(2008) Lin Jie Zhang et al.   CANCER LETTERS

Aggravated Endoplasmic Reticulum Stress as a Basis for Enhanced Glioblastoma Cell Killing by Bortezomib in Combination with Celecoxib or Its Non-Coxib Analogue, 2,5-Dimethyl-Celecoxib

(2008) A. Kardosh et al.   CANCER RESEARCH

Critical Role of the Stress Chaperone GRP78/BiP in Tumor Proliferation, Survival, and Tumor Angiogenesis in Transgene-Induced Mammary Tumor Development

(2008) D. Dong et al.   CANCER RESEARCH

Up-regulation of Mcl-1 Is Critical for Survival of Human Melanoma Cells upon Endoplasmic Reticulum Stress

(2008) C. C. Jiang et al.   CANCER RESEARCH

NVP-AUY922: A Novel Heat Shock Protein 90 Inhibitor Active against Xenograft Tumor Growth, Angiogenesis, and Metastasis

(2008) S. A. Eccles et al.   CANCER RESEARCH

Preferential Cytotoxicity of Bortezomib toward Hypoxic Tumor Cells via Overactivation of Endoplasmic Reticulum Stress Pathways

(2008) D. R. Fels et al.   CANCER RESEARCH

Insulin-like growth factor-I protects cells from ER stress-induced apoptosis via enhancement of the adaptive capacity of endoplasmic reticulum

(2008) R Novosyadlyy et al.   CELL DEATH AND DIFFERENTIATION

The unfolded protein response regulator GRP78/BiP is required for endoplasmic reticulum integrity and stress-induced autophagy in mammalian cells

(2008) J Li et al.   CELL DEATH AND DIFFERENTIATION

Upregulation of DR5 by proteasome inhibitors potently sensitizes glioma cells to TRAIL-induced apoptosis

(2008) Holger Hetschko et al.   FEBS Journal

Redox-based regulation of signal transduction: Principles, pitfalls, and promises

(2008) Yvonne M.W. Janssen-Heininger et al.   FREE RADICAL BIOLOGY AND MEDICINE

Overexpression of GRP78 and GRP94 are markers for aggressive behavior and poor prognosis in gastric carcinomas

(2008) Hua-chuan Zheng et al.   HUMAN PATHOLOGY

Alteration of cell-cycle regulation in epithelial ovarian cancer

(2008) E.J. NAM et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Protective Role of Hsp27 Protein Against Gamma Radiation–Induced Apoptosis and Radiosensitization Effects of Hsp27 Gene Silencing in Different Human Tumor Cells

(2008) Marie-Thérèse Aloy et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Nicotine Suppresses Tunicamycin-Induced, But Not Thapsigargin-Induced, Expression of GRP78 during ER Stress-Mediated Apoptosis in PC12 Cells

(2008) H. Sasaya et al.   JOURNAL OF BIOCHEMISTRY

Chemical Biology Investigation of Cell Death Pathways Activated by Endoplasmic Reticulum Stress Reveals Cytoprotective Modulators of ASK1

(2008) InKi Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcriptional Repression of the Prosurvival Endoplasmic Reticulum Chaperone GRP78/BIP by E2F1

(2008) Tomáš Racek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A new tumor-specific variant of GRP78 as target for antibody-based therapy

(2008) Nicole Rauschert et al.   LABORATORY INVESTIGATION

The Oncoprotein SS18-SSX1 Promotes p53 Ubiquitination and Degradation by Enhancing HDM2 Stability

(2008) P. D'Arcy et al.   MOLECULAR CANCER RESEARCH

Glucose-regulated protein 78 regulates multiple malignant phenotypes in head and neck cancer and may serve as a molecular target of therapeutic intervention

(2008) C.-C. Chiu et al.   MOLECULAR CANCER THERAPEUTICS

Loss of the Tuberous Sclerosis Complex Tumor Suppressors Triggers the Unfolded Protein Response to Regulate Insulin Signaling and Apoptosis

(2008) Umut Ozcan et al.   MOLECULAR CELL

Elucidation of susceptible factors to endoplasmic reticulum stress-mediated anticancer activity in human hepatocellular carcinoma

(2008) Po-Cheng Chiang et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

GRP78 is overexpressed in glioblastomas and regulates glioma cell growth and apoptosis

(2008) Hae Kyung Lee et al.   NEURO-ONCOLOGY

PERK-dependent regulation of IAP translation during ER stress

(2008) R B Hamanaka et al.   ONCOGENE

Unfolded protein response and cell death after depletion of brefeldin A-inhibited guanine nucleotide-exchange protein GBF1

(2008) C. Citterio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of Nrf2 by arsenite and monomethylarsonous acid is independent of Keap1-C151: enhanced Keap1–Cul3 interaction

(2008) Xiao-Jun Wang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Endoplasmic Reticulum Stress and Unfolded Protein Response in Atm-Deficient Thymocytes and Thymic Lymphoma Cells Are Attributable to Oxidative Stress

(2008) Mingshan Yan et al.   NEOPLASIA

A kinase inhibitor activates the IRE1α RNase to confer cytoprotection against ER stress

(2007) Dan Han et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Insulin induces chaperone and CHOP gene expressions in adipocytes

(2007) Yugo Miyata et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

HSP105 interacts with GRP78 and GSK3 and promotes ER stress-induced caspase-3 activation

(2007) Gordon P. Meares et al.   CELLULAR SIGNALLING

Endoplasmic reticulum stress induced by aqueous extracts of cigarette smoke in 3T3 cells activates the unfolded-protein-response-dependent PERK pathway of cell survival

(2007) Arnd Hengstermann et al.   FREE RADICAL BIOLOGY AND MEDICINE

Gadd45a Activation Protects Melanoma Cells from Ultraviolet B-Induced Apoptosis

(2007) Caroline Fayolle et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Induction of Apoptosis by Vinblastine via c-Jun Autoamplification and p53-Independent Down-Regulation of p21WAF1/CIP1

(2007) S. N. Kolomeichuk et al.   MOLECULAR PHARMACOLOGY

Efficient C2 functionalisation of 2H-2-imidazolines

(2007) Robin S. Bon et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Activation of Nrf2-mediated oxidative stress response in macrophages by hypochlorous acid

(2007) Jingbo Pi et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY