Screening TRPV1 antagonists for the treatment of pain: lessons learned over a decade

Capsaicin (TRPV1 Agonist) Therapy for Pain Relief

(2009) Helena Knotkova et al.   CLINICAL JOURNAL OF PAIN

Spinal interleukin-1β in a mouse model of arthritis and joint pain

(2008) Paolo M. Fiorentino et al.   ARTHRITIS AND RHEUMATISM

Aminoquinazolines as TRPV1 antagonists: Modulation of drug-like properties through the exploration of 2-position substitution

(2008) Charles A. Blum et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Pirt, a Phosphoinositide-Binding Protein, Functions as a Regulatory Subunit of TRPV1

(2008) Andrew Y. Kim et al.   CELL

Neurokinin 2 receptor-mediated activation of protein kinase C modulates capsaicin responses in DRG neurons from adult rats

(2008) Adrian Sculptoreanu et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Advances in the design and therapeutic use of capsaicin receptor TRPV1 agonists and antagonists

(2008) Laxmikant A Gharat et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Novel Gating and Sensitizing Mechanism of Capsaicin Receptor (TRPV1)

(2008) Toshio Ohta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Design and Synthesis of Peripherally Restricted Transient Receptor Potential Vanilloid 1 (TRPV1) Antagonists

(2008) Nuria Tamayo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Protein Kinase A Anchoring via AKAP150 Is Essential for TRPV1 Modulation by Forskolin and Prostaglandin E2 in Mouse Sensory Neurons

(2008) K. Schnizler et al.   JOURNAL OF NEUROSCIENCE

Endogenous Tumor Necrosis Factor   (TNF ) Requires TNF Receptor Type 2 to Generate Heat Hyperalgesia in a Mouse Cancer Model

(2008) C. E. Constantin et al.   JOURNAL OF NEUROSCIENCE

Studies on Somnolence in the Daytime Caused by Drugs Used for Neuropathic Pain

(2008) Yasuhiro Takeda et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Antihyperalgesic Effects of (R,E)-N-(2-Hydroxy-2,3-dihydro-1H-inden-4-yl)-3-(2-(piperidin-1-yl)-4-(trifluoromethyl)phenyl)-acrylamide (AMG8562), a Novel Transient Receptor Potential Vanilloid Type 1 Modulator That Does Not Cause Hyperthermia in Rats

(2008) S. G. Lehto et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

(R)-(5-tert-Butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)-urea (ABT-102) Blocks Polymodal Activation of Transient Receptor Potential Vanilloid 1 Receptors in Vitro and Heat-Evoked Firing of Spinal Dorsal Horn Neurons in Vivo

(2008) C. S. Surowy et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Proinflammatory Mediators Modulate the Heat-Activated Ion Channel TRPV1 via the Scaffolding Protein AKAP79/150

(2008) Xuming Zhang et al.   NEURON

Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans

(2008) Narender R. Gavva et al.   PAIN

Genetic mutations that prevent pain: implications for future pain medication

(2008) Bruno Oertel et al.   PHARMACOGENOMICS

Structure of TRPV1 channel revealed by electron cryomicroscopy

(2008) V. Y. Moiseenkova-Bell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA